Results 11 to 20 of about 193,960 (302)

Succinate Receptors in the Kidney [PDF]

Journal of the American Society of Nephrology, 2011
The G protein-coupled succinate and α-ketoglutarate receptors are closely related to the family of P2Y purinoreceptors. Although the α-ketoglutarate receptor is almost exclusively expressed in the kidney, its function is unknown. In contrast, the succinate receptor, SUCRN1, is expressed in a variety of tissues, including blood cells, adipose tissue ...
Deen, P.M.T., Robben, J.H.
openaire   +5 more sources

Aminoguanidinium hydrogen succinate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
The title compound, CH(7)N(4) (+)·C(4)H(5)O(4) (-), is a molecular salt containing discrete amino-guanidinium and succinate ions. The amino-guanidinium cation is nearly planar, with a maximum deviation of 0.035 (1) Å. The dihedral angle between the amino-guanidinium cation and the succinate anion is 3.35 (6)°.
Murugavel, S., Kannan, P. S., Subbiah Pandi, A., Govindarajan, S., Selvakumar, R.   +4 more
openaire   +4 more sources

Effects of succinate supplementation on rumen fermentation, microbiota, and propionate-associated metabolism in vitro [PDF]

Frontiers in Microbiology
IntroductionSuccinate is an intermediate in the ruminal succinate-propionate pathway, but its direct effects as an exogenous additive on rumen fermentation, bacterial community structure, and energy-related metabolites remain insufficiently characterized.
Wenyi Ren, Xiangde Zhu, Yuchen Cheng, Xiaofeng Xu, Lili Zhang   +4 more
doaj   +2 more sources

Gut microbiota-induced elevation of succinate exacerbates diabetic myocardial ischemia/reperfusion injury by promoting macrophage polarization [PDF]

Frontiers in Immunology
IntroductionPatients with diabetes exhibit increased susceptibility to myocardial ischemia/reperfusion (IR) injury. Emerging evidence highlights gut microbiota-derived microbial metabolites as critical modulators of the gut–heart axis.
Yang Wu, Juan Dou, Min Liu, Song Peng, Wenyuan Li   +4 more
doaj   +2 more sources

Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention

Frontiers in Immunology
Succinate, traditionally viewed as a mere intermediate of the tricarboxylic acid (TCA) cycle, has emerged as a critical mediator in inflammation. Disruptions within the TCA cycle lead to an accumulation of succinate in the mitochondrial matrix.
Jianye Yan, Xiong Cai
exaly   +3 more sources

Succinate Regulates Exercise‐Induced Muscle Remodelling by Boosting Satellite Cell Differentiation Through Succinate Receptor 1

Journal of Cachexia, Sarcopenia and Muscle
Background Skeletal muscle remodelling can cause clinically important changes in muscle phenotypes. Satellite cells (SCs) myogenic potential underlies the maintenance of muscle plasticity. Accumulating evidence shows the importance of succinate in muscle
Yifan Shi, Da Zhou, Haoyang Wang, Longchang Huang, Xuejin Gao, Gulisudumu Maitiabula, Li Zhang, Xinying Wang   +7 more
doaj   +2 more sources

Stress Hyperglycemia Drives CD4⁺ T Cell PANoptosis and Postoperative Organ Injury via Monocyte-Derived Succinate. [PDF]

Adv Sci (Weinh)
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Zhao S, Miao X, Luo W, Liu T, Wang Y, Li J, Fu D, Shen W, Luo Y, Chen K, Dai R, Li H.   +11 more
europepmc   +2 more sources

Flexible Thermal Sensitivity of Mitochondrial Oxygen Consumption and Substrate Oxidation in Flying Insect Species

Frontiers in Physiology, 2022
Mitochondria have been suggested to be paramount for temperature adaptation in insects. Considering the large range of environments colonized by this taxon, we hypothesized that species surviving large temperature changes would be those with the most ...
Hichem A. Menail, Hichem A. Menail, Simon B. Cormier, Simon B. Cormier, Mariem Ben Youssef, Lisa Bjerregaard Jørgensen, Jess L. Vickruck, Pier Morin, Luc H. Boudreau, Luc H. Boudreau, Nicolas Pichaud, Nicolas Pichaud   +11 more
doaj   +1 more source

Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish

Frontiers in Molecular Biosciences, 2021
Development of immunity-based strategy to manage bacterial infection is urgently needed in aquaculture due to the widespread of antibiotic-resistant bacteria.
Dai-xiao Yang, Dai-xiao Yang, Dai-xiao Yang, Hao Yang, Hao Yang, Hao Yang, Yun-chao Cao, Yun-chao Cao, Yun-chao Cao, Ming Jiang, Ming Jiang, Ming Jiang, Jun Zheng, Bo Peng, Bo Peng, Bo Peng   +15 more
doaj   +1 more source

Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat

Antioxidants, 2021
Reflex increases in breathing in response to acute hypoxia are dependent on activation of the carotid body (CB)—A specialised peripheral chemoreceptor.
Agnieszka Swiderska, Andrew M. Coney, Abdulaziz A. Alzahrani, Hayyaf S. Aldossary, Nikolaos Batis, Clare J. Ray, Prem Kumar, Andrew P. Holmes   +7 more
doaj   +1 more source