Results 11 to 20 of about 233,572 (253)

Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis. [PDF]

PLoS Pathogens, 2014
In chronic infection, Mycobacterium tuberculosis bacilli are thought to enter a metabolic program that provides sufficient energy for maintenance of the protonmotive force, but is insufficient to meet the demands of cellular growth.
Travis Hartman, Brian Weinrick, Catherine Vilchèze, Michael Berney, Joanne Tufariello, Gregory M Cook, William R Jacobs   +6 more
doaj   +2 more sources

Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics [PDF]

International Journal of Endocrinology, 2015
It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in
Yeng F. Her, L. James Maher
doaj   +2 more sources

Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad [PDF]

Biomedicines, 2022
Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism.
Paule Bénit, Judith Goncalves, Riyad El Khoury, Malgorzata Rak, Judith Favier, Anne-Paule Gimenez-Roqueplo, Pierre Rustin   +6 more
doaj   +2 more sources

Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor.

PLoS ONE, 2019
Mitochondrial disorders arise from defects in nuclear genes encoding enzymes of oxidative metabolism. Mutations of metabolic enzymes in somatic tissues can cause cancers due to oncometabolite accumulation. Paraganglioma and pheochromocytoma are examples,
Megan M Braun, Tamara Damjanac, Yuxia Zhang, Chuan Chen, Jinghua Hu, L James Maher   +5 more
doaj   +2 more sources

Modification-Selective Inhibition of Succinate Dehydrogenase a Enables Tumor-Restricted Mitochondrial Modulation. [PDF]

Adv Sci (Weinh)
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Xu K, Kong L, Ye K, Bao X, Liu H, Wang N, Deng Y, Wang W, Wei S, Zhou L.   +9 more
europepmc   +2 more sources

The aggressiveness of succinate dehydrogenase subunit B-deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide [PDF]

, 2023
Pheochromocytomas/paragangliomas (PPGLs) are neuroendocrine tumours, mostly resulting from mutations in predisposing genes. Mutations of succinate dehydrogenase (SDH) subunit B (SDHB) are associated with high probability of metastatic disease.
Daniele Guasti, Rachele Garella, Maggi, Mario, Rapizzi, Elena, Bani, Daniele, Neuzil, Jiri, Martinelli, Serena, Amore, Francesca, Mario Maggi, Elena Rapizzi, Canu, Letizia, Francesca Amore, Letizia Canu, Alice Santi, Serena Martinelli, Santi, Alice, Roberta Squecco, Garella, Rachele, Guasti, Daniele, Jiri Neuzil, Daniele Bani, Squecco, Roberta   +21 more
core   +1 more source

Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas

, 2021
Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative.
Hadrava Vanova, Katerina, Richter, Susan, Merino, Maria J, Bechmann, Nicole, Neuzil, Jiri, Wesley, Robert, Martinez-Montes, Angel M, Calsina, Bruna, Matlac, Dieter M, Abunimer, Luma, Ghayee, Hans K, Folberth, Julica, Ge, Guang-Bo, Aherrahrou, Redouane, Dona, Margo, et al.   +15 more
core   +1 more source

Succinate dehydrogenase (SDH)-deficient renal carcinoma:a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients [PDF]

, 2014
Succinate dehydrogenase (SDH)-deficient renal carcinoma has been accepted as a provisional entity in the 2013 International Society of Urological Pathology Vancouver Classification.
Sedivcová, Monika, Yu, Darryl, Papathomas, Thomas, Niemeijer, Nicolasine D., Przybycin, Christopher, Nicoll, Katherine D, Paik, Julie, Miettinen, Markku, Yong, Jim L., Kedziora, Andrew, Andresen, Per Arne, Hes, Ondrej, Toon, Christopher W., Robinson, Bruce G, Corssmit, Eleonora P M, Michal, Michal, Chou, Angela, Hills, Kirsten, Nicoll, Katherine D., Clarkson, Adele, Clifton-bligh, Roderick J., Yong, Jim L, Maclean, Fiona, Yilmaz, Asli, Vlatkovic, Ljiljana, Niemeijer, Nicolasine D, Hartmann, Arndt, Sibony, Mathilde, Agaimy, Abbas, McKenney, Jesse K, Robinson, Bruce G., Van Leenders, Geert J.l.h., Chow, Chung W., Sioson, Loretta, Mckenney, Jesse K., Corssmit, Eleonora P.m., Tan, Puay Hoon, van Leenders, Geert J L H, Yakirevich, Evgeny, Trpkov, Kiril, Benn, Diana E., Gill, Anthony J., Chow, Chung W, Watson, Nicole, Fleming, Stewart, Magi-Galluzzi, Cristina, Clifton-Bligh, Roderick J   +46 more
core   +1 more source

Production, characterization and determination of the real catalytic properties of the putative "succinate dehydrogenase" from Wolinella succinogenes [PDF]

, 2009
Both the genomes of the epsilonproteobacteria Wolinella succinogenes and Campylobacter jejuni contain operons (sdhABE) that encode for so far uncharacterized enzyme complexes annotated as ‘non-classical’ succinate:quinone reductases (SQRs).
Juhnke, Hanno Dominik, Hiltscher, Heiko, Juhnke, H., Schwalbe, H., Hamid R. Nasiri, Lancaster, C. Roy D., Nasiri, Hamid R., Heiko Hiltscher, Schwalbe, Harald, Nasiri, H., Harald Schwalbe, Juhnke, Hanno D., C. Roy D. Lancaster, Nasiri, Hamid Reza, Lancaster, C., Hanno D. Juhnke, Hiltscher, H.   +16 more
core   +1 more source

Clinicoradiological manifestations of paraganglioma syndromes associated with succinyl dehydrogenase enzyme mutation. [PDF]

, 2011
BACKGROUND: Paragangliomas are rare tumours derived from the autonomic nervous system that have increasingly been recognised to have a genetic predisposition.
Hodgson, S, Brendan Barber, Khan, S, Bano, G, Mark Ingram, Ingram, M, Vlahos, I, Gul Bano, Barber, B, Shirley Hodgson, Ioannis Vlahos, Sameer Khan   +11 more
core   +2 more sources