Results 41 to 50 of about 233,572 (253)

Isolation of succinate dehydrogenase from Desulfobulbus elongatus, a propionate oxidizing, sulfate reducing bacterium [PDF]

, 1987
Succinate dehydrogenase was purified from the particulate fraction of Desulfobulbus. The enzyme catalysed both fumarate reduction and succinate oxidation but the rate of fumarate reduction was 8-times less than that of succinate oxidation.
G. Albagnac, LeGall, J., E. Samain, D.S. Patil, J. LeGall, Albagnac, G., Samain, E., Patil, D.S., DerVartanian, D.V., D.V. DerVartanian   +9 more
core   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Succinate dehydrogenase. II. The effect of phospholipases on particulate and soluble succinate dehydrogenase.

, 1969
The activity of beef-heart succinate dehyrogenase (succinate:(acceptor) oxidoreductase, EC 1.3.99.1) in particulate preparations is not affected by phospholipase A (phosphatide acyl-hydrolase, EC 3.1.1.4) but is inhibited by the action of phospholipase C
M. A. Giovenco, P. Cerletti, M. G. Giordano, CAIAFA, Paola   +3 more
core   +1 more source

Immediate-Type Hypersensitivity to Succinylated Corticosteroids [PDF]

, 2010
Background: Despite their frequent use, systemic corticosteroids have rarely elicited immediate-type reactions. Objective: We report two male patients, aged 26 and 70 years, respectively, with severe immediate-type hypersensitivity secondary to the ...
Raewer, Helen-Caroline, Helen-Caroline Räwer, Wolfgang Sieber, Sieber, Wolfgang, Walker, Annett Isabel, Annett Isabel Walker, Przybilla, Bernhard, Bernhard Przybilla   +7 more
core   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle

Nature Communications
A prevalent side-reaction of succinate dehydrogenase oxidizes malate to enol-oxaloacetate (OAA), a metabolically inactive form of OAA that is a strong inhibitor of succinate dehydrogenase. We purified from cow heart mitochondria an enzyme (OAT1) with OAA
Anthony J. Zmuda, Xiaojun Kang, Katie B. Wissbroecker, Katrina Freund Saxhaug, Kyle C. Costa, Adrian D. Hegeman, Thomas D. Niehaus   +6 more
doaj   +1 more source

Effects of ultrasound waves on rat liver mitochondria [PDF]

BIO Web of Conferences
Succinate dehydrogenase has a wide range of properties in plant and animal cells and is distributed throughout the inner membrane of mitochondria, therefore it is the enzyme without which energy metabolism cannot occur.
Babakhanova Dilnoza, Mirkhamidova Parida, Alimova Rano, Shakhmurova Gulnara, Mukhamedov Gafurzhon   +4 more
doaj   +1 more source

SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GIST

Hematology, Transfusion and Cell Therapy, 2022
Case report Gastrointestinal stromal tumors (GISTs) occur exceedingly rare in children and adolescents. Eighty five percent of pediatric GISTs and 15 % of adult GISTs lack oncogenic mutations in KIT and PDGFRA.
Melek Yaman Ortakoylu, Sonay Incesoy Ozdemir, Handan Dincaslan, Nurdan Tacyildiz, Isınsu Kuzu, Emel Cabi Unal   +5 more
doaj   +1 more source

SDHC (succinate dehydrogenase complex II, subunit C, integral membrane protein) [PDF]

, 2002
Review on SDHC (succinate dehydrogenase complex II, subunit C, integral membrane protein), with data on DNA, on the protein encoded, and where the gene is ...
AP Gimenez-Roqueplo, Gimenez-Roqueplo, AP   +1 more
core   +1 more source