Rôle des récepteurs aux protéines G (GPR55, GPR91 et GPR99) dans la croissance et le guidage axonal au cours du développement du système visuel [PDF]
, 2015 Lors de l’attribution du prix Nobel de chimie aux docteurs Robert Leftkowitz et Brian Kobika pour leurs travaux essentiels sur les récepteurs couplés à des protéines G (RCPGs), Sven Lindin, membre du comité Nobel, a affirmé que « jusqu'à la moitié » des ...
Cherif, Hosni
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Microbiota in Gut‐Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease
Comprehensive Physiology, Volume 15, Issue 3, June 2025.Influence of Dietary and Lifestyle Factors on Gut Microbiota and Cardiovascular Health. ABSTRACT Emerging evidence highlights the pivotal role of gut microbiota in regulating cardiovascular health and disease. The gut microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, interacts with its host through metabolites ...
Narendra Kondapalli +4 more
wiley +1 more source
Groundwater Flooding of Superficial Gravels in an Urbanized Catchment
Journal of Flood Risk Management, Volume 18, Issue 2, June 2025.ABSTRACT Groundwater behavior in superficial gravel aquifers is globally poorly understood, especially across urban regions where drinking water is sourced from elsewhere. This study focuses on one such region around Staines, SE UK, where local River Terrace Gravels form a thin (< 10 m) superficial aquifer.
Jonathan D. Paul +3 more
wiley +1 more source
The Classic Renovascular (Goldblatt) Hypertension (RVHT) is Mediated by Succinate/GPR91 Signaling
The FASEB Journal, 2012 The novel metabolic receptor GPR91 is key in the activation of the renin‐angiotensin system (RAS). The ligand of GPR91 is the TCA‐cycle intermediate succinate which quickly accumulates in hypoxic tissues. Succinate injection iv in mice causes acute elevations in blood pressure (BP) which is RAS and GPR91 dependent. In the 2‐ kidney, 1‐clip (2K1C) model
Anne DM Riquier-Brison +2 more
openaire +1 more source
Development of molecular tools for in vitro study of succinate receptor (GPR91) function
O succinato, intermediário do Ciclo de Krebs, está envolvido em diversas rotas metabólicas e é um importante componente para a regulação da homeostase energética.
Santos, Andressa Mayara dos
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Succinate and α-KG modulate GC morphology and increase neurite outgrowth via GPR91 and GPR99.
, 2018 (A) Photomicrographs of E14/15 GCs of retinal projections from WT, gpr91KO, gpr99KO, and double-KO mouse embryos, untreated and after treatment with GPR91 agonist (100 μM succinate) or GPR99 agonist (200 μM α-KG). (B) Analysis of GC surface area (N = 104–
Alex Bouchard (5233874) +6 more
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, 2016 When SUCNR1/GPR91 expressing macrophages are activated by inflammatory signals they change their metabolism and accumulate succinate. Here we show that during this activation macrophages release succinate into the extracellular milieu.
Dawson King, Janet +14 more
core
Glukose, suksinat og suksinatreseptoren GPR91 : Har rask reduksjon i glukose effekt på inflammasjonsprosessen, og hvilken rolle spiller GPR91 hos makrofager – har stimulering med suksinat noen effekt? [PDF]
, 2010 Background: The first of the two objectives in this study was based on a well demonstrated link between diabetes and chronic low-grade inflammation and the results from the ACCORD study and other studies investigating benefits and drawbacks in intensive ...
Hansen, Lise, Kvalbein, Magnhild Vaagen
core
GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice
Allergy, 2016 Succinate, in addition to its role as an intermediary of the citric acid cycle, acts as an alarmin, initiating and propagating danger signals resulting from tissue injury or inflammatory stimuli. The contribution of this immune sensing pathway to the development of allergic and inflammatory responses is unknown.Ear thickness of wild-type (wt) and ...
Rubić‐Schneider, T. +12 more
openaire +2 more sources
International Journal of Nanomedicine, 2019 Yongtao Gao,1 Haiyang Qian,2 Xue Tang,1 Xiling Du,3 Gang Wang,2 Hairong Zhang,2 Fei Ye,2 Te Liu41The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of ...
Gao Y +7 more
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