Results 11 to 20 of about 1,817 (168)

Increased succinate receptor GPR91 involved in the pathogenesis of Mooren’s ulcer [PDF]

International Journal of Ophthalmology, 2018
AIM: To investigate the expression of succinate receptor GPR91 and its pathogenic roles in Mooren’s ulcer (MU). METHODS: Biopsy specimens were obtained from 7 patients with MU and 6 healthy donors.
Lin Li, Yan-Ling Dong, Ting Liu, Dan Luo, Chao Wei, Wei-Yun Shi   +5 more
doaj   +4 more sources

Inhibition of GPR91 Reduces Inflammatory Mediators Involved in Active Labor in Myometrium [PDF]

Mediators of Inflammation, 2020
Problem. Some G-protein-coupled receptors (GPCRs) are regulators of inflammation, yet the role of the GPRC, GPR91, is unknown in human myometrium during the processes of human labor and delivery, a major inflammatory event. Method of Study.
Ratana Lim, Martha Lappas
doaj   +7 more sources

Receptors of intermediates of carbohydrate metabolism, GPR91 and GPR99, mediate axon growth. [PDF]

PLoS Biology, 2018
During the development of the visual system, high levels of energy are expended propelling axons from the retina to the brain. However, the role of intermediates of carbohydrate metabolism in the development of the visual system has been overlooked. Here,
Hosni Cherif, François Duhamel, Bruno Cécyre, Alex Bouchard, Ariane Quintal, Sylvain Chemtob, Jean-François Bouchard   +6 more
doaj   +5 more sources

The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy.

PLoS ONE, 2016
BackgroundPulmonary arterial hypertension is characterized by increased pressure overload that leads to right ventricular hypertrophy (RVH). GPR91 is a formerly orphan G-protein-coupled receptor (GPCR) that has been characterized as a receptor for ...
Lei Yang, Di Yu, Ran Mo, Jiru Zhang, Hu Hua, Liang Hu, Yu Feng, Song Wang, Wei-Yan Zhang, Ning Yin, Xu-Ming Mo   +10 more
doaj   +5 more sources

G protein-coupled receptor 91 promotes the inflammatory response to Porphyromonas gingivalis in bone marrow-derived macrophages [PDF]

Heliyon
Macrophages are important for maintaining tissue homeostasis and defending against pathogens in periodontal tissues. However, these tissues are often vulnerable to damage due to local inflammatory responses within the host tissues.
Wenqi Su, Yujia Wang, Cancan Zu, Lang Lei, Houxuan Li   +4 more
doaj   +3 more sources

Succinate promotes pulmonary fibrosis through GPR91 and predicts death in idiopathic pulmonary fibrosis [PDF]

Scientific Reports
Idiopathic pulmonary fibrosis (IPF) is believed to be associated with a notable disruption of cellular energy metabolism. By detecting the changes of energy metabolites in the serum of patients with pulmonary fibrosis, we aimed to investigate the ...
Yijun He, Yuanyuan Han, Lijun Zou, Tingting Yao, Yan Zhang, Xin Lv, Mao Jiang, Lingzhi Long, Mengyu Li, Xiaoyun Cheng, Guoliang Jiang, Zhangzhe Peng, Lijian Tao, Jie Meng, Wei Xie   +14 more
doaj   +4 more sources

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation [PDF]

Cell Communication and Signaling, 2014
Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in several tissues, including heart. Because some pathological conditions such as ischemia increase succinate blood levels, we investigated the role of ...
Aguiar, Carla J, Rocha-Franco, João A, Sousa, Pedro A, Santos, Anderson K, Ladeira, Marina, Rocha-Resende, Cibele, Ladeira, Luiz O, Resende, Rodrigo R, Botoni, Fernando A, Barrouin Melo, Marcos, Lima, Cristiano X, Carballido, José M, Cunha, Thiago M, Menezes, Gustavo B, Guatimosim, Silvia, Leite, M Fatima   +15 more
openaire   +5 more sources

Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling [PDF]

Cell Death & Disease, 2018
AbstractAltered mitochondrial metabolism acts as an initial cause for cardiovascular diseases and metabolic intermediate succinate emerges as a mediator of mitochondrial dysfunction. This work aims to investigate whether or not extracellular succinate accumulation and its targeted G protein-coupled receptor-91 (GPR91) activation induce cardiac injury ...
Lu, Yi-Tong, Li, Lan-Zhu, Yang, Yi-Lin, Yin, Xiaojian, Liu, Qun, Zhang, Lei, Liu, Kang, Liu, Baolin, Li, Jia, Qi, Lian-Wen   +9 more
openaire   +3 more sources

High glucose and renin release: the role of succinate and GPR91 [PDF]

Kidney International, 2010
Diabetes mellitus is the most common and rapidly growing cause of end-stage renal disease. A classic hallmark of diabetes pathology is the activation of the intrarenal renin-angiotensin system (RAS), which may lead to hypertension and renal tissue injury, but the mechanism of RAS activation has been elusive.
Peti-Peterdi, János, János Peti-Peterdi   +1 more
openaire   +4 more sources

Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2023
Macrophages but not skeletal muscle cells respond to extracellular succinate via SUCNR1/GPR91.
Abdelmoez, AM, Dmytriyeva, O, Zurke, Y-X, Trauelsen, M, Marica, AA, Savikj, M, Smith, JAB, Monaco, C, Schwartz, TW, Krook, A, Pillon, NJ   +10 more
openaire   +4 more sources