Succinate–GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD+ production to alleviate HFpEF [PDF]
Cardiovascular DiabetologyBackground Disrupted cardiomyocyte energy metabolism is a hallmark of heart failure with preserved ejection fraction (HFpEF). Succinate, a key intermediate of the tricarboxylic acid cycle, is markedly decreased in HFpEF myocardium.
Yumeng Jia +7 more
exaly +8 more sources
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91 [PDF]
Molecular Metabolism, 2017 Objective: Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools.
Matjaz Brvar +2 more
exaly +7 more sources
From inflammation to healing: the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recovery [PDF]
Stem Cell Research and TherapyBackground Diabetic foot ulcers (DFU) typically exhibit impaired healing due to dysregulated re-epithelialization and excessive inflammation. Succinate, a key metabolic intermediate, is now understood to regulate inflammation through G Protein-Coupled ...
Xuefeng He, Shixin Zhao, Hengdeng Liu
exaly +3 more sources
G protein-coupled receptor 91 activations suppressed mineralization in Porphyromonas gingivalis–infected osteoblasts [PDF]
Scientific ReportsSuccinate receptor GPR91 is one of the G protein-coupled receptors (GPCRs) that interacts with various proteins to regulate diverse cellular functions such as cell morphology, apoptosis, and differentiation.
Wenqi Su +4 more
doaj +3 more sources
Tricarboxylic Acid (TCA) Cycle Enzyme Alpha-Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization. [PDF]
J Cell BiochemABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Li M, Mailloux RJ.
europepmc +2 more sources
Metabolic Syndrome: From Mechanisms to Therapeutic Interventions. [PDF]
MedComm (2020)A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Yan M, Xiang Q.
europepmc +2 more sources
Polysaccharides and Glycosides from Aralia echinocaulis Modulate Succinate Levels in the Gut to Target Intestinal Dendritic Cells via the Receptor GPR91 in the Treatment of Rheumatoid Arthritis [PDF]
PharmaceuticalsBackground: Aralia echinocaulis has therapeutic effects on rheumatoid arthritis (RA), with total polysaccharide and glycoside (TPGs) as main active components. RA pathogenesis involves gut microbiota dysbiosis and immune–metabolic crosstalk, but the role
Mengqiang Gao, Shanshan Ma, Yunzhi Li
doaj +2 more sources
Metabolic rewiring through succinate–GPR91 signaling: a fresh perspective on HFpEF energetics [PDF]
Cardiovascular DiabetologySuccinate has recently emerged as a signaling metabolite that extends beyond its canonical role in the tricarboxylic acid (TCA) cycle to influence cellular adaptation and stress responses. In their study, Jia et al. identify the succinate-GPR91 axis as a
Marialucia Telesca +2 more
doaj +2 more sources
Tissue Immunometabolism in Autoimmunity. [PDF]
Eur J ImmunolThe tissue metabolic environment in autoimmunity influences immune and nonimmune cells via fuelling cellular metabolism or through metabolic signalling. Intracellular metabolic sensors combine several environmental cues to control transcription, metabolism, and cell function.
Villa M.
europepmc +2 more sources
Orphan GPCRs in diabetes mellitus: metabolic control, inflammation, and drug development [PDF]
Frontiers in EndocrinologyDiabetes mellitus (diabetes) is a major health burden with the highest mortality rate, affecting an estimated 537 million adults worldwide. The treatment of diabetes remains complex owing to insulin resistance, β-cell dysfunction, metabolic inflammation,
Sureka Chandrabose +5 more
doaj +2 more sources