Results 1 to 10 of about 77 (71)

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

Molecular Metabolism, 2017
Objective: Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools.
Matjaz Brvar, Thue W Schwartz, Siv Annegrethe Hjorth   +2 more
exaly   +3 more sources

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Cell Reports, 2021
Summary: Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate receptor SUCNR1. In the present study, we characterize and compare effects and signaling pathways
Anna Sofie Husted, Thue W Schwartz, Michel Bouvier   +2 more
exaly   +3 more sources

GPR91 Receptor Mediates Protection against Doxorubicin-Induced Cardiotoxicity without Altering Its Anticancer Efficacy. An In Vitro Study on H9C2 Cardiomyoblasts and Breast Cancer-Derived MCF-7 Cells

Cells, 2020
Doxorubicin (DOX) is an anticancer drug widely used in oncology, especially for breast cancer. The main limitation of DOX treatment is its cardiotoxicity due to the cumulative dose.
Corentin Schepkens, Vanessa Tagliatti, Jean-Marie Colet   +2 more
exaly   +3 more sources

Succinate–GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD+ production to alleviate HFpEF

Cardiovascular Diabetology
Background Disrupted cardiomyocyte energy metabolism is a hallmark of heart failure with preserved ejection fraction (HFpEF). Succinate, a key intermediate of the tricarboxylic acid cycle, is markedly decreased in HFpEF myocardium.
Du Jie
exaly   +2 more sources

From inflammation to healing: the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recovery

Stem Cell Research and Therapy
Background Diabetic foot ulcers (DFU) typically exhibit impaired healing due to dysregulated re-epithelialization and excessive inflammation. Succinate, a key metabolic intermediate, is now understood to regulate inflammation through G Protein-Coupled ...
Hanwen Wang, Shixin Zhao
exaly   +2 more sources

Succinate promotes pulmonary fibrosis through GPR91 and predicts death in idiopathic pulmonary fibrosis

Scientific Reports
Idiopathic pulmonary fibrosis (IPF) is believed to be associated with a notable disruption of cellular energy metabolism. By detecting the changes of energy metabolites in the serum of patients with pulmonary fibrosis, we aimed to investigate the ...
Lijian Tao, Guoliang Jiang, Cheng Xiaoyun   +2 more
exaly   +2 more sources

G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice

Cells, 2023
The TCA cycle intermediate metabolite ‘succinate’ has been proposed as an inflammatory mediator, influencing autoimmunity and allergic reactions, through ligation to its sensing receptor SUCNR1/GPR91.
Silke Griepke, Mette Trauelsen, Michelle D. Nilsson, Jakob Hansen, Lasse B. Steffensen, Thue W. Schwartz, Daniel F. J. Ketelhuth   +6 more
doaj   +1 more source

Increased succinate receptor GPR91 involved in the pathogenesis of Mooren’s ulcer [PDF]

International Journal of Ophthalmology, 2018
AIM: To investigate the expression of succinate receptor GPR91 and its pathogenic roles in Mooren’s ulcer (MU). METHODS: Biopsy specimens were obtained from 7 patients with MU and 6 healthy donors.
Lin Li, Yan-Ling Dong, Ting Liu, Dan Luo, Chao Wei, Wei-Yun Shi   +5 more
doaj   +1 more source

LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate-G-protein couple receptor 91 (GPR91) pathway in mice. [PDF]

PLoS ONE, 2018
Fibroblast growth factor 21 (FGF21) is an important metabolic regulator expressed predominantly in the liver. In this study, we evaluated the role of LY2405319, an analogue of FGF21, in hepatic stellate cell (HSC) activation and in a methionine and ...
Cong Thuc Le, Giang Nguyen, So Young Park, Dae Hee Choi, Eun-Hee Cho   +4 more
doaj   +1 more source

Bioinformatic analysis identifies GPR91 as a potential key gene in brain injury after deep hypothermic low flow

Heliyon, 2023
Purpose: Explore the transcription change of brain ischemia and reperfusion injury after deep hypothermic low flow. Method: The data from PRJNA739516 and GSE104036 were obtained for the differentially expressed genes identification, functional enrichment
Song Puwei, Xu Jiali, Deqin Zhuoga, Wu Kede, Nishant Patel, An Jia, Qi Jirong, Mo Xuming   +7 more
doaj   +1 more source