Results 1 to 10 of about 193,960 (302)

Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad

Biomedicines, 2022
Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism.
Paule Bénit, Judith Goncalves, Riyad El Khoury, Malgorzata Rak, Judith Favier, Anne-Paule Gimenez-Roqueplo, Pierre Rustin   +6 more
doaj   +1 more source

Spectrometric analysis of the compatibility of succinic acid with iodinol and metronidazole in the animal wound-healing liposomal gel

Аграрная наука Евро-Северо-Востока, 2023
The expediency of including succinic acid (succinate) in wound healing gels has been studied and scientifically substantiated by infrared spectrometry. For this purpose, the interaction of antiseptic components of wound healing gels – metronidazole and ...
V. V. Mosyagin, A. G. Belyaev
doaj   +1 more source

Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis

Frontiers in Immunology, 2022
Inflammation is an important driver of atherosclerosis. Succinate is a new extracellular inflammatory alarm released by activated macrophages. Succinate is sensed by succinate receptor 1 (Sucnr1) and then transferred to effector cells.
Jingwen Xu, Yabing Zheng, Yaqing Zhao, Yujiao Zhang, Huilin Li, An Zhang, Xuehan Wang, Weizong Wang, Yinglong Hou, Jiangrong Wang   +9 more
doaj   +1 more source

NADES Compounds Identified in Hypoxis hemerocallidea Corms during Dormancy

Plants, 2022
Soaking Hypoxis hemerocallidea corms in distilled water improved the propagation and development of cormlets, suggesting the potential leaching-out of inhibitory chemical compounds.
Motiki M. Mofokeng, Gerhard Prinsloo, Hintsa T. Araya, Stephen O. Amoo, Christian P. du Plooy, Phatu W. Mashela   +5 more
doaj   +1 more source

Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle

Biomedicines, 2022
Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using
Wei-Chia Lee, Hong-Ren Yu, You-Lin Tain, Kay L.H. Wu, Yao-Chi Chuang, Julie Y.H. Chan   +5 more
doaj   +1 more source

Targeted Redox Regulation α-Ketoglutarate Dehydrogenase Complex for the Treatment of Human Diseases

Cells
α-ketoglutarate dehydrogenase complex (KGDHc) is a crucial enzyme in the tricarboxylic acid (TCA) cycle that intersects monosaccharides, amino acids, and fatty acid catabolism with oxidative phosphorylation (OxPhos). A key feature of KGDHc is its ability
Ryan J. Mailloux
doaj   +1 more source

Pseudomonas aeruginosa Consumption of Airway Metabolites Promotes Lung Infection

Pathogens, 2021
Prevailing dogma indicates that the lung of cystic fibrosis (CF) individuals is infected by multiple pathogens due to the abundant accumulation of mucus, which traps most of inhaled organisms.
Sebastián A. Riquelme, Alice Prince
doaj   +1 more source

Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase

Metabolites, 2021
Itaconate is a small molecule metabolite that is endogenously produced by cis-aconitate decarboxylase-1 (ACOD1) in mammalian cells and influences numerous cellular processes.
Thekla Cordes, Christian M. Metallo
doaj   +1 more source

Experimental substantiation of permeabilized hepatocytes model for investigation of mitochondria in situ respiration [PDF]

The Ukrainian Biochemical Journal, 2015
To verify experimentally the model of permeabilized hepatocytes, the degree of cell permeability was assessed using trypan blue and polarographycally determined cell respiration rate upon succinate (0.35 mM) and α-ketoglutarate (1 mM) oxidation ...
V. M. Merlavsky, B. O. Manko, O. V. Ikkert, V. V. Manko   +3 more
doaj   +1 more source

Visualization and Quantification of Genetically Adapted Microbial Cells During Preculture

Frontiers in Microbiology, 2021
As culture history is known to affect the length of the lag phase and microbial cell growth, precultures are often grown in the same medium as the main culture for physiological adaptation and to reduce a prolonged lag time in some microbial cells.
Hyun Ju Kim, Haeyoung Jeong, Sang Jun Lee   +2 more
doaj   +1 more source