Results 11 to 20 of about 162,568 (118)

Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention

Frontiers in Immunology
Succinate, traditionally viewed as a mere intermediate of the tricarboxylic acid (TCA) cycle, has emerged as a critical mediator in inflammation. Disruptions within the TCA cycle lead to an accumulation of succinate in the mitochondrial matrix.
Xiong Cai, Cai Xiong, Yini He
exaly   +3 more sources

Multi-Omics Unravels Metabolic Alterations in the Ileal Mucosa of Neonatal Piglets Receiving Total Parenteral Nutrition

Metabolites, 2023
Total parenteral nutrition (TPN) is life-saving therapy for the pediatric patients with intestinal failure (IF) who cannot tolerate enteral nutrition (EN).
Junkai Yan, Yuling Zhao, Lu Jiang, Ying Wang, Wei Cai   +4 more
doaj   +1 more source

Tetrahydrocurcumin Derivatives Enhanced the Anti-Inflammatory Activity of Curcumin: Synthesis, Biological Evaluation, and Structure–Activity Relationship Analysis

Molecules, 2023
Tetrahydrocurcumin, the most abundant curcumin transformation product in biological systems, can potentially be a new alternative therapeutic agent with improved anti-inflammatory activity and higher bioavailability than curcumin.
Yisett González, Randy Mojica-Flores, Dilan Moreno-Labrador, Marisín Pecchio, K. S. Jagannatha Rao, Maicol Ahumedo-Monterrosa, Patricia L. Fernández, Oleg V. Larionov, Johant Lakey-Beitia   +8 more
doaj   +1 more source

Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad

Biomedicines, 2022
Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism.
Paule Bénit, Judith Goncalves, Riyad El Khoury, Malgorzata Rak, Judith Favier, Anne-Paule Gimenez-Roqueplo, Pierre Rustin   +6 more
doaj   +1 more source

Spectrometric analysis of the compatibility of succinic acid with iodinol and metronidazole in the animal wound-healing liposomal gel

Аграрная наука Евро-Северо-Востока, 2023
The expediency of including succinic acid (succinate) in wound healing gels has been studied and scientifically substantiated by infrared spectrometry. For this purpose, the interaction of antiseptic components of wound healing gels – metronidazole and ...
V. V. Mosyagin, A. G. Belyaev
doaj   +1 more source

Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis

Frontiers in Immunology, 2022
Inflammation is an important driver of atherosclerosis. Succinate is a new extracellular inflammatory alarm released by activated macrophages. Succinate is sensed by succinate receptor 1 (Sucnr1) and then transferred to effector cells.
Jingwen Xu, Yabing Zheng, Yaqing Zhao, Yujiao Zhang, Huilin Li, An Zhang, Xuehan Wang, Weizong Wang, Yinglong Hou, Jiangrong Wang   +9 more
doaj   +1 more source

NADES Compounds Identified in Hypoxis hemerocallidea Corms during Dormancy

Plants, 2022
Soaking Hypoxis hemerocallidea corms in distilled water improved the propagation and development of cormlets, suggesting the potential leaching-out of inhibitory chemical compounds.
Motiki M. Mofokeng, Gerhard Prinsloo, Hintsa T. Araya, Stephen O. Amoo, Christian P. du Plooy, Phatu W. Mashela   +5 more
doaj   +1 more source

Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle

Biomedicines, 2022
Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using
Wei-Chia Lee, Hong-Ren Yu, You-Lin Tain, Kay L.H. Wu, Yao-Chi Chuang, Julie Y.H. Chan   +5 more
doaj   +1 more source

Pseudomonas aeruginosa Consumption of Airway Metabolites Promotes Lung Infection

Pathogens, 2021
Prevailing dogma indicates that the lung of cystic fibrosis (CF) individuals is infected by multiple pathogens due to the abundant accumulation of mucus, which traps most of inhaled organisms.
Sebastián A. Riquelme, Alice Prince
doaj   +1 more source

Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase

Metabolites, 2021
Itaconate is a small molecule metabolite that is endogenously produced by cis-aconitate decarboxylase-1 (ACOD1) in mammalian cells and influences numerous cellular processes.
Thekla Cordes, Christian M. Metallo
doaj   +1 more source