Results 21 to 30 of about 1,568 (147)
The Emerging Roles of Metabolite-Activated GPCRs in Teleost Physiology and Aquaculture Development [PDF]
MetabolitesMetabolites, once viewed mainly as energy substrates or structural precursors, are now increasingly recognized as key extracellular signaling mediators that regulate diverse physiological processes.
Guan-Yuan Wei +6 more
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Succinate metabolism: underlying biological mechanisms and emerging therapeutic targets in inflammatory bowel disease [PDF]
Frontiers in ImmunologyThe global incidence of inflammatory bowel disease (IBD) continues to rise, yet its precise pathogenesis remains incompletely understood. In recent years, various gut microbiota-derived metabolites have been implicated in the development of IBD.
Mingzhu Dai +3 more
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Gut commensal bacterium Bacteroides vulgatus exacerbates helminth-induced cardiac fibrosis through succinate accumulation. [PDF]
PLoS PathogensTrichinella spiralis (Ts) is known to cause cardiac fibrosis, which is a critical precursor to various heart diseases, and its progression is influenced by metabolic changes. However, the metabolic mechanisms remain unclear.
Jiaqi Wang +4 more
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Succinate Regulates Exercise‐Induced Muscle Remodelling by Boosting Satellite Cell Differentiation Through Succinate Receptor 1 [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Skeletal muscle remodelling can cause clinically important changes in muscle phenotypes. Satellite cells (SCs) myogenic potential underlies the maintenance of muscle plasticity. Accumulating evidence shows the importance of succinate in muscle
Yifan Shi +7 more
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The Journal of Clinical InvestigationPancreatic β cell dysfunction is a key feature of type 2 diabetes, and novel regulators of insulin secretion are desirable. Here, we report that succinate receptor 1 (SUCNR1) is expressed in β cells and is upregulated in hyperglycemic states in mice and ...
Joan Sabadell-Basallote +19 more
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Prevotella copri promotes white adipose browning and ameliorates adiposity [PDF]
Nature CommunicationsPrevotella is a poorly understood symbiont within the gut microbiota, and its role in host health remains unclear. Here, we report a case-control analysis of a Chinese cohort, in which patients with obesity showed significantly lower fecal Prevotella ...
Shuang Liu +17 more
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A succinate/SUCNR1-brush cell defense program in the tracheal epithelium [PDF]
Science Advances, 2023 Host-derived succinate accumulates in the airways during bacterial infection. Here, we show that luminal succinate activates murine tracheal brush (tuft) cells through a signaling cascade involving the succinate receptor 1 (SUCNR1), phospholipase Cβ2, and the cation channel transient receptor potential channel subfamily M member 5 (TRPM5).
Perniss, Alexander +19 more
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Pharmacological Research, 2023 Succinate is a vital signaling metabolite produced by the host and gut microbiota. Succinate has been shown to regulate host metabolic homeostasis and inhibit obesity-associated inflammation in macrophages by engaging its cognate receptor, SUCNR1 ...
Xuan Li +6 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative.
Dieter M. Matlac +23 more
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P030 SUCNR1 mediates inflammasome activation: Relevance in Ulcerative Colitis [PDF]
Journal of Crohn's and Colitis, 2021 Abstract Background Ulcerative colitis (UC) is characterized by a diffuse, continuous, and chronic inflammation of mucosa and submucosa layers in the colon1. Inflammasome complex is involved in the intestinal homeostasis regulation, but its role in UC has not been established yet.
C Bauset +7 more
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