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Synthesis, Pharmacokinetic Characterization and Antioxidant Capacity of Carotenoid Succinates and Their Melatonin Conjugates [PDF]
Molecules, 2022 Carotenoid succinates were synthesized from hydroxy carotenoids and were coupled to a commercially available derivative of melatonin via amide bond for producing more powerful anti-oxidants and yet new hybrid lipophilic bifunctional molecules with ...
József Deli +2 more
exaly +4 more sources
Tetrahedron Chem, 2022 Succinates play a vital role in industry, pharmaceutics, beverage, and cosmetics. A regio- and stereoselective alkoxycarbonylation of unsymmetrical internal alkynes with alcohols or phenols toward α, β-unsaturated succinates enabled by palladium ...
Xiao-Feng Wu +2 more
exaly +3 more sources
Synthesis, antioxidant capacity and aggregation of carotenoid-curcumin conjugates and hybrids. [PDF]
PLoS ONEBoth curcumin and carotenoids are good antioxidants and curcumin has a pleiotropic effect additionally. To combine the beneficial properties carotenoid succinates were coupled to curcumin via ester bond.
Santiago Jijón +8 more
doaj +2 more sources
Polymorphism and Multi-Component Crystal Formation of GABA and Gabapentin [PDF]
Pharmaceutics, 2023 This study exploits the polymorphism and multi-component crystal formation of γ-amino butanoic acid (GABA) and its pharmaceutically active derivative, gabapentin.
Daniel Komisarek +5 more
doaj +2 more sources
Upcycling poly(succinates) with amines to N-substituted succinimides over succinimide anion-based ionic liquids [PDF]
Nature CommunicationsThe chemical transformation of waste polymers into value-added chemicals is of significance for circular economy and sustainable development. Herein, we report upcycling poly(succinates) (PSS) with amines into N-substituted succinimides over succinimide ...
Fengtian Wu +12 more
doaj +2 more sources
Gemigliptin Alleviates Succinate-Induced Hepatic Stellate Cell Activation by Ameliorating Mitochondrial Dysfunction [PDF]
Endocrinology and Metabolism, 2022 Background Dipeptidyl peptidase-4 inhibitors (DPP-4Is) are used clinically as oral antidiabetic agents. Although DPP-4Is are known to ameliorate liver fibrosis, the protective mechanism of DPP-4Is in liver fibrosis remains obscure.
Giang Nguyen +4 more
doaj +1 more source
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations [PDF]
Endocrinology and Metabolism, 2020 Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory ...
Yuqi Guo +3 more
doaj +1 more source
The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19
Антибиотики и Химиотерапия, 2021 The aim of the work was the search for materials from experimental and clinical studies reflecting the pathogenetic role of the possible use of succinates for the correction of hypoxia in COVID-19. Materials and methods.
Yu. Р. Orlov +2 more
doaj +1 more source
Mass Spectrometry Reviews, 2013 AbstractThe post‐translational modifications (PTMs) of cysteine residues include oxidation, S‐glutathionylation, S‐nitrosylation, and succination, all of which modify protein function or turnover in response to a changing intracellular redox environment.
Merkley, Eric D. +4 more
openaire +3 more sources
Антибиотики и Химиотерапия, 2023 Liberal oxygen therapy for COVID-19 causes hyperoxemia in most patients and reduces their survival rate. Even moderate hyperoxemia reduces oxygen delivery, and high levels of oxygen in central venous blood increase mortality in COVID-19 patients.
N. V. Govorova +4 more
doaj +1 more source