Results 41 to 50 of about 1,817 (168)
STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection.
PLoS Pathogens, 2021 Macrophages metabolic reprogramming in response to microbial insults is a major determinant of pathogen growth or containment. Here, we reveal a distinct mechanism by which stimulator of interferon genes (STING), a cytosolic sensor that regulates innate ...
Marco Tulio R Gomes +8 more
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Stem Cells International, 2020 Most mesenchymal stem cells reside in a niche of low oxygen tension. Iron-chelating agents such as CoCl2 and deferoxamine have been utilized to mimic hypoxia and promote cell growth. The purpose of the present study was to explore whether a supplement of
Huimin Mao +4 more
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Post-translational modulation of cell signalling through protein succinylation
Exploration of Targeted Anti-tumor Therapy, 2023 Cells need to adapt their activities to extra- and intracellular signalling cues. To translate a received extracellular signal, cells have specific receptors that transmit the signal to downstream proteins so that it can reach the nucleus to initiate or ...
Katharina F. Kubatzky +2 more
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Neural Regeneration Research, 2023 Ischemic accumulation of succinate causes cerebral damage by excess production of reactive oxygen species. However, it is unknown whether ischemic accumulation of succinate affects neural stem cell proliferation. In this study, we established a rat model
Lin-Yan Huang +11 more
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Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release [PDF]
Journal of the American Society of Nephrology, 2009 Macula densa (MD) cells of the juxtaglomerular apparatus (JGA) are salt sensors and generate paracrine signals that control renal blood flow, glomerular filtration, and release of the prohypertensive hormone renin. We hypothesized that the recently identified succinate receptor GPR91 is present in MD cells and regulates renin release.
Sarah Laurin, Vargas +4 more
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The role of GPR91 in the Akita model of diabetic nephropathy (DN)
The FASEB Journal, 2012 The importance of local tissue metabolism, succinate accumulation and signaling via its receptor GPR91 in the activation of the intra‐renal renin‐angiotensin system (RAS) in DN has been established by our laboratory using the streptozotocin (STZ) model.
Haykanush Anush Gevorgyan +3 more
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Expression and Iron-Dependent Regulation of Succinate Receptor GPR91 in Retinal Pigment Epithelium [PDF]
Investigative Opthalmology & Visual Science, 2011 GPR91, a succinate receptor, is expressed in retinal ganglion cells and induces vascular endothelial growth factor (VEGF) expression. RPE also expresses VEGF, but whether this cell expresses GPR91 is not known. Excessive iron is also proangiogenic, and hemochromatosis is associated with iron overload.
Jaya P, Gnana-Prakasam +7 more
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Cancer-derived extracellular succinate: a driver of cancer metastasis
Journal of Biomedical Science, 2022 Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the mitochondrial matrix. It is a substrate of succinate dehydrogenase (SDH). Mutation of SDH subunits (SDHD and SDHB) in hereditary tumors such as paraganglioma or reduction
Cheng-Chin Kuo +2 more
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Data on the mechanisms underlying succinate-induced aortic contraction
Data in Brief, 2016 We describe the mechanisms underlying the vascular contraction induced by succinate. The data presented here are related to the article entitled “Pharmacological characterization of the mechanisms underlying the vascular effects of succinate” (L.N. Leite,
Natália A. Gonzaga +6 more
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, 2023 Pericytes are heterogeneous mural cells surrounding blood vessels that are critically involved in malignant progression. Here we identify a subset of vascular pericytes, defined by expression of PDGFR-β and GPR91, that promote tumorigenesis and tyrosine ...
Li, L (via Mendeley Data)
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