SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes. [PDF]
Diabetologia, 2017 Obesity induces macrophages to drive inflammation in adipose tissue, a crucial step towards the development of type 2 diabetes. The tricarboxylic acid (TCA) cycle intermediate succinate is released from cells under metabolic stress and has recently ...
van Diepen, Janna A. +3 more
core +12 more sources
A succinate/SUCNR1-brush cell defense program in the tracheal epithelium [PDF]
Science Advances, 2023 Repository file of dataset generated and/or analyzed during the study entitled 'A succinate/SUCNR1-brush cell defense program in the tracheal epithelium'.
Krupali Poharkar (15379292) +18 more
core +6 more sources
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity [PDF]
Nature Immunology, 2019 Succinate is a signaling metabolite sensed extracellularly by succinate receptor 1 (SUNCR1). The accumulation of succinate in macrophages is known to activate a pro-inflammatory program; however, the contribution of SUCNR1 to macrophage phenotype and ...
Ejarque, Miriam +18 more
core +8 more sources
Succinate-mediated metabolic alterations and signaling in RA: mechanisms and therapeutic implications [PDF]
Frontiers in ImmunologyRheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation. Recent studies have revealed that immune metabolites, particularly succinate, play a critical role in its pathogenesis.
Yi Fan +3 more
doaj +2 more sources
Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions
Aging, 2013 International audienceAge-related macular degeneration (AMD) is a prominent cause of blindness in the Western world. To date, its molecular pathogenesis as well as the sequence of events leading to retinal degeneration remain largely ill-defined.
Picard, Émilie +14 more
core +3 more sources
Protective succinate-SUCNR1 metabolic stress signaling gone bad
Cell Metabolism, 2021 The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al.
Winther, Sally +2 more
core +4 more sources
Microglial succinate receptor 1 (SUCNR1) sustains chronic CNS inflammation [PDF]
The rapidly evolving field of immunometabolism has shed new light on new fundamental properties of metabolites, which can regulate inflammation via ligand-receptor signalling modalities. Among these, succinate signalling via succinate receptor 1 (SUCNR1)
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Fueling bone loss: the immunometabolic reprogramming of the bone microenvironment in diabetic osteoporosis [PDF]
Frontiers in ImmunologyDiabetic osteoporosis (DOP) is a serious skeletal complication of type 2 diabetes mellitus (T2DM), characterized by deteriorated bone microarchitecture and elevated fracture risk independent of reduced bone mineral density.
Yunfang Wang +15 more
doaj +2 more sources
Bittersweet: how hyperglycemia exacerbates vitiligo progression through the succinate/SUCNR1 axis [PDF]
The Journal of Clinical InvestigationVitiligo is a depigmenting disease marked by progressive T cell–driven destruction of melanocytes in the skin, hair, and mucosa. While vitiligo is known to be a T cell–mediated autoimmune disease, its triggers have remained poorly understood and ...
Kaitlyn G. O’Donnell +1 more
doaj +2 more sources
Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis [PDF]
Communications BiologyAge-related cardiac fibrosis is a key driver of heart failure and hallmark of aging whose mechanisms remain incompletely understood. Here we show elevated succinate levels in aged mice and humans drive cardiac fibrosis by enhancing fibroblast activation ...
Ziwen Wang +17 more
doaj +2 more sources