Results 31 to 40 of about 233,572 (253)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Biochemical and histochemical chenges in the activity of succinate dehydrogenase and ATP-ase in mitochondria of kidneys rats by acute intoxication

Journal of Education, Health and Sport, 2018
Оbject of the study was to evaluate activities of succinate dehydrogenase and ATP-ase in mitochondria of kidney under conditions of toxic influence of 2,4-dinitrophenol. The experiment was conducted on 60 male albino rats. Toxic damage was caused by 0.1%
M. V. Dikal, Ye. O. Ferenchuk, T. M. Bilous, M. I. Grytsiuk, T. G. Kopchuk   +4 more
doaj   +3 more sources

Regulation of succinate dehydrogenase and role of succinate in cancer

, 2020
Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme with the unique property to participate in both the citric acid cycle and the electron transport chain.
Liboi, Elio, Pacchiana, Raffaella, Dando, Ilaria, Donadelli, Massimo, Palmieri, Marta, Dalla Pozza, Elisa, Scupoli, Maria Teresa   +6 more
core   +1 more source

A novel mutation in the succinate dehydrogenase subunit D gene in siblings with the hereditary paraganglioma–pheochromocytoma syndrome

SAGE Open Medical Case Reports, 2014
Germline mutations in the succinate dehydrogenase complex subunit D gene are now known to be associated with hereditary paraganglioma–pheochromocytoma syndromes.
Chaithra Prasad, Gerard J Oakley, Linwah Yip, Christopher Coyne, Balasubramanya Rangaswamy, Sanjay B Dixit   +5 more
doaj   +1 more source

Imaging findings of succinate dehydrogenase‐deficient renal cell carcinoma

Clinical Case Reports, 2023
Key Clinical Message A 50‐year‐old man with a mass located in the left kidney was described by multimodal images, including ultrasonography, computed tomography, and magnetic resonance imaging.
Wenqin Liu, Guiwu Chen, Jiaxin Meng, Xiaomin Liao, Yuhuan Xie   +4 more
doaj   +1 more source

Succinate dehydrogenase inhibitor dimethyl malonate alleviates LPS/-galactosamine-induced acute hepatic damage in mice

Innate Immunity, 2019
In addition to its energy-supplying function, increasing evidence suggests that mitochondria also play crucial roles in the regulation of inflammation.
Yongqiang Yang, Ruyue Shao, Li Tang, Longjiang Li, Min Zhu, Jiayi Huang, Yi Shen, Li Zhang   +7 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Succinate detection in glomus jugulare paraganglioma on MRS as a marker for SDHB mutation

Otolaryngology Case Reports, 2020
Succinate dehydrogenase gene mutation (SDH) is known as a cause of familial paraganglioma, and the dysfunction of SDH leads to the accumulation of succinate in the cell.
Shotaro Naganawa, Aristides A. Capizzano, Yoshiaki Ota, John Kim, Ashok Srinivasan, Toshio Moritani   +5 more
doaj   +1 more source

Biochemical and mitochondrial membrane potential changes relating to betulinic acid-mediated anticancer activity in murine ascites Dalton's lymphoma

Phytomedicine Plus, 2022
Background: Betulinic acid, a naturally occurring pentacyclic triterpenoid is found in a variety of plants. A range of biological properties including anticancer activity has been reported for betulinic acid.
Anamika Bhaumik, Atanu Bhattacharjee, Surya Bali Prasad   +2 more
doaj   +1 more source

Succinate dehydrogenase. 3. Stability and interaction with phosphatides.

, 1970
The stability of soluble succinate dehydrogenase and the effect of phosphatides on dehydrogenase activity were studied. Phosphatides stabilize dehydrogenase preparations solubilized in the presence of succinate but do not affect the dehydrogenase ...
P. Cerletti, G. Testolin, M. G. Giordano, CAIAFA, Paola, P. Caiafa   +4 more
core   +1 more source