Results 41 to 50 of about 1,930 (160)
Role of succinate receptor (SUCNR1/GPR91) in the immunopathology of psoriasis
, 2021 O succinato é um ácido dicarboxílico intermediário do ciclo de Krebs que desempenha uma função importante no metabolismo energético celular. Além de suas funções metabólicas, o succinato também realiza diversas funções ao interagir com seu receptor de ...
Assunção, Stella Francy Vicente de
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P030 SUCNR1 mediates inflammasome activation: Relevance in Ulcerative Colitis [PDF]
Journal of Crohn's and Colitis, 2021 Abstract Background Ulcerative colitis (UC) is characterized by a diffuse, continuous, and chronic inflammation of mucosa and submucosa layers in the colon1. Inflammasome complex is involved in the intestinal homeostasis regulation, but its role in UC has not been established yet.
C Bauset +7 more
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Cells, 2023 The TCA cycle intermediate metabolite ‘succinate’ has been proposed as an inflammatory mediator, influencing autoimmunity and allergic reactions, through ligation to its sensing receptor SUCNR1/GPR91.
Silke Griepke +6 more
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Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations [PDF]
Endocrinology and Metabolism, 2020 Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory ...
Yuqi Guo +3 more
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Journal of Neuroinflammation, 2023 Pathological neovascularization is a pivotal biological process in wet age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR), in which macrophages (Mφs) play a key role.
Tianyi Shen +11 more
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Metabolites, 2021 Succinate is a metabolite in the tricarboxylic acid cycle (TCA) which plays a central role in mitochondrial activity. Excess succinate is known to be transported out of the cytosol, where it activates a succinate receptor (SUCNR1) to enhance inflammation
Lixiang Wang +5 more
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Targeted Disruption of the SUCNR1 Metabolic Receptor Leads to Dichotomous Effects on Obesity [PDF]
Diabetes, 2014 A number of metabolites have signaling properties by acting through G-protein–coupled receptors. Succinate, a Krebs cycle intermediate, increases after dysregulated energy metabolism and can bind to its cognate receptor succinate receptor 1 (Sucnr1, or GPR91) to activate downstream signaling pathways.
McCreath, KJ +6 more
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Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages
Metabolites, 2020 Immunometabolism revealed the crucial role of cellular metabolism in controlling immune cell phenotype and functions. Macrophages, key immune cells that support progression of numerous inflammatory diseases, have been well described as undergoing vast ...
Karl J. Harber +7 more
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Succinate aggravates intestinal injury in mice with necrotizing enterocolitis
Frontiers in Cellular and Infection Microbiology, 2022 BackgroundNecrotizing enterocolitis (NEC) is the most prevalent gastrointestinal disorder that predominantly threatens preterm newborns. Succinate is an emerging metabolic signaling molecule that was recently studied in relation to the regulation of ...
Xiao-Lin Yan +8 more
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The Role of Succinic Acid Metabolism in Ovarian Cancer
Frontiers in Oncology, 2021 Ovarian cancer is one of the most common malignancies and the highest mortality among gynecological malignancy. The standard therapy options for patients with ovarian cancer are cytoreductive surgery and chemotherapy, and although most patients do better
Lei Xia +4 more
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