Results 31 to 40 of about 1,817 (168)
The role of the GPR91 ligand succinate in hematopoiesis [PDF]
Journal of Leukocyte Biology, 2009 AbstractRegulation of cellular metabolism by the citric acid cycle occurs in the mitochondria. However, the citric acid cycle intermediate succinate was shown recently to be a ligand for the G-protein-coupled receptor GPR91. Here, we describe a role for succinate and its receptor in the stimulation of hematopoietic progenitor cell (HPC) growth.
Yaron, Hakak +6 more
openaire +2 more sources
LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate-G-protein couple receptor 91 (GPR91) pathway in mice. [PDF]
PLoS ONE, 2018 Fibroblast growth factor 21 (FGF21) is an important metabolic regulator expressed predominantly in the liver. In this study, we evaluated the role of LY2405319, an analogue of FGF21, in hepatic stellate cell (HSC) activation and in a methionine and ...
Cong Thuc Le +4 more
doaj +1 more source
Biomedicines, 2022 Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using
Wei-Chia Lee +5 more
doaj +1 more source
Identification of lead compounds for 99mTc and 18F GPR91 radiotracers [PDF]
Bioorganic & Medicinal Chemistry Letters, 2015 To develop the first radiotracer targeting GPR91, a cell membrane-bound receptor that modulates the cellular response to hyperglycemia and hypoxia, we designed and prepared a small series of compounds based on a published series of 1,8-naphthyridines with high affinity to GPR91.
Jeffrey, Klenc +2 more
openaire +2 more sources
Cells, 2021 Succinate influences angiogenesis and neovascularization via a hormonelike effect on G-protein-coupled receptor 91 (GPR91). This effect has been demonstrated in the pathophysiology of diabetic retinopathy and rheumatoid arthritis.
Anaïs Moyon +9 more
doaj +1 more source
Science-Business eXchange, 2008 GPR91 has emerged as a key target in multiple diseases that involve inflammation or angiogenesis. Novartis is already pursuing agonists and antagonists of the GPCR.
openaire +1 more source
GPR91 triggers paracrine signaling in the JGA
The FASEB Journal, 2007 GPR91, a kidney‐specific metabolic receptor is expressed in the juxtaglomerular apparatus (JGA) and its activation by succinate causes renin release. We aimed to identify the mechanism of GPR91 signaling. Glomerular endothelial cells (GENC), but not vascular smooth muscle (VSMC) or JG cells in culture expressed GPR91 confirmed by ...
Ildiko Toma +5 more
openaire +1 more source
Cells, 2022 The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle metabolite succinate. GPCR signaling depends on the surrounding environment and intracellular localization through location bias.
Melanie Sanchez +21 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative.
Dieter M. Matlac +23 more
doaj +1 more source
Metformin: update on mechanisms of action on liver diseases
Frontiers in Nutrition, 2023 Substantial attention has been paid to the various effects of metformin on liver diseases; the liver is the targeted organ where metformin exerts its antihyperglycemic properties.
Gaoyi Ruan +5 more
doaj +1 more source