Results 31 to 40 of about 6,092 (196)

First Succinylome Profiling of Vibrio alginolyticus Reveals Key Role of Lysine Succinylation in Cellular Metabolism and Virulence [PDF]

, 2021
Recent studies have shown that a key strategy of many pathogens is to use post-translational modification (PTMs) to modulate host factors critical for infection.
Li, Wanxin, Ramanathan, Srinivasan, Lin, Xiangmin, Pang, Huanying, Chen, Ying, Hoare, Rowena, Zheng, Hongwei, Monaghan, Sean J, Zeng, Fuyuan, Jian, Jichang   +9 more
core   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

iSuc-ChiDT: a computational method for identifying succinylation sites using statistical difference table encoding and the chi-square decision table classifier

BioData Mining, 2022
Background Lysine succinylation is a type of protein post-translational modification which is widely involved in cell differentiation, cell metabolism and other important physiological activities.
Ying Zeng, Yuan Chen, Zheming Yuan
doaj   +1 more source

Succinylation Regulators Promote Clear Cell Renal Cell Carcinoma by Immune Regulation and RNA N6-Methyladenosine Methylation

Frontiers in Cell and Developmental Biology, 2021
Succinylation is a newly discovered and multienzyme-regulated post-translational modification (PTM) that is associated with the initiation and progression of cancer. Currently, no systematic analyses on the role of succinylation regulators in tumors have
Wenqing Lu, Wenqing Lu, Wenqing Lu, Xiaofang Che, Xiaofang Che, Xiaofang Che, Xiujuan Qu, Xiujuan Qu, Xiujuan Qu, Chunlei Zheng, Chunlei Zheng, Chunlei Zheng, Xianghong Yang, Bowen Bao, Bowen Bao, Bowen Bao, Zhi Li, Zhi Li, Zhi Li, Duo Wang, Duo Wang, Duo Wang, Yue Jin, Yue Jin, Yue Jin, Yizhe Wang, Jiawen Xiao, Jianfei Qi, Yunpeng Liu, Yunpeng Liu, Yunpeng Liu   +30 more
doaj   +1 more source

Succinylation of Pepsinogen

Journal of Biological Chemistry, 1967
Succinic anhydride reacts with pepsinogen to form succinylpepsinogen in which the 10 e-amino groups of the lysine residues are succinylated. In addition reaction occurs with 16 tyrosine residues and 10 to 13 hydroxyamino acid residues of the protein. In contrast to the O-succinyltyrosines of succinylpepsinogen which are spontaneously decomposed in 3 to
A D, Gounaris, G E, Perlmann
openaire   +2 more sources

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

Cell Discovery, 2023
Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function.
Jialun Li, Lu Lu, Lingling Liu, Xuelian Ren, Jiwei Chen, Xingzhi Yin, Yanhui Xiao, Jiwen Li, Gang Wei, He Huang, Wei Wei, Jiemin Wong   +11 more
doaj   +1 more source

A review of the mechanism of succinylation in cancer

Medicine, 2022
Lysine succinylation is a novel, broad-spectrum, dynamic, non-enzymatic protein post-translational modification (PTM). Succinylation is essential for the regulation of protein function and control of various signaling and regulatory pathways. It is involved in several life activities, including glucose metabolism, amino acid metabolism, fatty acid ...
Keer Lu, Dongwei Han
openaire   +2 more sources

The Mystery of Extramitochondrial Proteins Lysine Succinylation

, 2021
Lysine succinylation is a post-translational modification which alters protein function in both physiological and pathological processes. Mindful that it requires succinyl-CoA, a metabolite formed within the mitochondrial matrix that cannot permeate the ...
Christos Chinopoulos
core   +1 more source

DeepSuccinylSite: a deep learning based approach for protein succinylation site prediction

BMC Bioinformatics, 2020
Background Protein succinylation has recently emerged as an important and common post-translation modification (PTM) that occurs on lysine residues. Succinylation is notable both in its size (e.g., at 100 Da, it is one of the larger chemical PTMs) and in
Niraj Thapa, Meenal Chaudhari, Sean McManus, Kaushik Roy, Robert H. Newman, Hiroto Saigo, Dukka B. KC   +6 more
doaj   +1 more source

Succinyl Phosphate and the Succinyl Coenzyme A Synthetase Reaction

Journal of Biological Chemistry, 1969
Trilithium succinyl phosphate of a high degree of purity has been synthesized chemically. It is active in the synthesis of ATP from ADP in a reaction catalyzed by succinyl coenzyme A synthetase from Escherichia coli (succinate: CoA ligase (ADP); EC 6.2.1.5).
J G, Hildebrand, L B, Spector
openaire   +2 more sources