Results 11 to 20 of about 1,556 (139)

Inhibition of GPR91 Reduces Inflammatory Mediators Involved in Active Labor in Myometrium [PDF]

Mediators of Inflammation, 2020
Problem. Some G-protein-coupled receptors (GPCRs) are regulators of inflammation, yet the role of the GPRC, GPR91, is unknown in human myometrium during the processes of human labor and delivery, a major inflammatory event. Method of Study.
Ratana Lim, Martha Lappas
doaj   +4 more sources

Receptors of intermediates of carbohydrate metabolism, GPR91 and GPR99, mediate axon growth. [PDF]

PLoS Biology, 2018
During the development of the visual system, high levels of energy are expended propelling axons from the retina to the brain. However, the role of intermediates of carbohydrate metabolism in the development of the visual system has been overlooked. Here,
Hosni Cherif, François Duhamel, Bruno Cécyre, Alex Bouchard, Ariane Quintal, Sylvain Chemtob, Jean-François Bouchard   +6 more
doaj   +4 more sources

Polysaccharides and Glycosides from Aralia echinocaulis Modulate Succinate Levels in the Gut to Target Intestinal Dendritic Cells via the Receptor GPR91 in the Treatment of Rheumatoid Arthritis [PDF]

Pharmaceuticals
Background: Aralia echinocaulis has therapeutic effects on rheumatoid arthritis (RA), with total polysaccharide and glycoside (TPGs) as main active components. RA pathogenesis involves gut microbiota dysbiosis and immune–metabolic crosstalk, but the role
Mengqiang Gao, Shanshan Ma, Yunzhi Li
doaj   +2 more sources

G protein-coupled receptor 91 activations suppressed mineralization in Porphyromonas gingivalis–infected osteoblasts [PDF]

Scientific Reports
Succinate receptor GPR91 is one of the G protein-coupled receptors (GPCRs) that interacts with various proteins to regulate diverse cellular functions such as cell morphology, apoptosis, and differentiation.
Wenqi Su, Dandan Zhang, Yujia Wang, Lang Lei, Houxuan Li   +4 more
doaj   +2 more sources

Metabolic rewiring through succinate–GPR91 signaling: a fresh perspective on HFpEF energetics [PDF]

Cardiovascular Diabetology
Succinate has recently emerged as a signaling metabolite that extends beyond its canonical role in the tricarboxylic acid (TCA) cycle to influence cellular adaptation and stress responses. In their study, Jia et al. identify the succinate-GPR91 axis as a
Marialucia Telesca, Valeria Masciovecchio, Sarah Costantino   +2 more
doaj   +2 more sources

The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy.

PLoS ONE, 2016
BackgroundPulmonary arterial hypertension is characterized by increased pressure overload that leads to right ventricular hypertrophy (RVH). GPR91 is a formerly orphan G-protein-coupled receptor (GPCR) that has been characterized as a receptor for ...
Lei Yang, Di Yu, Ran Mo, Jiru Zhang, Hu Hua, Liang Hu, Yu Feng, Song Wang, Wei-Yan Zhang, Ning Yin, Xu-Ming Mo   +10 more
doaj   +4 more sources

Tissue Immunometabolism in Autoimmunity [PDF]

European Journal of Immunology, Volume 56, Issue 1, January 2026.
The tissue metabolic environment in autoimmunity influences immune and nonimmune cells via fuelling cellular metabolism or through metabolic signalling. Intracellular metabolic sensors combine several environmental cues to control transcription, metabolism, and cell function.
Matteo Villa
wiley   +2 more sources

G protein-coupled receptor 91 promotes the inflammatory response to Porphyromonas gingivalis in bone marrow-derived macrophages [PDF]

Heliyon
Macrophages are important for maintaining tissue homeostasis and defending against pathogens in periodontal tissues. However, these tissues are often vulnerable to damage due to local inflammatory responses within the host tissues.
Wenqi Su, Yujia Wang, Cancan Zu, Lang Lei, Houxuan Li   +4 more
doaj   +2 more sources

Correction: Dallons et al. GPR91 Receptor Mediates Protection against Doxorubicin-Induced Cardiotoxicity without Altering Its Anticancer Efficacy. An In Vitro Study on H9C2 Cardiomyoblasts and Breast Cancer-Derived MCF-7 Cells. Cells 2020, 9, 2177 [PDF]

Cells
In the original publication [...]
Matthieu Dallons, Esma Alpan, Corentin Schepkens, Vanessa Tagliatti, Jean-Marie Colet   +4 more
doaj   +2 more sources

The role of the GPR91 ligand succinate in hematopoiesis [PDF]

Journal of Leukocyte Biology, 2009
AbstractRegulation of cellular metabolism by the citric acid cycle occurs in the mitochondria. However, the citric acid cycle intermediate succinate was shown recently to be a ligand for the G-protein-coupled receptor GPR91. Here, we describe a role for succinate and its receptor in the stimulation of hematopoietic progenitor cell (HPC) growth.
Yaron, Hakak, Karin, Lehmann-Bruinsma, Shirley, Phillips, Thuy, Le, Chen, Liaw, Daniel T, Connolly, Dominic P, Behan   +6 more
openaire   +2 more sources