Results 11 to 20 of about 1,930 (160)

Structural insights into ligand recognition and activation of the succinate receptor SUCNR1

Cell Reports
Summary: Succinate, a citric acid cycle intermediate, serves important functions in energy homeostasis and metabolic regulation. Extracellular succinate acts as a stress signal through succinate receptor (SUCNR1), a class A G protein-coupled receptor ...
Yezhou Liu, Richard Ye
exaly   +6 more sources

Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development [PDF]

Cells, 2020
The pathogenesis of Crohn’s disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its receptor (SUCNR1) are involved in intestinal inflammation and fibrosis, we investigated their ...
Dolores Ortiz-Masiá, Laura Gisbert-Ferrándiz, Cristina Bauset, Sandra Coll, Céline Mamie, Michael Scharl, Juan V. Esplugues, Rafael Alós, Francisco Navarro, Jesús Cosín-Roger, María D. Barrachina, Sara Calatayud   +11 more
doaj   +11 more sources

Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1

Biomedicines, 2022
Angiogenesis is an essential process by which new blood vessels develop from existing ones. While adequate angiogenesis is a physiological process during, for example, tissue repair, insufficient and excessive angiogenesis stands on the pathological side.
Reham Atallah, Andrea Olschewski, Àkos Heinemann   +2 more
exaly   +5 more sources

SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes [PDF]

The Journal of Clinical Investigation
Pancreatic β cell dysfunction is a key feature of type 2 diabetes, and novel regulators of insulin secretion are desirable. Here, we report that succinate receptor 1 (SUCNR1) is expressed in β cells and is upregulated in hyperglycemic states in mice and ...
Joan Sabadell-Basallote, Brenno Astiarraga, Carlos Castaño, Miriam Ejarque, Maria Repollés-de-Dalmau, Ivan Quesada, Jordi Blanco, Catalina Núñez-Roa, M-Mar Rodríguez-Peña, Laia Martínez, Dario F. De Jesus, Laura Marroquí, Ramon Bosch, Eduard Montanya, Francesc X. Sureda, Andrea Tura, Andrea Mari, Rohit N. Kulkarni, Joan Vendrell, Sonia Fernández-Veledo   +19 more
doaj   +7 more sources

Hyperglycemia aggravates vitiligo through succinate/SUCNR1-mediated T cell activation [PDF]

The Journal of Clinical Investigation
Vitiligo is an autoimmune skin disease characterized by depigmentation, mainly due to CD8+ T cell–mediated destruction of melanocytes. Hyperglycemia exacerbates autoimmune responses and is associated with vitiligo; however, the underlying immunometabolic
Pan Kang, Yuqian Chang, Tingting Wang, Xiuli Yi, Yinghan Wang, Pengran Du, Jiaxi Chen, Baizhang Li, Shuli Li, Zhongjun Shao, Jianru Chen, Chunying Li   +11 more
doaj   +3 more sources

Impaired angiogenesis in gestational diabetes is linked to succinate/SUCNR1 axis dysregulation in late gestation

Journal of Physiology
Abstract figure legend Gestational Diabetes Mellitus (GDM) impacts on succinate metabolism and angiogenesis in the umbilical cord endothelium. (Left Panel) Succinate levels increase in both maternal and fetal circulation at delivery, with higher concentrations observed in GDM pregnancies compared to controls during late gestation.
Sergiy Klid Klid, Ursula Hiden, Elisa Weiss   +2 more
exaly   +4 more sources

DOP87 SUCNR1 a novel key protagonist in fistula development [PDF]

Journal of Crohn's and Colitis, 2020
Background Intestinal fistula is a common complication in CD patients whose aetiology is still not well-characterised. It is associated with an exacerbated inflammation and epithelial-to-mesenchymal transition (EMT), a process which ...
Bauset, C, Ortiz-Masia, D, Mamie, C, Cosín-Roger, J, Gisbert-Ferrandiz, L, Calatayud, S, Coll, S, Scharl, M, Barrachina, M D   +8 more
core   +3 more sources

Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2023
Succinate is released by skeletal muscle during exercise and activates SUCNR1/GPR91. Signaling of SUCNR1 is involved in metabolite-sensing paracrine communication in skeletal muscle during exercise.
Pillon, Nicolas J, Abdelmoez, Ahmed M, Smith, Jonathon AB, Marica, Alesandra A, Schwartz, Thue W., Krook, Anna, Schwartz, Thue W, Marica, Alesandra A., Dmytriyeva, Oksana, Zurke, Yasemin Xiomara, Abdelmoez, Ahmed M., Zurke, Yasemin-Xiomara, Monaco, Claudia, Savikj, Mladen, Pillon, Nicolas J., Trauelsen, Mette, Smith, Jonathon A.B.   +16 more
core   +4 more sources

SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes. [PDF]

Sci Adv
Succinate, a mitochondrial metabolite, also functions as an extracellular signal through its receptor succinate receptor 1 (SUCNR1), coordinating responses to nutrient availability. The physiological role of SUCNR1 within hepatocytes, however, is unclear.
Marsal-Beltran A, Salmerón-Pelado L, Ribas-Latre A, Repollés-de-Dalmau M, Rodríguez-Peña MM, Núñez-Roa C, Badia J, Madeira A, Novoa E, Beltrà M, Plata-Gómez AB, Capellades J, Escolà-Gil JC, Zorzano A, Yanes Ó, Efeyan A, Nogueiras R, Gracia-Sancho J, Vendrell J, Ceperuelo-Mallafré V, Fernández-Veledo S.   +20 more
europepmc   +3 more sources

Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment [PDF]

Cancers, 2022
The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate.
Mahmood Yaseen Hachim, Kandasamy, Richard Kumaran, Hachim, Mahmood Yaseen, Richard K. Kandasamy, Kandasamy, Richard K., Najm, Rania, Rania Najm   +6 more
core   +3 more sources