Succinate Promotes M1 Polarization of Intestinal Macrophages in Mice With Necrotizing Enterocolitis Through the PI3K/AKT Pathway [PDF]
Pediatric DiscoveryNecrotizing enterocolitis (NEC) is a devastating gastrointestinal disorder that frequently affects premature infants, and its pathogenesis is closely related to macrophage polarization.
Sha Liu +6 more
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Succinate in innate immunity: linking metabolic reprogramming to immune modulation [PDF]
Frontiers in ImmunologySuccinate is an essential metabolite in the tricarboxylic acid (TCA) cycle. In mitochondria, succinate holds a unique position connecting the TCA cycle and the electron transport chain (ETC), thereby providing a shortcut path for adenosine triphosphate ...
Reham Atallah +2 more
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The Emerging Roles of Metabolite-Activated GPCRs in Teleost Physiology and Aquaculture Development [PDF]
MetabolitesMetabolites, once viewed mainly as energy substrates or structural precursors, are now increasingly recognized as key extracellular signaling mediators that regulate diverse physiological processes.
Guan-Yuan Wei +6 more
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Succinate metabolism: underlying biological mechanisms and emerging therapeutic targets in inflammatory bowel disease [PDF]
Frontiers in ImmunologyThe global incidence of inflammatory bowel disease (IBD) continues to rise, yet its precise pathogenesis remains incompletely understood. In recent years, various gut microbiota-derived metabolites have been implicated in the development of IBD.
Mingzhu Dai +3 more
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Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression [PDF]
Signal Transduction and Targeted TherapyColorectal cancer (CRC) is a prevalent malignant tumor, and its pathogenesis has not yet been fully elucidated. The tumor microenvironment (TME) and ferroptosis in cancer cells are key drivers of tumor progression and metastasis.
Wentao Li +7 more
doaj +2 more sources
Prevotella copri promotes white adipose browning and ameliorates adiposity [PDF]
Nature CommunicationsPrevotella is a poorly understood symbiont within the gut microbiota, and its role in host health remains unclear. Here, we report a case-control analysis of a Chinese cohort, in which patients with obesity showed significantly lower fecal Prevotella ...
Shuang Liu +17 more
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Targeting ARF6-SUCNR1 Axis: Antisense Oligonucleotide Adjuvants for Neutrophil Immunometabolism. [PDF]
Int J Mol SciConventional vaccine adjuvants often lack cell-type specificity and readily trigger excessive systemic inflammation, limiting their clinical application.
Wang Y, Chen Y.
europepmc +2 more sources
Pharmacological Research, 2023 Succinate is a vital signaling metabolite produced by the host and gut microbiota. Succinate has been shown to regulate host metabolic homeostasis and inhibit obesity-associated inflammation in macrophages by engaging its cognate receptor, SUCNR1 ...
Xuan Li +6 more
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Frontiers in Endocrinology, 2021 Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative.
Dieter M. Matlac +23 more
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Frontiers in Immunology, 2022 Inflammation is an important driver of atherosclerosis. Succinate is a new extracellular inflammatory alarm released by activated macrophages. Succinate is sensed by succinate receptor 1 (Sucnr1) and then transferred to effector cells.
Jingwen Xu +9 more
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