Results 61 to 70 of about 1,817 (168)
GPR91 deletion improves lithium‐induced nephrogenic diabetes insipidus
The FASEB Journal, 2012 Lithium (Li) is a commonly used treatment for bipolar disorders. However, the use of Li is complicated by its renal side effect causing nephrogenic diabetes insipidus (NDI). The mechanism by which Li causes NDI is incompletely understood but cyclooxygenase 2 (COX‐2) and prostaglandin E2 (PGE2) are primary players.
Lisa Lam +3 more
openaire +1 more source
MP62-09 DETRUSOR RELAXATION MEDIATED BY ACTIVATION OF THE SUCCINATE RECEPTOR GPR91. [PDF]
Journal of Urology, 2019 INTRODUCTION AND OBJECTIVES:The bladder urothelium and detrusor layer express the succinate receptor, GPR91.
Abubakr Mossa +3 more
openaire +1 more source
Expression and distribution of GPR91 in each group.
, 2016 Confocal immunofluorescent images of the rat heart showing that staining for GPR91 (red), DAPI (blue) and the cardiomyocyte marker actinin (green) co-localize (merged).
Di Yu (254015) +10 more
core +1 more source
Role of succinate/GPR91 pathway in the development of paclitaxelinduced peripheral neuropathic pain
, 2020 Paclitaxel é um quimioterápico amplamente empregado no tratamento de tumores sólidos, mas a neuropatia periférica é um efeito adverso dose-limitante e uma causa comum de interrupção do tratamento oncológico.
Gomes, Francisco Isaac Fernandes
core +1 more source
Biological Functions of Succinate (a Review of Foreign Experimental Studies)
Антибиотики и Химиотерапия, 2020 The published data on the modern concept of the biological role of succinate, an intermediate of the citric acid cycle are analysed in the review. Special interest to succinate is determined by investigations on the mitochondrial functions at different ...
V. V. Valeev +4 more
doaj
Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian +6 more
wiley +1 more source
GPR91 and GPR99 are expressed in RCGs and in axons and dendrites of retinal explants.
, 2018 (A-F) Expression of GPR91 and GPR99 proteins in retinal sections of E14/15 WT mouse embryos. Scale bars: 10 μm. (G-R): Expression of GPR91 and GPR99 in retinal explants, GCs, and neurites of E14/15 WT mouse embryos.
Alex Bouchard (5233874) +6 more
core +1 more source
International Journal of Microbiology, Volume 2026, Issue 1, 2026.Atherosclerosis is an inflammatory process affecting the blood vessels, mainly the arteries. It is an established cause of a range of vascular disorders. Under homeostatic conditions, gut microbiota interacts with the host to affect its physiology and perform functions such as maintaining the integrity of the gut–epithelial barrier and immune ...
Saarim Bari +5 more
wiley +1 more source
Maintenance of homeostasis in the aging hypothalamus: The central and peripheral roles of succinate
Frontiers in Endocrinology, 2015 Aging is the phenotype resulting from accumulation of genetic, cellular, and molecular damages. Many factors have been identified as either the cause or consequence of age-related decline in functions and repair mechanisms.
Thomas T. Chen +2 more
doaj +1 more source
Pediatric Discovery, Volume 3, Issue 4, December 2025.Succinate promotes macrophage to the M1 phenotype in the mouse mononuclear macrophage leukemia cells (Raw264.7 cells) and neonatal mice with NEC. Succinate activates the phosphatidylinositol 3‐kinase/protein kinase B (PI3K/AKT) pathway via succinate recepter 1 (SUCNR1), promoting M1 polarization of NEC intestinal macrophages.
Sha Liu +6 more
wiley +1 more source