Results 91 to 100 of about 1,930 (160)

Conception, synthèse et identification de ligands pour SUCNR1 et GPR22

, 2016
G protein coupled receptors (GPCR) are the largest family of membrane receptors and currently the most successfully targeted protein for therapeutic purposes. However, many remain uncharacterized.
Dupuis, Nadine, Soni, Arvind, Geubelle, Pierre, Gilissen, Julie, Laschet, Céline, Pirotte, Bernard, Derj, Anouar, Hanson, Julien   +7 more
core   +1 more source

Lactobacillus salivarius metabolite succinate enhances chicken intestinal stem cell activities via the SUCNR1-mitochondria axis

Poultry Science
The activity of intestinal stem cells (ISCs) can be modulated by Lactobacillus, which subsequently affects the mucosal absorptive capacity. However, the underlying mechanisms remain unclear.
Danni Luo, Minyao Zou, Xi Rao, Mingping Wei, Lingzhi Zhang, Yuping Hua, Lingzi Yu, Jiajia Cao, Jinyi Ye, Sichao Qi, Huanan Wang, Yuling Mi, Caiqiao Zhang, Jian Li   +13 more
doaj   +1 more source

Identification of modulators for SUCNR1 by screening of a SOSA library with a bioluminescent cAMP assay

, 2014
Background Succinic acid (SA), a metabolic component that takes part in the citric acid cycle, has been described as the cognate agonist for the orphan receptor SUCNR1 (GPR91).
Dupuis, Nadine, Soni, Arvind, Gilissen, Julie, Pirotte, Bernard, Dilly, Sebastien, Derj, Anouar, Hanson, Julien   +6 more
core   +1 more source

The Succinate-SUCNR1 Axis and Its Impact on Beta-Cell Function: An Integrative Study Uncovering Novel Insights into Insulin Secretion Regulation and Diabetes Pathogenesis

, 2023
La disfunció de les cèl·lules β pancreàtiques constitueix una característica fonamental de la diabetis tipus 2 (DT2) i descobrir nous reguladors de la secreció d'insulina és essencial.
Sabadell i Basallote, Joan-Martí
core  

Succinate predisposes mice to atrial fibrillation by impairing mitochondrial function via SUCNR1/AMPK axis

Redox Biology
Atrial fibrillation (AF), a major public health concern, is associated with high rates of death and disability. Mitochondrial dysfunction has emerged as a key contributor to the pathophysiology of AF.
Yudi Zhang, Haoyu Gong, Lingyan Jin, Peng Liu, Jiali Fan, Xinghua Qin, Qiangsun Zheng   +6 more
doaj   +1 more source

Metabolic Impact of the Succinate/SUCNR1 Axis in Adipocytes: Insights into Circadian and Leptin Regulation [PDF]

El teixit adipós (AT) és clau per al manteniment de l'equilibri energètic mitjançant la secreció de leptina, hormona que regula la homeòstasi energètica i l'adipositat corporal.
Villanueva Carmona, Teresa
core  

Regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity

Frontiers in Immunology
The intestinal mucosal immune system maintains homeostasis through complex interactions between epithelial cells and innate lymphoid cells in the lamina propria.
Kaiyu Shang, Xinxin Qi, Tingting Tian, Huidong Shi, Yuejie Zhu, Fengbo Zhang   +5 more
doaj   +1 more source

Deficiency in the Metabolite-Sensing Receptor SUCNR1 (GPR91) Leads to Outer Retinal Lesions akin to dry-Age-Related Macular Degeneration

, 2013
Age-related macular degeneration (AMD) is a prominent cause of blindness in the Western world. To date, its molecular pathogenesis as well as the sequence of events leading to retinal degeneration remain largely ill-defined.
Favret, Sandra, Carballido, Jose, Sapieha, Przemyslaw, Rubic-Schneider, Tina   +3 more
core  

Role of the succinate/Sucnr1 signaling pathway in primary sensory neurons in the pathophysiology of paclitaxel-induced neuropathic pain

A dor neuropática é uma doença do sistema somatossensorial que pode ser causada por danos mecânicos, biológicos, metabólicos ou químicos. Os agentes antineoplásicos são neurotóxicos aos neurônios sensoriais primários, causam axonopatia em indivíduos sob ...
Gomes, Francisco Isaac Fernandes
core   +1 more source

<i>Sucnr1</i> Mediates Leukocyte-Endothelial Cell Interactions Induced by Tnfα. [PDF]

Int J Mol Sci
Coll S, Jarén A, Bauset C, Macias-Ceja DC, Ortiz-Masiá D, Cosín-Roger J, Barrachina MD, Calatayud S.   +7 more
europepmc   +1 more source