Results 91 to 100 of about 1,817 (168)
Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis
Communications BiologyAge-related cardiac fibrosis is a key driver of heart failure and hallmark of aging whose mechanisms remain incompletely understood. Here we show elevated succinate levels in aged mice and humans drive cardiac fibrosis by enhancing fibroblast activation ...
Ziwen Wang +17 more
doaj +1 more source
Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation [PDF]
, 2018 Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases, in part by modulating adaptive and innate immune responses. Since metabolism governs the phenotype and function of immune cells, the aim of
core +2 more sources
Introduction: Although atherosclerotic plaque progression is well studied, mechanisms governing diabetes-impaired atherosclerosis regression remain poorly understood.
Vinay Randhawa +4 more
core +1 more source
GPR91 and GPR99 agonists modulate GC morphology and increase axon growth via the ERK1/2 pathway.
, 2018 (A) Protein expression levels of P-ERK1/2, ERK1/2, and β-actin in primary neuron cultures incubated with one of the following: 100 μM succinate or 200 μM α-KG at 37 °C for 2, 5, and 15 min.
Alex Bouchard (5233874) +6 more
core +1 more source
, 2018 Western blot analysis of α-SMA, GPR91, AMPK phosphorylation, and total AMPK were detected using specific antibodies. Densitometric analysis was performed and data are presented as the mean values ± S.E. of three independent experiments.
Dae Hee Choi (773161) +4 more
core +1 more source
ANP gene expression and PI3K/Akt signaling in cardiac muscle cells in vitro.
, 2016 A: Immunofluorescent images of cardiomyocytes with fluorescein isothiocyanate (FITC)-conjugated siRNA GPR91. B, C: GPR91 gene and protein expression in the sham and siRNA-GPR91 groups (n = 3).
Di Yu (254015) +10 more
core +1 more source
, 2017 The role of metabolites produced from stem cell metabolism has been emerged as signaling molecules to regulate stem cell behaviors such as migration. The mitochondrial morphology is closely associated with the metabolic balance and stem cell function ...
Gee Euhn Choi +7 more
core +1 more source
Characterization of intestinal microbiota and metabolite-sensing GPCRs in Inflammatory Bowel Diseases: Relevance of GPR91 and GPR109A [PDF]
Inflammatory Bowel Diseases (IBD), which comprise Ulcerative Colitis (UC) and Crohn’s Disease (CD), are disorders of the gastrointestinal tract characterized by chronic inflammation and abnormal immune response.
Bauset Pastor, Cristina
core
PI3K/Akt signaling in each group.
, 2016 A: p-Akt/Akt expression from the western blot image of the sham, succinate, and succinate+wortmannin groups (n = 3); *P.05 compared to the sham group; #P.05 compared to the succinate group.
Di Yu (254015) +10 more
core +1 more source