Results 21 to 30 of about 1,556 (139)

Identification of lead compounds for 99mTc and 18F GPR91 radiotracers [PDF]

Bioorganic & Medicinal Chemistry Letters, 2015
To develop the first radiotracer targeting GPR91, a cell membrane-bound receptor that modulates the cellular response to hyperglycemia and hypoxia, we designed and prepared a small series of compounds based on a published series of 1,8-naphthyridines with high affinity to GPR91.
Jeffrey, Klenc, Malgorzata, Lipowska, Andrew T, Taylor   +2 more
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Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle

Biomedicines, 2022
Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using
Wei-Chia Lee, Hong-Ren Yu, You-Lin Tain, Kay L.H. Wu, Yao-Chi Chuang, Julie Y.H. Chan   +5 more
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Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation [PDF]

Cell Communication and Signaling, 2014
Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in several tissues, including heart. Because some pathological conditions such as ischemia increase succinate blood levels, we investigated the role of ...
Aguiar, Carla J, Rocha-Franco, João A, Sousa, Pedro A, Santos, Anderson K, Ladeira, Marina, Rocha-Resende, Cibele, Ladeira, Luiz O, Resende, Rodrigo R, Botoni, Fernando A, Barrouin Melo, Marcos, Lima, Cristiano X, Carballido, José M, Cunha, Thiago M, Menezes, Gustavo B, Guatimosim, Silvia, Leite, M Fatima   +15 more
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GPR91 goes local [PDF]

Science-Business eXchange, 2008
GPR91 has emerged as a key target in multiple diseases that involve inflammation or angiogenesis. Novartis is already pursuing agonists and antagonists of the GPCR.
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Succinate Injection Rescues Vasculature and Improves Functional Recovery Following Acute Peripheral Ischemia in Rodents: A Multimodal Imaging Study

Cells, 2021
Succinate influences angiogenesis and neovascularization via a hormonelike effect on G-protein-coupled receptor 91 (GPR91). This effect has been demonstrated in the pathophysiology of diabetic retinopathy and rheumatoid arthritis.
Anaïs Moyon, Philippe Garrigue, Laure Balasse, Samantha Fernandez, Pauline Brige, Ahlem Bouhlel, Guillaume Hache, Françoise Dignat-George, David Taïeb, Benjamin Guillet   +9 more
doaj   +1 more source

Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle

American Journal of Physiology-Endocrinology and Metabolism, 2023
Macrophages but not skeletal muscle cells respond to extracellular succinate via SUCNR1/GPR91.
Abdelmoez, AM, Dmytriyeva, O, Zurke, Y-X, Trauelsen, M, Marica, AA, Savikj, M, Smith, JAB, Monaco, C, Schwartz, TW, Krook, A, Pillon, NJ   +10 more
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Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling [PDF]

Cell Death & Disease, 2018
AbstractAltered mitochondrial metabolism acts as an initial cause for cardiovascular diseases and metabolic intermediate succinate emerges as a mediator of mitochondrial dysfunction. This work aims to investigate whether or not extracellular succinate accumulation and its targeted G protein-coupled receptor-91 (GPR91) activation induce cardiac injury ...
Lu, Yi-Tong, Li, Lan-Zhu, Yang, Yi-Lin, Yin, Xiaojian, Liu, Qun, Zhang, Lei, Liu, Kang, Liu, Baolin, Li, Jia, Qi, Lian-Wen   +9 more
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GPR91 triggers paracrine signaling in the JGA

The FASEB Journal, 2007
GPR91, a kidney‐specific metabolic receptor is expressed in the juxtaglomerular apparatus (JGA) and its activation by succinate causes renin release. We aimed to identify the mechanism of GPR91 signaling. Glomerular endothelial cells (GENC), but not vascular smooth muscle (VSMC) or JG cells in culture expressed GPR91 confirmed by ...
Ildiko Toma, Jung Julie Kang, Eric Bansal, Arnold Sipos, Fiona McCulloch, Janos Peti‐Peterdi   +5 more
openaire   +1 more source

The Succinate Receptor SUCNR1 Resides at the Endoplasmic Reticulum and Relocates to the Plasma Membrane in Hypoxic Conditions

Cells, 2022
The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle metabolite succinate. GPCR signaling depends on the surrounding environment and intracellular localization through location bias.
Melanie Sanchez, David Hamel, Emmanuel Bajon, François Duhamel, Vikrant K. Bhosle, Tang Zhu, Jose Carlos Rivera, Rabah Dabouz, Mathieu Nadeau-Vallée, Nicholas Sitaras, David-Étienne Tremblay, Samy Omri, Tiffany Habelrih, Raphael Rouget, Xin Hou, Fernand Gobeil, Jean-Sébastien Joyal, Przemyslaw Sapieha, Grant Mitchell, Alfredo Ribeiro-Da-Silva, Mohammad Ali Mohammad Nezhady, Sylvain Chemtob   +21 more
doaj   +1 more source

High glucose and renin release: the role of succinate and GPR91 [PDF]

Kidney International, 2010
Diabetes mellitus is the most common and rapidly growing cause of end-stage renal disease. A classic hallmark of diabetes pathology is the activation of the intrarenal renin-angiotensin system (RAS), which may lead to hypertension and renal tissue injury, but the mechanism of RAS activation has been elusive.
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