Results 11 to 20 of about 6,092 (196)

Dysregulation of protein succinylation and disease development [PDF]

Frontiers in Molecular Biosciences
As a novel post-translational modification of proteins, succinylation is widely present in both prokaryotes and eukaryotes. By regulating protein translocation and activity, particularly involved in regulation of gene expression, succinylation actively ...
Xiaoli Hou, Lijuan Zhu, Haiying Xu, Jie Shi, Shaoping Ji, Shaoping Ji   +5 more
exaly   +4 more sources

Succinylation: A Functional Nexus Between Metabolic Reprogramming and Epigenetic Modifications in Cancer [PDF]

Molecules
Metabolic reprogramming and epigenetic remodeling are critical features of tumorigenesis. The process of metabolic reprogramming causes metabolites like Succinyl-CoA to accumulate.
Dan Liu, Runtian Li, Mingzhu Li, Fang Xu, Ying Liang, Yang Sun   +5 more
doaj   +3 more sources

Large-Scale Assessment of Bioinformatics Tools for Lysine Succinylation Sites

Cells, 2019
Lysine succinylation is a form of posttranslational modification of the proteins that play an essential functional role in every aspect of cell metabolism in both prokaryotes and eukaryotes.
Mst Shamima Khatun, Hiroyuki Kurata, Md Mehedi Hasan   +2 more
exaly   +4 more sources

Succinylation Improves the Thermal Stability of Egg White Proteins

Molecules, 2019
Succinylation can improve the thermal stability of various proteins. In this study, succinylated egg white protein (SEWP) samples with different succinylation degrees were prepared by adding various succinic anhydride additives to egg white protein (EWP).
Dabo He, Ying Lv, Qigen Tong
doaj   +2 more sources

Global analysis of protein lysine succinylation profiles in common wheat

BMC Genomics, 2017
Background Protein lysine succinylation is an important post-translational modification and plays a critical regulatory role in almost every aspects of cell metabolism in both eukaryotes and prokaryotes.
Yumei Zhang, Guangyuan Wang, Limin Song, Ping Mu, Shu Wang, Wenxing Liang, Qi Lin   +6 more
doaj   +2 more sources

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation [PDF]

Cell Reports, 2013
Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution.
Brian T. Weinert, Christian Schölz, Sebastian A. Wagner, Vytautas Iesmantavicius, Dan Su, Jeremy A. Daniel, Chunaram Choudhary   +6 more
doaj   +2 more sources

GPSuc: Global Prediction of Generic and Species-specific Succinylation Sites by aggregating multiple sequence features. [PDF]

PLoS ONE, 2018
Lysine succinylation is one of the dominant post-translational modification of the protein that contributes to many biological processes including cell cycle, growth and signal transduction pathways.
Md Mehedi Hasan, Hiroyuki Kurata
doaj   +2 more sources

Succinylation proteomic analysis identified differentially expressed succinylation sites affecting porcine muscle fiber type function

Food Chemistry: X, 2023
Muscle fiber type is a major factor in pork meat quality, however, the role of post-translational protein modifications, especially succinylation, in the regulation of muscle fiber type is not fully understood.
Xiaofan Tan, Kaiqing Liu, Yu He, Zhiwei Yan, Jing Chen, Ruixue Zhao, Xin Sui, Junpeng Zhang, David M. Irwin, Shuyi Zhang, Bojiang Li   +10 more
doaj   +2 more sources

Proteome-Wide Identification of Lysine Succinylation in the Proteins of Tomato (Solanum lycopersicum). [PDF]

PLoS ONE, 2016
Post-translational modification of proteins through lysine succinylation plays important regulatory roles in living cells. Lysine succinylation was recently identified as a novel post-translational modification in Escherichia coli, yeast, Toxoplasma ...
Weibo Jin, Fangli Wu
doaj   +2 more sources

Extensive comparison of protein sequence-based bioinformatics applications for predicting lysine succinylation sites: a comparative review

Biotechnology & Biotechnological Equipment
Lysine succinylation is a post-translational modification that occurs when a succinyl group bonds with a lysine residue and changes the polarity of lysine from positive to negative, causing significant changes in the structure and functioning of proteins.
Hussam Alsharif
doaj   +2 more sources