Results 11 to 20 of about 1,568 (147)

Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1

Biomedicines, 2022
Angiogenesis is an essential process by which new blood vessels develop from existing ones. While adequate angiogenesis is a physiological process during, for example, tissue repair, insufficient and excessive angiogenesis stands on the pathological side.
Reham Atallah, Andrea Olschewski, Àkos Heinemann   +2 more
exaly   +5 more sources

Structural insights into ligand recognition and activation of the succinate receptor SUCNR1

Cell Reports
Summary: Succinate, a citric acid cycle intermediate, serves important functions in energy homeostasis and metabolic regulation. Extracellular succinate acts as a stress signal through succinate receptor (SUCNR1), a class A G protein-coupled receptor ...
Yezhou Liu, Richard Ye
exaly   +5 more sources

Impaired angiogenesis in gestational diabetes is linked to succinate/SUCNR1 axis dysregulation in late gestation

Journal of Physiology
Abstract figure legend Gestational Diabetes Mellitus (GDM) impacts on succinate metabolism and angiogenesis in the umbilical cord endothelium. (Left Panel) Succinate levels increase in both maternal and fetal circulation at delivery, with higher concentrations observed in GDM pregnancies compared to controls during late gestation.
Sergiy Klid Klid, Ursula Hiden, Elisa Weiss   +2 more
exaly   +4 more sources

Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis [PDF]

Communications Biology
Age-related cardiac fibrosis is a key driver of heart failure and hallmark of aging whose mechanisms remain incompletely understood. Here we show elevated succinate levels in aged mice and humans drive cardiac fibrosis by enhancing fibroblast activation ...
Ziwen Wang, Ziyuan Zhang, Zheng Ping, Shu Yang, Yaqi Li, Ting Jiang, Xin Zheng, Qi Zhang, Zhaochuan Liu, Xiaoli Zhang, Zhongyong Jiang, Deng Li, Haimei Sun, Bo Wu, Deshan Zhou, Xuebin Cao, Hanping Shi, Tingyi Sun   +17 more
doaj   +2 more sources

Compressive force-induced succinate production via metabolic reprogramming in periodontal ligament cells promotes orthodontic tooth movement [PDF]

Progress in Orthodontics
Objective This study aimed to elucidate metabolic alterations in gingival crevicular fluid (GCF) during orthodontic tooth movement (OTM) and investigate the role of the succinate-SUCNR1 axis in bone resorption and tooth movement.
Jiahong Shi, Lulu Wang, Liliang Shan, Meng Zhu, Yu Chen, Houxuan Li, Lang Lei   +6 more
doaj   +2 more sources

Succinate Promotes M1 Polarization of Intestinal Macrophages in Mice With Necrotizing Enterocolitis Through the PI3K/AKT Pathway [PDF]

Pediatric Discovery
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disorder that frequently affects premature infants, and its pathogenesis is closely related to macrophage polarization.
Sha Liu, Fang‐Ling Tang, Xiao‐Lin Yan, Xiao‐Chen Liu, Qing Ai, Lu‐Quan Li, Lei Bao   +6 more
doaj   +2 more sources

Bittersweet: how hyperglycemia exacerbates vitiligo progression through the succinate/SUCNR1 axis [PDF]

The Journal of Clinical Investigation
Vitiligo is a depigmenting disease marked by progressive T cell–driven destruction of melanocytes in the skin, hair, and mucosa. While vitiligo is known to be a T cell–mediated autoimmune disease, its triggers have remained poorly understood and ...
Kaitlyn G. O’Donnell, I. Caroline Le Poole   +1 more
doaj   +2 more sources

Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice [PDF]

International Journal of Oral Science
Aging involves the accumulation of various forms of molecular and cellular damage over time. Key features of aging, such as mitochondrial dysfunction, dysbiosis, and oxidative stress, are closely linked and largely driven by inflammation.
Fangxi Xu, Yuqi Guo, Scott C. Thomas, Anish Saxena, Samantha Hwang, Mridula Vardhan, Xin Li   +6 more
doaj   +2 more sources

Succinate in innate immunity: linking metabolic reprogramming to immune modulation [PDF]

Frontiers in Immunology
Succinate is an essential metabolite in the tricarboxylic acid (TCA) cycle. In mitochondria, succinate holds a unique position connecting the TCA cycle and the electron transport chain (ETC), thereby providing a shortcut path for adenosine triphosphate ...
Reham Atallah, Juergen Gindlhuber, Akos Heinemann   +2 more
doaj   +2 more sources

Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression [PDF]

Signal Transduction and Targeted Therapy
Colorectal cancer (CRC) is a prevalent malignant tumor, and its pathogenesis has not yet been fully elucidated. The tumor microenvironment (TME) and ferroptosis in cancer cells are key drivers of tumor progression and metastasis.
Wentao Li, Lin Liang, Siyi Liu, Jingqiong Tang, Shuangyan Ou, Zhijun Yuan, Yanhong Zhou, Xia Yuan   +7 more
doaj   +2 more sources