Results 71 to 80 of about 1,568 (147)

LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases

MedComm, Volume 7, Issue 3, March 2026.
The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Coexpression network analysis of platelet genes in sickle cell disease

Platelets, 2019
Platelets play important roles in vascular health. Activation of platelet may contribute to coagulation and inflammation. Evidence suggests circulating platelets are chronically activated in sickle cell disease (SCD) patients with steady state and ...
Fang-Fang Liu, Tong-Tao Tu, Hong-Feng Zhang, Fan Hu, Liang Huang, Lin-Feng Deng, Mao Guo, Qing Wei, Ke Li   +8 more
doaj   +1 more source

Extracellular succinate derived from ectopic milieu drives adhesion and implantation growth of ectopic endometrial stromal cells via the SUCNR1 signal in endometriosis

Cell Communication and Signaling
Background As a dual-function metabolite, succinate has emerged in cell function and plays a key signaling role in linking mitochondrial function to other cellular functions.
Qi Tian, Jingyao Ruan, Yuning Wang, Yinping Xiao, Qi Cheng, Yun Chen, Mingqing Li, Kaikai Chang, Xiaofang Yi   +8 more
doaj   +1 more source

Succinate-mediated metabolic alterations and signaling in RA: mechanisms and therapeutic implications

Frontiers in Immunology
Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation. Recent studies have revealed that immune metabolites, particularly succinate, play a critical role in its pathogenesis.
Yi Fan, Naidi Wang, Chenxu Zhao, Zhaoqi Zhang   +3 more
doaj   +1 more source

Succinate receptor 1 (GPCR91; SUCNR1) [PDF]

Science-Business eXchange, 2008
openaire   +3 more sources

The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions.

Frontiers in Endocrinology, 2012
The succinate receptor (also known as GPR91) is a G protein-coupled receptor that is closely related to the family of P2Y purinoreceptors. It is expressed in a variety of tissues, including blood cells, adipose tissue, the liver, retina and kidney.
Ana Carolina eAriza, Peter M.T. Deen, Joris Hubertus Robben   +2 more
doaj   +1 more source

OP027 SUCNR1 receptor mediates intestinal fibrosis [PDF]

Journal of Crohn's and Colitis, 2018
J Cosin-Roger, D Ortiz-Masia, D C Macias-Ceja, L Gisbert-Ferrandiz, P Salvador, M Hausmann, G Rogler, S Calatayud, M D Barrachina   +8 more
openaire   +1 more source