Results 31 to 40 of about 1,556 (139)
Frontiers in Endocrinology, 2021 Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative.
Dieter M. Matlac +23 more
doaj +1 more source
Metformin: update on mechanisms of action on liver diseases
Frontiers in Nutrition, 2023 Substantial attention has been paid to the various effects of metformin on liver diseases; the liver is the targeted organ where metformin exerts its antihyperglycemic properties.
Gaoyi Ruan +5 more
doaj +1 more source
STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection.
PLoS Pathogens, 2021 Macrophages metabolic reprogramming in response to microbial insults is a major determinant of pathogen growth or containment. Here, we reveal a distinct mechanism by which stimulator of interferon genes (STING), a cytosolic sensor that regulates innate ...
Marco Tulio R Gomes +8 more
doaj +1 more source
Stem Cells International, 2020 Most mesenchymal stem cells reside in a niche of low oxygen tension. Iron-chelating agents such as CoCl2 and deferoxamine have been utilized to mimic hypoxia and promote cell growth. The purpose of the present study was to explore whether a supplement of
Huimin Mao +4 more
doaj +1 more source
Post-translational modulation of cell signalling through protein succinylation
Exploration of Targeted Anti-tumor Therapy, 2023 Cells need to adapt their activities to extra- and intracellular signalling cues. To translate a received extracellular signal, cells have specific receptors that transmit the signal to downstream proteins so that it can reach the nucleus to initiate or ...
Katharina F. Kubatzky +2 more
doaj +1 more source
Neural Regeneration Research, 2023 Ischemic accumulation of succinate causes cerebral damage by excess production of reactive oxygen species. However, it is unknown whether ischemic accumulation of succinate affects neural stem cell proliferation. In this study, we established a rat model
Lin-Yan Huang +11 more
doaj +1 more source
Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release [PDF]
Journal of the American Society of Nephrology, 2009 Macula densa (MD) cells of the juxtaglomerular apparatus (JGA) are salt sensors and generate paracrine signals that control renal blood flow, glomerular filtration, and release of the prohypertensive hormone renin. We hypothesized that the recently identified succinate receptor GPR91 is present in MD cells and regulates renin release.
Sarah Laurin, Vargas +4 more
openaire +2 more sources
Expression and Iron-Dependent Regulation of Succinate Receptor GPR91 in Retinal Pigment Epithelium [PDF]
Investigative Opthalmology & Visual Science, 2011 GPR91, a succinate receptor, is expressed in retinal ganglion cells and induces vascular endothelial growth factor (VEGF) expression. RPE also expresses VEGF, but whether this cell expresses GPR91 is not known. Excessive iron is also proangiogenic, and hemochromatosis is associated with iron overload.
Jaya P, Gnana-Prakasam +7 more
openaire +2 more sources
The role of GPR91 in the Akita model of diabetic nephropathy (DN)
The FASEB Journal, 2012 The importance of local tissue metabolism, succinate accumulation and signaling via its receptor GPR91 in the activation of the intra‐renal renin‐angiotensin system (RAS) in DN has been established by our laboratory using the streptozotocin (STZ) model.
Haykanush Anush Gevorgyan +3 more
openaire +1 more source
Journal of Cellular Biochemistry, Volume 127, Issue 7, July 2026.ABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Meijing Li, Ryan J. Mailloux
wiley +1 more source