Results 21 to 30 of about 162,568 (118)

Experimental substantiation of permeabilized hepatocytes model for investigation of mitochondria in situ respiration [PDF]

The Ukrainian Biochemical Journal, 2015
To verify experimentally the model of permeabilized hepatocytes, the degree of cell permeability was assessed using trypan blue and polarographycally determined cell respiration rate upon succinate (0.35 mM) and α-ketoglutarate (1 mM) oxidation ...
V. M. Merlavsky, B. O. Manko, O. V. Ikkert, V. V. Manko   +3 more
doaj   +1 more source

Visualization and Quantification of Genetically Adapted Microbial Cells During Preculture

Frontiers in Microbiology, 2021
As culture history is known to affect the length of the lag phase and microbial cell growth, precultures are often grown in the same medium as the main culture for physiological adaptation and to reduce a prolonged lag time in some microbial cells.
Hyun Ju Kim, Haeyoung Jeong, Sang Jun Lee   +2 more
doaj   +1 more source

Immunometabolites Drive Bacterial Adaptation to the Airway

Frontiers in Immunology, 2021
Pseudomonas aeruginosa and Staphylococcus aureus are both opportunistic pathogens that are frequently associated with chronic lung infections. While bacterial virulence determinants are critical in initiating infection, the metabolic flexibility of these
Kira L. Tomlinson, Alice S. Prince, Tania Wong Fok Lung   +2 more
doaj   +1 more source

The influence of succinate-containing drugs on physical performance and recovery after exercise

Фармакокинетика и Фармакодинамика, 2019
An assessment of the influence of 2-ethyl-6-methyl-3-hydroxypyridine succinate (Mexidol) on the physical performance of small laboratory animals and recovery after exercise was made.
S. V. Radko, A. D. Dulepov
doaj   +1 more source

Acute Succinate Administration Increases Oxidative Phosphorylation and Skeletal Muscle Explosive Strength via SUCNR1

Frontiers in Veterinary Science, 2022
Endurance training and explosive strength training, with different contraction protein and energy metabolism adaptation in skeletal muscle, are both beneficial for physical function and quality of life.
Guli Xu, Yexian Yuan, Pei Luo, Jinping Yang, Jingjing Zhou, Canjun Zhu, Qingyan Jiang, Gang Shu   +7 more
doaj   +1 more source

Pulmonary Pathogens Adapt to Immune Signaling Metabolites in the Airway

Frontiers in Immunology, 2020
A limited number of pulmonary pathogens are able to evade normal mucosal defenses to establish acute infection and then adapt to cause chronic pneumonias.
Sebastián A. Riquelme, Tania Wong Fok Lung, Alice Prince   +2 more
doaj   +1 more source

Lactobacillus salivarius Promotion of Intestinal Stem Cell Activity in Hens Is Associated with Succinate-Induced Mitochondrial Energy Metabolism

mSystems, 2022
Currently, the regulation of Lactobacillus on intestinal stem cells (ISCs) attracts broad attention, but their active ingredients and the underlying mechanism are worthy of further study.
Zhou Zhou, Lingzi Yu, Jiajia Cao, Jiaming Yu, Zhibo Lin, Yi Hong, Sibo Jiang, Cong Chen, Yuling Mi, Caiqiao Zhang, Jian Li   +10 more
doaj   +1 more source

G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice

Cells, 2023
The TCA cycle intermediate metabolite ‘succinate’ has been proposed as an inflammatory mediator, influencing autoimmunity and allergic reactions, through ligation to its sensing receptor SUCNR1/GPR91.
Silke Griepke, Mette Trauelsen, Michelle D. Nilsson, Jakob Hansen, Lasse B. Steffensen, Thue W. Schwartz, Daniel F. J. Ketelhuth   +6 more
doaj   +1 more source

Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents

Journal of Pharmacy and Bioallied Sciences, 2018
Objective: Aim of the present work was to study the antioxidant properties of lithium salts of Krebs cycle substrates and their influence on immune cells. Lithium is a well-known and widely used mood stabilizer.
Evgenii Plotnikov, Elena Korotkova, Olesya Voronova   +2 more
doaj   +1 more source

Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish

Frontiers in Nutrition, 2022
Succinate is widely used in the food and feed industry as an acidulant, flavoring additive, and antimicrobial agent. This study investigated the effects of dietary succinate on growth, energy budget, nutritional metabolism, protein succinylation, and gut
Qianwen Ding, Qianwen Ding, Chenyao Lu, Qiang Hao, Qingshuang Zhang, Yalin Yang, Rolf Erik Olsen, Einar Ringo, Chao Ran, Zhen Zhang, Zhigang Zhou   +10 more
doaj   +1 more source