Results 61 to 70 of about 1,930 (160)

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Influenza‐induced tuft cell expansion is associated with changes in ILC2 populations in the distal lungs of mice

Physiological Reports, Volume 14, Issue 13, July 2026.
Abstract Tuft cells act as sentinels that amplify type 2 inflammation primarily by activating type 2 innate lymphoid cells (ILC2s). Although normally absent from the distal lung, ectopic tuft cells form after severe lung injury including influenza infection in mice.
Maria Elena Gentile, Michael M. Maiden, Evelyn A. Martinez, Madeline Singh, Harshini Kelam, Nicolas P. Holcomb, Meryl Mendoza, Joanna Wong, Diana M. Abraham, Alena Klochkova, Sara Kass‐Gergi, Andrew E. Vaughan   +11 more
wiley   +1 more source

Succinate/SUCNR1-mediated regulation of macrophage polarization reduces trophoblast apoptosis: A potential cause of retained placenta in peripartal dairy cows

Journal of Dairy Science
: Retained placenta (RP) is recognized as a multifactorial postpartal reproductive disorder in dairy cows. Trophoblast dysfunction and abnormal macrophage activation at the maternal-fetal interface are associated with occurrence of RP.
Huijing Zhang, Ming Li, Bichen Zhao, Renxu Chang, Jingyi Wang, Qingnian Huang, Shihao Song, Wenda Wu, Juan J. Loor, Chuang Xu   +9 more
doaj   +1 more source

Succinate as a New Actor in Pluripotency and Early Development?

Metabolites, 2022
Pluripotent cells have been stabilized from pre- and post-implantation blastocysts, representing respectively naïve and primed stages of embryonic stem cells (ESCs) with distinct epigenetic, metabolic and transcriptomic features.
Damien Detraux, Patricia Renard
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Management succinate release through SDHA by G protein-coupled receptor 91 signal, TRAP1, and SIRT3 regulation in lung cancer cells by NAR nanoparticles

Journal of Genetic Engineering and Biotechnology
Background: Cancer cells display oxidative metabolic dysregulation to fulfill their bioenergy requirements. Specifically, efforts were made to regulate the metabolite succinate and its negative effects as an inducer for neoplasm invasion and metastasis ...
Eman M. Ragab, Abeer A. Khamis, Tarek M. Mohamed, Doaa M. El Gamal   +3 more
doaj   +1 more source

Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis

American Journal of Physiology-Lung Cellular and Molecular Physiology
This paper highlights the role of the succinate/SUCNR1 axis in pulmonary fibrosis. Receptor activation leads to profibrotic changes in IPF patient-derived fibroblasts. This finding could also be replicated in a mouse model of pulmonary fibrosis.
Rishi Rajesh, Agnes Anna Mooslechner, Hannah Schweighofer, Svetlana Pahernik, Ilse Lanz, Reham Atallah, Wolfgang Platzer, Clemens Aigner, Alberto Benazzo, Stefano Angiari, Leigh Marsh, Grazyna Kwapiszewska, Akos Heinemann, Thomas Bärnthaler   +13 more
openaire   +2 more sources

Mesenteric Adipose Tissue as a Modulator of Intestinal Inflammation: Mechanistic Insights and Model Systems in Crohn's Disease

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review explores how mesenteric adipose tissue, particularly creeping fat, contributes to intestinal inflammation through dysregulated adipokine signalling. We explore how metabolic stress alters immune‐adipose interactions and promotes disease progression.
Toka Omar, Carl Weidinger, Britta Siegmund   +2 more
wiley   +1 more source

Compressive force-induced succinate production via metabolic reprogramming in periodontal ligament cells promotes orthodontic tooth movement

Progress in Orthodontics
Objective This study aimed to elucidate metabolic alterations in gingival crevicular fluid (GCF) during orthodontic tooth movement (OTM) and investigate the role of the succinate-SUCNR1 axis in bone resorption and tooth movement.
Jiahong Shi, Lulu Wang, Liliang Shan, Meng Zhu, Yu Chen, Houxuan Li, Lang Lei   +6 more
doaj   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source