Results 71 to 80 of about 1,817 (168)
Succinate as a Regulator of Hepatic Stellate Cells in Liver Fibrosis
Frontiers in Endocrinology, 2018 The rapid increase of obesity rates worldwide is associated with chronic liver injury due to non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
Eun-Hee Cho
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
High succinate concentrations are implicated in rheumatoid arthritis (RA) and other inflammatory diseases through G protein–coupled receptor 91 (GPR91)–mediated signaling.
Wankang Zhang +10 more
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Cancer stem cells: Bridging microenvironmental interactions and clinical therapy
Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.Cancer stem cells (CSCs) drive tumor progression through their dynamic self‐renewal capacity, epigenetic plasticity, and drug resistance. These cells interact bi‐directionally with the tumor ecosystem to promote immunosuppressive reprogramming and metastatic spread.
Huiling Wang +3 more
wiley +1 more source
Les récepteurs GPR91 et GPR99 et leur implication dans le développement du système nerveux visuel [PDF]
, 2016 Les récepteurs couplés aux protéines G (RCPG) démontrent de plus en plus de capacités à activer des mécanismes jusqu’alors associés à des facteurs de transcription ou des molécules d’adhésion.
Bouchard, Alex
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Exploring the Influence of Metabolic Changes in Fibrotic Lung Diseases
Pulmonary Circulation, Volume 15, Issue 3, July 2025.ABSTRACT Fibrotic lung diseases are often characterized by chronic inflammation and the progressive destruction of the vasculature, parenchyma, and airways, leading to cellular metabolic changes. As a result, these changes activate several pathological pathways, contributing to the disease's progression and worsening.
Swati Kumari +5 more
wiley +1 more source
GPR91-PI3K/Akt signaling also exists in the human heart.
, 2016 A: Representative images of echocardiographic data from control, hypertrophic and non-hypertrophic patients. B: Representative images of HE-stained RA sections from control, hypertrophic and non-hypertrophic patients. C: GPR91 expression as determined by
Di Yu (254015) +10 more
core +1 more source
The FEBS Journal, Volume 292, Issue 14, Page 3736-3754, July 2025.RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Dayoung Yu +7 more
wiley +1 more source
Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning
The FASEB Journal, Volume 39, Issue 12, 30 June 2025.Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley +1 more source
The succinate-GPR91 axis is involved in the regulation of mast cell response
, 2013 [[abstract]]Background: Succinate, an intermediate of the TCA cycle in the mitochondria, has recently been shown to regulate various cellular functions through the G-protein-coupled, metabolic receptor, GPR91.
Chang, HW;Kawasaki, H;Tseng, HC;Hsu, SC;Yang, SJ;Huang, SK
core +1 more source