Results 51 to 60 of about 1,568 (147)

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Influenza‐induced tuft cell expansion is associated with changes in ILC2 populations in the distal lungs of mice

Physiological Reports, Volume 14, Issue 13, July 2026.
Abstract Tuft cells act as sentinels that amplify type 2 inflammation primarily by activating type 2 innate lymphoid cells (ILC2s). Although normally absent from the distal lung, ectopic tuft cells form after severe lung injury including influenza infection in mice.
Maria Elena Gentile, Michael M. Maiden, Evelyn A. Martinez, Madeline Singh, Harshini Kelam, Nicolas P. Holcomb, Meryl Mendoza, Joanna Wong, Diana M. Abraham, Alena Klochkova, Sara Kass‐Gergi, Andrew E. Vaughan   +11 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions

Aging, 2013
Age-related macular degeneration (AMD) is a prominent cause of blindness in the Western world. To date, its molecular pathogenesis as well as the sequence of events leading to retinal degeneration remain largely ill-defined. While the invasion of choroidal neovessels in the retina is the primary mechanism that precipitates loss of sight, an earlier dry
Favret, S. Binet, F. Lapalme, E. Leboeuf, D. Carbadillo, J. Rubic, T. Picard, E. Mawambo, G. Tetreault, N. Joyal, J. S. Chemtob, S. Sennlaub, F. Sangiovanni, J. P. Guimond, M. Sapieha, P.   +15 more
openaire   +2 more sources

HDAC8 Promotes Liver Metastasis of Colorectal Cancer via Inhibition of IRF1 and Upregulation of SUCNR1

Oxidative Medicine and Cellular Longevity, 2022
Histone deacetylases (HDACs) are well‐characterized for their involvement in tumor progression. Herein, the current study set out to unravel the association of HDAC8 with colorectal cancer (CRC). Bioinformatics analyses were carried out to retrieve the expression patterns of HDAC8 in CRC and the underlying mechanism. Following expression determination,
Jierong Chen, Lixue Cao, Jianhong Ma, Caifeng Yue, Dandan Zhu, Ran An, Xiaoxiao Wang, Yunmiao Guo, Bing Gu   +8 more
openaire   +2 more sources

Mesenteric Adipose Tissue as a Modulator of Intestinal Inflammation: Mechanistic Insights and Model Systems in Crohn's Disease

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review explores how mesenteric adipose tissue, particularly creeping fat, contributes to intestinal inflammation through dysregulated adipokine signalling. We explore how metabolic stress alters immune‐adipose interactions and promotes disease progression.
Toka Omar, Carl Weidinger, Britta Siegmund   +2 more
wiley   +1 more source

Succinate as a New Actor in Pluripotency and Early Development?

Metabolites, 2022
Pluripotent cells have been stabilized from pre- and post-implantation blastocysts, representing respectively naïve and primed stages of embryonic stem cells (ESCs) with distinct epigenetic, metabolic and transcriptomic features.
Damien Detraux, Patricia Renard
doaj   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source

Management succinate release through SDHA by G protein-coupled receptor 91 signal, TRAP1, and SIRT3 regulation in lung cancer cells by NAR nanoparticles

Journal of Genetic Engineering and Biotechnology
Background: Cancer cells display oxidative metabolic dysregulation to fulfill their bioenergy requirements. Specifically, efforts were made to regulate the metabolite succinate and its negative effects as an inducer for neoplasm invasion and metastasis ...
Eman M. Ragab, Abeer A. Khamis, Tarek M. Mohamed, Doaa M. El Gamal   +3 more
doaj   +1 more source

Bioinformatic analysis identifies GPR91 as a potential key gene in brain injury after deep hypothermic low flow

Heliyon, 2023
Purpose: Explore the transcription change of brain ischemia and reperfusion injury after deep hypothermic low flow. Method: The data from PRJNA739516 and GSE104036 were obtained for the differentially expressed genes identification, functional enrichment
Song Puwei, Xu Jiali, Deqin Zhuoga, Wu Kede, Nishant Patel, An Jia, Qi Jirong, Mo Xuming   +7 more
doaj   +1 more source