Results 1 to 10 of about 1,568 (147)

Sensing succinate: SUCNR1 as a context-dependent metabolic and cellular signal integrator [PDF]

Frontiers in Molecular Biosciences
Succinate (SUC), a central intermediate in the mitochondrial tricarboxylic acid (TCA) cycle, functions not only as a metabolic substrate but also acts as the endogenous ligand for succinate receptor 1 (SUCNR1), a Gi- and Gq protein-coupled receptor.
Aenne-Dorothea Liebing, Claudia Stäubert   +1 more
doaj   +3 more sources

The Succinate Receptor SUCNR1 Resides at the Endoplasmic Reticulum and Relocates to the Plasma Membrane in Hypoxic Conditions

Cells, 2022
The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle metabolite succinate. GPCR signaling depends on the surrounding environment and intracellular localization through location bias.
Fernand Gobeil, Emmanuel Bajon, Vikrant K Bhosle   +2 more
exaly   +5 more sources

Association Between Succinate Receptor SUCNR1 Expression and Immune Infiltrates in Ovarian Cancer [PDF]

Frontiers in Molecular Biosciences, 2020
BackgroundThe activation of succinate receptor 1 (SUCNR1) by extracellular succinate has been found to regulate immune cell function. However, the clinical significance of SUCNR1 in ovarian cancer and its correlation with tumor-infiltrating lymphocytes ...
Yongbin Yang, Jiawen Zhang, Qingying Wang   +2 more
exaly   +5 more sources

SUCNR1 Mediates the Priming Step of the Inflammasome in Intestinal Epithelial Cells: Relevance in Ulcerative Colitis [PDF]

Biomedicines, 2022
Intestinal epithelial cells (IECs) constitute a defensive physical barrier in mucosal tissues and their disruption is involved in the etiopathogenesis of several inflammatory pathologies, such as Ulcerative Colitis (UC).
Juan Vicente Esplugues Mota, Sara Calatayud, Laura Gisbert-Ferrándiz   +2 more
exaly   +5 more sources

Hyperglycemia aggravates vitiligo through succinate/SUCNR1-mediated T cell activation [PDF]

The Journal of Clinical Investigation
Vitiligo is an autoimmune skin disease characterized by depigmentation, mainly due to CD8+ T cell–mediated destruction of melanocytes. Hyperglycemia exacerbates autoimmune responses and is associated with vitiligo; however, the underlying immunometabolic
Pan Kang, Yuqian Chang, Tingting Wang, Xiuli Yi, Yinghan Wang, Pengran Du, Jiaxi Chen, Baizhang Li, Shuli Li, Zhongjun Shao, Jianru Chen, Chunying Li   +11 more
doaj   +3 more sources

Integrative Drug-Target Causal Analysis, Single-Cell Sequencing and In-Vivo Validation for Dissecting Molecular Mechanisms Underlying Focal Epilepsy. [PDF]

CNS Neurosci Ther
Through Mendelian randomization analysis of the quantitative trait locus data, we identified that four drug targets, namely CASP1, FST, IL10RA, and SUCNR1, have significant genetic associations with the risk of focal epilepsy. This analysis provides preliminary genetic evidence for the causal mechanism by which these targets are involved in the onset ...
Sun H, Li X, Zhao W, Meng H, Zhang W.
europepmc   +2 more sources

Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression [PDF]

Nature Communications
Despite intriguing roles for the Succinate receptor (Sucnr1) in inflammation, few studies have explored its role in hematopoiesis. Here, we show that low SUCNR1 represents a marker for reduced overall and progression-free survival in acute myeloid ...
Vincent Cuminetti, Emeline Boet, Marcel Heugel, Joanna Konieczny, Aurora Bernal, Manuel J. Gomez, Franco Grimolizzi, Nuria Vilaplana-Lopera, Marc Ferré, Alicia Villatoro, Deo P. Pandey, Carlos Torroja, Hagar Taman, Ruth H. Paulssen, Thomas Vogl, Caroline A. Heckman, Anders Vik, Giovanna Giovinazzo, Nick van Gastel, Paloma García, Fátima Sánchez-Cabo, Jean-Emmanuel Sarry, Lorena Arranz   +22 more
doaj   +2 more sources

Acute Succinate Administration Increases Oxidative Phosphorylation and Skeletal Muscle Explosive Strength via SUCNR1

Frontiers in Veterinary Science, 2022
Endurance training and explosive strength training, with different contraction protein and energy metabolism adaptation in skeletal muscle, are both beneficial for physical function and quality of life.
Guli Xu, , Canjun Zhu
exaly   +3 more sources

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Cell Reports, 2021
Summary: Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate receptor SUCNR1. In the present study, we characterize and compare effects and signaling pathways
Anna Sofie Husted, Thue W Schwartz, Michel Bouvier   +2 more
exaly   +3 more sources

Gut microbiota-induced elevation of succinate exacerbates diabetic myocardial ischemia/reperfusion injury by promoting macrophage polarization [PDF]

Frontiers in Immunology
IntroductionPatients with diabetes exhibit increased susceptibility to myocardial ischemia/reperfusion (IR) injury. Emerging evidence highlights gut microbiota-derived microbial metabolites as critical modulators of the gut–heart axis.
Yang Wu, Juan Dou, Min Liu, Song Peng, Wenyuan Li   +4 more
doaj   +2 more sources