Results 81 to 90 of about 1,930 (160)

Bisphenol AF Induces Hepatic Steatosis via Succinate-SUCNR1-Mediated Macrophage-Hepatocyte Interactions: An Adverse Outcome Pathway Study in Male C57BL/6 Mice. [PDF]

Int J Mol Sci
Bisphenol AF (BPAF) exposure is increasingly linked to metabolic disorders, yet the molecular initiating events (MIE) and key events (KE) leading to hepatic steatosis remain unclear.
Wang N, Leng J, Zhang H, Xu J, Yu X, Qian K, Zheng Z, Ying M, Tao G, Xiao P, Hong X.   +10 more
europepmc   +2 more sources

Gut commensal bacterium Bacteroides vulgatus exacerbates helminth-induced cardiac fibrosis through succinate accumulation.

PLoS Pathogens
Trichinella spiralis (Ts) is known to cause cardiac fibrosis, which is a critical precursor to various heart diseases, and its progression is influenced by metabolic changes. However, the metabolic mechanisms remain unclear.
Jiaqi Wang, Jiali Yin, Xiaolei Liu, Yi Liu, Xuemin Jin   +4 more
doaj   +1 more source

Succinate Receptor 1 (SUCNR1/GPR91) Expression in CD11c+ Cells Promotes Protection to the Leishmania amazonensis Infection

A leishmaniose cutânea (CL) é uma doença infecciosa negligenciada prevalente no Brasil, onde é causada principalmente por L. braziliensis e L. amazonensis. Os tratamentos disponíveis são crônicos e podem levar à resistência dos parasitas. Considerando as
Assunção, Stella Francy Vicente de
core   +1 more source

Coexpression network analysis of platelet genes in sickle cell disease

Platelets, 2019
Platelets play important roles in vascular health. Activation of platelet may contribute to coagulation and inflammation. Evidence suggests circulating platelets are chronically activated in sickle cell disease (SCD) patients with steady state and ...
Fang-Fang Liu, Tong-Tao Tu, Hong-Feng Zhang, Fan Hu, Liang Huang, Lin-Feng Deng, Mao Guo, Qing Wei, Ke Li   +8 more
doaj   +1 more source

Extracellular succinate derived from ectopic milieu drives adhesion and implantation growth of ectopic endometrial stromal cells via the SUCNR1 signal in endometriosis

Cell Communication and Signaling
Background As a dual-function metabolite, succinate has emerged in cell function and plays a key signaling role in linking mitochondrial function to other cellular functions.
Qi Tian, Jingyao Ruan, Yuning Wang, Yinping Xiao, Qi Cheng, Yun Chen, Mingqing Li, Kaikai Chang, Xiaofang Yi   +8 more
doaj   +1 more source

Succinate receptor 1 (GPCR91; SUCNR1) [PDF]

Science-Business eXchange, 2008
openaire   +3 more sources

Caracterización del papel del succinato y su receptor SUCNR1 en la fisiopatología de la obesidad y la diabetes de tipo 2 [PDF]

, 2021
L’eix succinat-SUCNR1 ha cobrat especial interès per la seva implicació en diverses patologies inflamatòries cròniques, com l'obesitat i la diabetis tipus 2 (T2D).
Keiran Fernández, Noelia
core  

OP027 SUCNR1 receptor mediates intestinal fibrosis [PDF]

Journal of Crohn's and Colitis, 2018
J Cosin-Roger, D Ortiz-Masia, D C Macias-Ceja, L Gisbert-Ferrandiz, P Salvador, M Hausmann, G Rogler, S Calatayud, M D Barrachina   +8 more
openaire   +1 more source

The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions.

Frontiers in Endocrinology, 2012
The succinate receptor (also known as GPR91) is a G protein-coupled receptor that is closely related to the family of P2Y purinoreceptors. It is expressed in a variety of tissues, including blood cells, adipose tissue, the liver, retina and kidney.
Ana Carolina eAriza, Peter M.T. Deen, Joris Hubertus Robben   +2 more
doaj   +1 more source

Estudio del succinato y su receptor SUCNR1 como potenciales biomarcadores metabólicos en la fisiopatología de la obesidad.

, 2022
Actualmente el eje succinato-SUCNR1 interviene en distintas patologías inflamatorias metabólicas crónicas, como la obesidad, es por esto que en condiciones de estrés oxidativo la alteración en el funcionamiento del ciclo de los ácidos tricarboxílicos ...
Balarezo Espinoza, Fabiana Madelaine
core   +1 more source