Results 21 to 30 of about 193,960 (302)

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Cell Reports, 2021
Summary: Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate receptor SUCNR1. In the present study, we characterize and compare effects and signaling pathways
Mette Trauelsen, Thomas K. Hiron, Da Lin, Jacob E. Petersen, Billy Breton, Anna Sofie Husted, Siv A. Hjorth, Asuka Inoue, Thomas M. Frimurer, Michel Bouvier, Chris A. O’Callaghan, Thue W. Schwartz   +11 more
doaj   +1 more source

Crc Regulates Succinate-Mediated Repression of Mineral Phosphate Solubilization in Acinetobacter sp. SK2 by Modulating Membrane Glucose Dehydrogenase

Frontiers in Microbiology, 2021
The plant growth-promoting Acinetobacter sp. SK2 isolated from Vigna radiata rhizosphere was characterized for mineral phosphate solubilization (MPS).
Krishna Bharwad, Niharika Ghoghari, Shalini Rajkumar   +2 more
doaj   +1 more source

The succinated proteome [PDF]

Mass Spectrometry Reviews, 2013
AbstractThe post‐translational modifications (PTMs) of cysteine residues include oxidation, S‐glutathionylation, S‐nitrosylation, and succination, all of which modify protein function or turnover in response to a changing intracellular redox environment.
Merkley, Eric D., Metz, Thomas O., Smith, Richard D., Baynes, John W., Frizzell, Norma   +4 more
openaire   +3 more sources

Active Estrogen–Succinate Metabolism Promotes Heme Accumulation and Increases the Proliferative and Invasive Potential of Endometrial Cancer Cells

Biomolecules, 2023
Uterine endometrial cancer (UEC) is an estrogen-related tumor. Succinate and heme metabolism play important roles in the progression of multiple tumors.
Jia-Jing Lu, Xing Zhang, Ayitila Abudukeyoumu, Zhen-Zhen Lai, Ding-Yu Hou, Jiang-Nan Wu, Xiang Tao, Ming-Qing Li, Xiao-Yong Zhu, Feng Xie   +9 more
doaj   +1 more source

Bis(2-aminothiazolium) succinate succinic acid [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
In the title compound, 2C(3)H(5)N(2)S(+)·C(4)H(4)O(4) (2-)·C(4)H(6)O(4), the thia-zolium ring is almost planar, with the maximum deviation from planarity being 0.0056 (8) Å for the C atom carrying the amine substituent. The N atom of the 2-amino-thia-zole mol-ecule is protonated. Both the anion and the acid lie across inversion centres.
Hoong-Kun Fun, Jain John, Samuel Robinson Jebas, T. Balasubramanian   +3 more
openaire   +3 more sources

Therapeutically targeting essential metabolites to improve immunometabolism manipulation after liver transplantation for hepatocellular carcinoma

Frontiers in Immunology, 2023
Hepatocellular carcinoma (HCC) is the most prevalent primary liver malignancy worldwide and is associated with a poor prognosis. Sophisticated molecular mechanisms and biological characteristics need to be explored to gain a better understanding of HCC ...
Wenhui Zhang, Yu Zhao, Qiang He, Ren Lang   +3 more
doaj   +1 more source

Rebalancing mitochondrial dynamics restores succinate dehydrogenase activity and reduces succinate release in hepatocellular carcinoma. [PDF]

J Biomed Sci
Background Dysregulated mitochondrial dynamics in cancer cells perturbs mitochondrial function and metabolism and promotes cancer progression.
Wu JY, Chang TC, Chen MJ, Cho SH, Liou JY, Kuo CC, Wu KK.   +6 more
europepmc   +2 more sources

A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

eLife, 2023
Using embryonic stem cells (ESCs) in regenerative medicine or in disease modeling requires a complete understanding of these cells. Two main distinct developmental states of ESCs have been stabilized in vitro, a naïve pre-implantation stage and a primed ...
Damien Detraux, Marino Caruso, Louise Feller, Maude Fransolet, Sébastien Meurant, Julie Mathieu, Thierry Arnould, Patricia Renard   +7 more
doaj   +1 more source

Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages

Metabolites, 2020
Immunometabolism revealed the crucial role of cellular metabolism in controlling immune cell phenotype and functions. Macrophages, key immune cells that support progression of numerous inflammatory diseases, have been well described as undergoing vast ...
Karl J. Harber, Kyra E. de Goede, Sanne G. S. Verberk, Elisa Meinster, Helga E. de Vries, Michel van Weeghel, Menno P. J. de Winther, Jan Van den Bossche   +7 more
doaj   +1 more source

Poly(butylene-succinate)-based blends with enhanced oxygen permeability [PDF]

, 2022
Poly(butylene succinate) (PBS) is a biodegradable polymer produced from renewable raw materials and is widely used in the production of packaging materials.
Nina, Kantor-Malujdy, Miroslawa, El Fray, Sandra, Skowron, Beata, Michalkiewicz   +3 more
core   +1 more source