Results 81 to 90 of about 1,568 (147)

Lactobacillus salivarius metabolite succinate enhances chicken intestinal stem cell activities via the SUCNR1-mitochondria axis

Poultry Science
The activity of intestinal stem cells (ISCs) can be modulated by Lactobacillus, which subsequently affects the mucosal absorptive capacity. However, the underlying mechanisms remain unclear.
Danni Luo, Minyao Zou, Xi Rao, Mingping Wei, Lingzhi Zhang, Yuping Hua, Lingzi Yu, Jiajia Cao, Jinyi Ye, Sichao Qi, Huanan Wang, Yuling Mi, Caiqiao Zhang, Jian Li   +13 more
doaj   +1 more source

Fueling bone loss: the immunometabolic reprogramming of the bone microenvironment in diabetic osteoporosis

Frontiers in Immunology
Diabetic osteoporosis (DOP) is a serious skeletal complication of type 2 diabetes mellitus (T2DM), characterized by deteriorated bone microarchitecture and elevated fracture risk independent of reduced bone mineral density.
Yunfang Wang, Yunfang Wang, Yunfang Wang, Jinwen Han, Jinwen Han, Zheng Wang, Gai Zhang, Ruilan Niu, Ruilan Niu, Yaqing Wei, Yaqing Wei, Kang Yi, Kang Yi, Jinxing Quan, Jinxing Quan, Jinxing Quan   +15 more
doaj   +1 more source

Regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity

Frontiers in Immunology
The intestinal mucosal immune system maintains homeostasis through complex interactions between epithelial cells and innate lymphoid cells in the lamina propria.
Kaiyu Shang, Xinxin Qi, Tingting Tian, Huidong Shi, Yuejie Zhu, Fengbo Zhang   +5 more
doaj   +1 more source

Succinate predisposes mice to atrial fibrillation by impairing mitochondrial function via SUCNR1/AMPK axis

Redox Biology
Atrial fibrillation (AF), a major public health concern, is associated with high rates of death and disability. Mitochondrial dysfunction has emerged as a key contributor to the pathophysiology of AF.
Yudi Zhang, Haoyu Gong, Lingyan Jin, Peng Liu, Jiali Fan, Xinghua Qin, Qiangsun Zheng   +6 more
doaj   +1 more source

Mechanisms Involved in Pathological Succinate-Mediated Signaling. [PDF]

Int J Mol Sci
Bernabe-Yepes B, Zazueta C.
europepmc   +1 more source

Microglial succinate receptor 1 (SUCNR1) sustains chronic CNS inflammation

The rapidly evolving field of immunometabolism has shed new light on new fundamental properties of metabolites, which can regulate inflammation via ligand-receptor signalling modalities. Among these, succinate signalling via succinate receptor 1 (SUCNR1) plays a key role in controlling myeloid cells responses in systemic inflammatory conditions ...
openaire   +2 more sources

Vascular changes and their implications in lipedema. [PDF]

Front Cell Dev Biol
Al-Ghadban S, Guo Y, Juskiewicz ZJ, Crescenzi R, Li X, Isakson BE, Hollenbeck ST.   +6 more
europepmc   +1 more source

Metabolite-neuro-immune relay in chronic pain: spatial-temporal lactate, succinate and itaconate signalling as drivers of glial reprogramming and neuronal sensitisation. [PDF]

Front Pharmacol
Hu Z, Ji Q, Xiong Q, Ning Y, Rao Y, Fu J, Wang L, Xiong X, Ou C, Zhang Y.   +9 more
europepmc   +1 more source

The role and therapeutic potential of succinate and succinylation in cardiovascular diseases. [PDF]

Clin Epigenetics
Liu W, Han Y, Zhang F, Leng S, Yu W.
europepmc   +1 more source

Extracellular Succinate Modulates Neuroimmune Responses in a Murine Microglial Cell Line. [PDF]

Biomolecules
Yudin SCY, Day K, Scott EY, Patel MN, Islam H, Klegeris A.   +5 more
europepmc   +1 more source