Results 1 to 10 of about 67,725 (262)

An analysis of succinate dehydrogenase B in pleural mesothelioma [PDF]

Discover Oncology
Aim To investigate the expression of succinate dehydrogenase B and its potential as a therapeutic target in pleural mesothelioma (PM). Methods The expression of succinate dehydrogenase B was examined in cell lines using PCR.
Cormac J. Jennings, Stefan J. Marciniak, Giulia Pinton, Doris M. Rassl, Laura Moro, Kenneth J. O’Byrne, Robert C. Rintoul, Stephen P. Finn, Luciano Mutti, Warren Thomas, Steven G. Gray   +10 more
doaj   +2 more sources

Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis

Redox Biology, 2021
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically compromising lung function and death. However, very little is known about
Yu Huang, Aihua Zhang, Ziyuan Zhou
exaly   +3 more sources

Imaging findings of succinate dehydrogenase‐deficient renal cell carcinoma [PDF]

Clinical Case Reports, 2023
Key Clinical Message A 50‐year‐old man with a mass located in the left kidney was described by multimodal images, including ultrasonography, computed tomography, and magnetic resonance imaging.
Wenqin Liu, Guiwu Chen, Jiaxin Meng, Xiaomin Liao, Yuhuan Xie   +4 more
doaj   +2 more sources

Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation [PDF]

Nature Communications
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on ...
Yifan Chen, Miao Xian, Wenwen Ying, Jiayi Liu, Shaowei Bing, Xiaomin Wang, Jiayi Yu, Xiaojun Xu, Senfeng Xiang, Xuejing Shao, Ji Cao, Qiaojun He, Bo Yang, Meidan Ying   +13 more
doaj   +2 more sources

Succinate and succinate dehydrogenase as a «foothold» in the Krebs cycle in critical conditions

Антибиотики и Химиотерапия, 2023
Purpose. Search and presentation of data from experimental and clinical studies reflecting the central role of succinate and succinate dehydrogenase in the regulation of adaptation mechanisms in critical conditions. Material and methods.
Yu. P. Orlov, A. V. Butrov, S. V. Sviridov, V. V. Afanasiev, A. N. Kondratiev, L. M. Tsentsiper, N. V. Govorova, A. I. Kondratiev, G. A. Baytugaeva, E. N. Kakulya   +9 more
doaj   +1 more source

Succinate dehydrogenase‐deficient malignant paraganglioma complicated by succinate dehydrogenase‐deficient renal cell carcinoma

IJU Case Reports, 2022
Introduction SDH Gene mutation is known to be a common cause of pheochromocytoma/paraganglioma and renal cell carcinoma. Here, we report a case of succinate dehydrogenase B‐deficient paraganglioma, which has a high risk of metastasis and recurrence ...
Yoshitomo Yamaguchi, Minato Yokoyama, Akira Takemoto, Yuki Nakamura, Shohei Fukuda, Sho Uehara, Hajime Tanaka, Soichiro Yoshida, Yoh Matsuoka, Yasuhisa Fujii   +9 more
doaj   +1 more source

Succinic Dehydrogenase in Protozoa [PDF]

Nature, 1947
THERE is, as yet, relatively little information about the occurrence of individual enzymes in Protozoa. We have been successful in demonstrating the presence of a succinic dehydrogenase in homogenates of Paramecium caudatum. This has been done using a modified Cartesian diver respirometer of macro dimensions (40–60 µ1. total volume).
B A, HUMPHREY, G F, HUMPHREY
openaire   +2 more sources

Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports

Journal of Medical Case Reports, 2021
Background Pheochromocytoma and paraganglioma caused by succinate dehydrogenase gene mutations is called hereditary pheochromocytoma/paraganglioma syndrome.
Rei Hirose, Yuya Tsurutani, Chiho Sugisawa, Kosuke Inoue, Sachiko Suematsu, Maki Nagata, Naoki Hasegawa, Yukio Kakuta, Masato Yonamine, Kazuhiro Takekoshi, Noriko Kimura, Jun Saito, Tetsuo Nishikawa   +12 more
doaj   +1 more source

TCA cycle tailoring facilitates optimal growth of proton-pumping NADH dehydrogenase-dependent Escherichia coli

Microbiology Spectrum, 2023
The bacterial lifestyle is plastic, requiring transcriptional, translational, and metabolic tailoring for survival. These dynamic cellular processes are energy intensive; therefore, flexible energetics is requisite for adaptive plasticity.
Nikita Goel, Stuti Srivastav, Arjun Patel, Akshay Shirsath, Tushar Ranjan Panda, Malay Patra, Adam M. Feist, Amitesh Anand   +7 more
doaj   +1 more source

The Synthesis of Succinate‐Dehydrogenase Riboflavin [PDF]

Angewandte Chemie International Edition in English, 1970
Singer and Kearney"], in their early studies, recognized that the flavocoenzyme of mitochondria1 succinate dehydrogenase ("SD-flavin") [**I was a derivative of flavin-adenine-dinucleotide which was covalently bound to the protein. In cooperation with Dr. Singer's team [***I, we have attempted to elucidate the structure of this coenzyme.
Ghisla, Sandro, Hartmann, Ursula, Hemmerich, Peter   +2 more
openaire   +3 more sources