Results 31 to 40 of about 162,568 (118)

Succinate Is a Natural Suppressor of Antiviral Immune Response by Targeting MAVS

Frontiers in Immunology, 2022
Succinate is at the crossroads of multiple metabolic pathways and plays a role in several immune responses acting as an inflammation signal. However, whether succinate regulates antiviral immune response remains unclear.
Yue Xiao, Xinyi Chen, Zhun Wang, Jiazheng Quan, Xibao Zhao, Haimei Tang, Han Wu, Qianqian Di, Zherui Wu, Weilin Chen   +9 more
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Flexible Thermal Sensitivity of Mitochondrial Oxygen Consumption and Substrate Oxidation in Flying Insect Species

Frontiers in Physiology, 2022
Mitochondria have been suggested to be paramount for temperature adaptation in insects. Considering the large range of environments colonized by this taxon, we hypothesized that species surviving large temperature changes would be those with the most ...
Hichem A. Menail, Hichem A. Menail, Simon B. Cormier, Simon B. Cormier, Mariem Ben Youssef, Lisa Bjerregaard Jørgensen, Jess L. Vickruck, Pier Morin, Luc H. Boudreau, Luc H. Boudreau, Nicolas Pichaud, Nicolas Pichaud   +11 more
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Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity

Gut Microbes
Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus; however, many patients respond poorly to this drug in clinical practice. The potential involvement of microbiota-mediated intestinal immunity and related signals in metformin ...
Ying Zhang, Aiting Wang, Wei Zhao, Jia’an Qin, Yu Zhang, Bing Liu, Chengcheng Yao, Jianglan Long, Mingxia Yuan, Dan Yan   +9 more
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Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish

Frontiers in Molecular Biosciences, 2021
Development of immunity-based strategy to manage bacterial infection is urgently needed in aquaculture due to the widespread of antibiotic-resistant bacteria.
Dai-xiao Yang, Dai-xiao Yang, Dai-xiao Yang, Hao Yang, Hao Yang, Hao Yang, Yun-chao Cao, Yun-chao Cao, Yun-chao Cao, Ming Jiang, Ming Jiang, Ming Jiang, Jun Zheng, Bo Peng, Bo Peng, Bo Peng   +15 more
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Efficacy of a postbiotic and its components in promoting colonic transit and alleviating chronic constipation in humans and mice

Cell Reports Medicine
Summary: This study evaluates the efficacy of the postbiotic Probio-Eco in alleviating constipation in humans and mice. A randomized, double-blind, placebo-controlled crossover trial involving 110 adults with chronic constipation (Rome IV criteria ...
Teng Ma, Yalin Li, Ni Yang, Huan Wang, Xuan Shi, Yanfang Liu, Hao Jin, Lai-Yu Kwok, Zhihong Sun, Heping Zhang   +9 more
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Succinate/NLRP3 inflammasome induces synovial fibroblast activation: therapeutical effects of clematichinenoside AR on arthritis

Frontiers in Immunology, 2016
Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the treatment of arthritis.
Yi Li, Jia-Yi Zheng, Jian-Qun Liu, Jie Yang, Yang Liu, Chen Wang, Xiao-Nan Ma, Bao-Lin Liu, Gui-Zhong Xin, Li-Fang Liu   +9 more
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Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat

Antioxidants, 2021
Reflex increases in breathing in response to acute hypoxia are dependent on activation of the carotid body (CB)—A specialised peripheral chemoreceptor.
Agnieszka Swiderska, Andrew M. Coney, Abdulaziz A. Alzahrani, Hayyaf S. Aldossary, Nikolaos Batis, Clare J. Ray, Prem Kumar, Andrew P. Holmes   +7 more
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Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Cell Reports, 2021
Summary: Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate receptor SUCNR1. In the present study, we characterize and compare effects and signaling pathways
Mette Trauelsen, Thomas K. Hiron, Da Lin, Jacob E. Petersen, Billy Breton, Anna Sofie Husted, Siv A. Hjorth, Asuka Inoue, Thomas M. Frimurer, Michel Bouvier, Chris A. O’Callaghan, Thue W. Schwartz   +11 more
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Crc Regulates Succinate-Mediated Repression of Mineral Phosphate Solubilization in Acinetobacter sp. SK2 by Modulating Membrane Glucose Dehydrogenase

Frontiers in Microbiology, 2021
The plant growth-promoting Acinetobacter sp. SK2 isolated from Vigna radiata rhizosphere was characterized for mineral phosphate solubilization (MPS).
Krishna Bharwad, Niharika Ghoghari, Shalini Rajkumar   +2 more
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Succinate Regulates Endothelial Mitochondrial Function and Barrier Integrity

Antioxidants
Endothelial dysfunction is a hallmark of several pathological conditions, including cancer, cardiovascular disease and inflammatory disorders. In these conditions, perturbed TCA cycle and subsequent succinate accumulation have been reported.
Reham Atallah, Juergen Gindlhuber, Wolfgang Platzer, Rishi Rajesh, Akos Heinemann   +4 more
doaj   +1 more source