Results 61 to 70 of about 1,568 (147)

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, Volume 7, Issue 3, June 2026.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Aging‐Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment

Aging Cell, Volume 25, Issue 5, May 2026.
In the aged ovarian TME, cancer cells exhibit increased succinate production. Elevated extracellular succinate activates the SUCNR1 receptor on Tregs, promoting their recruitment and contributing to an immunosuppressive environment. This leads to diminished anti‐tumor T cell responses and reduced survival.
Mary P. Udumula, Anjaly KM, Faraz Rashid, Mohammad Nematullah, Harshit Singh, Tanya Bhardwaj, Miriana Hijaz, Shailendra Giri, Eduardo N. Chini, Heather M. Gibson, Ramandeep Rattan   +10 more
wiley   +1 more source

Fusobacterium nucleatum-derived succinic acid aggravates colitis by triggering macrophage pro-inflammatory phenotypic transformation via SUCNR1/NF-κB axis

Gut Microbes
Fusobacterium nucleatum (F. nucleatum) has been increasingly implicated in the pathogenesis of inflammatory bowel disease (IBD), yet the mechanisms underlying its effects remain incompletely defined.
Suqi Zeng, Shanshan Jiang, Jianxuan Sun, Yan Chen, Meiqi Qiu, Jiao Li, Qingzhi Lan, Yu Pu, Zongbiao Tan, Xingzhou Guo, Haodong He, Shuo Wang, Luyun Zhang, Yafei Liu, Jiaming Hu, Ruxue Wang, Fei Liao, Jixiang Zhang, Weiguo Dong   +18 more
doaj   +1 more source

The Crosstalk Mechanisms Between Ferroptosis and Pyroptosis and Their Applications in Diseases: From Molecular Networks to Clinical Strategies

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Ferroptosis and pyroptosis are two distinct forms of regulated cell death that play crucial roles in cancer, neurodegeneration, and inflammatory diseases. Ferroptosis is characterised by iron‐dependent lipid peroxidation, while pyroptosis is an inflammatory cell death mediated by gasdermin proteins.
Wei‐Yi Zhao, Lu‐yao Li, Fang‐wang Ye, Jin‐Wei Zhao   +3 more
wiley   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, Volume 2, Issue 1, March 2026.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Сукцинатные рецепторы (SUCNR1) как перспективная мишень фармакотерапии

Химико-фармацевтический журнал, 2015
В последние годы проведено немало исследований, посвященных рецепторам, сопряженным с G-белками, их расположению в организме, механизму активации и возможным путям фармакологического воздействия. Интермедианты углеводного, жирового и белкового обменов, цикла трикарбоновых кислот в качестве эндогенных лигандов к большой группе экс-орфанных рецепторов ...
openaire   +2 more sources

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

Nature Immunology, 2019
Succinate is a signaling metabolite sensed extracellularly by succinate receptor 1 (SUNCR1). The accumulation of succinate in macrophages is known to activate a pro-inflammatory program; however, the contribution of SUCNR1 to macrophage phenotype and function has remained unclear.
Noelia Keiran, Victoria Ceperuelo-Mallafré, Enrique Calvo, Maria Isabel Hernández-Alvarez, Miriam Ejarque, Catalina Núñez-Roa, Daniel Horrillo, Elsa Maymó-Masip, M. Mar Rodríguez, Rosa Fradera, Juan Vladimir de la Rosa, Rosa Jorba, Ana Megia, Antonio Zorzano, Gema Medina-Gómez, Carolina Serena, Antonio Castrillo, Joan Vendrell, Sonia Fernández-Veledo   +18 more
openaire   +6 more sources

The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage

Cell Communication and Signaling
Background Renal fibrosis significantly contributes to the progressive loss of kidney function in chronic kidney disease (CKD), with alternatively activated M2 macrophages playing a crucial role in this progression.
Min Pu, Jing Zhang, Fuyan Hong, Yan Wang, Chengwei Zhang, Yongcheng Zeng, Zhenzhen Fang, Weiwei Qi, Xia Yang, Guoquan Gao, Ti Zhou   +10 more
doaj   +1 more source

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

Molecular Metabolism, 2017
Objective: Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools.
Mette Trauelsen, Elisabeth Rexen Ulven, Siv A. Hjorth, Matjaz Brvar, Claudia Monaco, Thomas M. Frimurer, Thue W. Schwartz   +6 more
doaj   +1 more source