Results 31 to 40 of about 1,568 (147)

Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis

Frontiers in Immunology, 2022
Inflammation is an important driver of atherosclerosis. Succinate is a new extracellular inflammatory alarm released by activated macrophages. Succinate is sensed by succinate receptor 1 (Sucnr1) and then transferred to effector cells.
Jingwen Xu, Yabing Zheng, Yaqing Zhao, Yujiao Zhang, Huilin Li, An Zhang, Xuehan Wang, Weizong Wang, Yinglong Hou, Jiangrong Wang   +9 more
doaj   +1 more source

Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development

Cells, 2020
The pathogenesis of Crohn’s disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its receptor (SUCNR1) are involved in intestinal inflammation and fibrosis, we investigated their ...
Dolores Ortiz-Masiá, Laura Gisbert-Ferrándiz, Cristina Bauset, Sandra Coll, Céline Mamie, Michael Scharl, Juan V. Esplugues, Rafael Alós, Francisco Navarro, Jesús Cosín-Roger, María D. Barrachina, Sara Calatayud   +11 more
doaj   +1 more source

DOP87 SUCNR1 a novel key protagonist in fistula development [PDF]

Journal of Crohn's and Colitis, 2020
Abstract Background Intestinal fistula is a common complication in CD patients whose aetiology is still not well-characterised. It is associated with an exacerbated inflammation and epithelial-to-mesenchymal transition (EMT), a process which allows a switch from epithelial towards a fibrotic behaviour.
Bauset, C, Gisbert-Ferrandiz, L, Ortiz-Masia, D, Coll, S, Mamie, C, Scharl, M, Calatayud, S, Barrachina, M D, Cosín-Roger, J   +8 more
openaire   +2 more sources

SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes. [PDF]

Sci Adv
Succinate, a mitochondrial metabolite, also functions as an extracellular signal through its receptor succinate receptor 1 (SUCNR1), coordinating responses to nutrient availability. The physiological role of SUCNR1 within hepatocytes, however, is unclear. We show that hepatic succinate levels and Sucnr1
Marsal-Beltran A, Salmerón-Pelado L, Ribas-Latre A, Repollés-de-Dalmau M, Rodríguez-Peña MM, Núñez-Roa C, Badia J, Madeira A, Novoa E, Beltrà M, Plata-Gómez AB, Capellades J, Escolà-Gil JC, Zorzano A, Yanes Ó, Efeyan A, Nogueiras R, Gracia-Sancho J, Vendrell J, Ceperuelo-Mallafré V, Fernández-Veledo S.   +20 more
europepmc   +2 more sources

Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle

American Journal of Physiology-Endocrinology and Metabolism, 2023
Macrophages but not skeletal muscle cells respond to extracellular succinate via SUCNR1/GPR91.
Abdelmoez, AM, Dmytriyeva, O, Zurke, Y-X, Trauelsen, M, Marica, AA, Savikj, M, Smith, JAB, Monaco, C, Schwartz, TW, Krook, A, Pillon, NJ   +10 more
openaire   +3 more sources

Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis. [PDF]

Am J Physiol Lung Cell Mol Physiol
This paper highlights the role of the succinate/SUCNR1 axis in pulmonary fibrosis. Receptor activation leads to profibrotic changes in IPF patient-derived fibroblasts. This finding could also be replicated in a mouse model of pulmonary fibrosis.
Rajesh R, Mooslechner AA, Schweighofer H, Pahernik S, Lanz I, Atallah R, Platzer W, Aigner C, Benazzo A, Angiari S, Marsh L, Kwapiszewska G, Heinemann A, Bärnthaler T.   +13 more
europepmc   +3 more sources

Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization

Journal of Neuroinflammation, 2023
Pathological neovascularization is a pivotal biological process in wet age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR), in which macrophages (Mφs) play a key role.
Tianyi Shen, Ruoyi Lin, Chengyu Hu, Donghui Yu, Chengda Ren, Tingting Li, Meijiang Zhu, Zhongqi Wan, Tu Su, Yan Wu, Wenting Cai, Jing Yu   +11 more
doaj   +1 more source

G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice

Cells, 2023
The TCA cycle intermediate metabolite ‘succinate’ has been proposed as an inflammatory mediator, influencing autoimmunity and allergic reactions, through ligation to its sensing receptor SUCNR1/GPR91.
Silke Griepke, Mette Trauelsen, Michelle D. Nilsson, Jakob Hansen, Lasse B. Steffensen, Thue W. Schwartz, Daniel F. J. Ketelhuth   +6 more
doaj   +1 more source

Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations [PDF]

Endocrinology and Metabolism, 2020
Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory ...
Yuqi Guo, Sun Wook Cho, Deepak Saxena, Xin Li   +3 more
doaj   +1 more source

SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes [PDF]

Diabetologia, 2017
Obesity induces macrophages to drive inflammation in adipose tissue, a crucial step towards the development of type 2 diabetes. The tricarboxylic acid (TCA) cycle intermediate succinate is released from cells under metabolic stress and has recently emerged as a metabolic signal induced by proinflammatory stimuli.
van Diepen, Janna A., Robben, Joris H., Hooiveld, Guido J., Carmone, Claudia, Alsady, Mohammad, Boutens, Lily, Bekkenkamp-Grovenstein, Melissa, Hijmans, Anneke, Engelke, Udo F.H., Wevers, Ron A., Netea, Mihai G., Tack, Cees J., Stienstra, Rinke, Deen, Peter M.T.   +13 more
openaire   +6 more sources