A cyanosulfidic origin of the Krebs cycle. [PDF]
Sci Adv, 2021 All four cellular subsystems can be provided under compatible prebiotic conditions.
Ritson DJ.
europepmc +5 more sources
Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis [PDF]
Angewandte Chemie - International Edition, 2022 Hydrogen (H2) is a geological source of reducing electrons that is thought to have powered the metabolism of the last universal common ancestor to all extant life, and that is still metabolized by various modern organisms.
Joseph Moran
exaly +3 more sources
Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle [PDF]
eLifeThe retina consumes massive amounts of energy, yet its metabolism and substrate exploitation remain poorly understood. Here, we used a murine explant model to manipulate retinal energy metabolism under entirely controlled conditions and utilised 1H-NMR ...
Yiyi Chen +8 more
doaj +3 more sources
Krebs Cycle Reborn in Macrophage Immunometabolism
Annual Review of Immunology, 2020 A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell activation. Multiple immune receptor types rewire metabolic pathways as a key part of how they promote effector functions.
Luke A J O'neill
exaly +4 more sources
Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity [PDF]
Cell Reports, 2018 Succinate accumulates during ischemia, and its oxidation at reperfusion drives injury. The mechanism of ischemic succinate accumulation is controversial and is proposed to involve reversal of mitochondrial complex II.
Jimmy Zhang +5 more
doaj +3 more sources
The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism [PDF]
Frontiers in Oncology, 2018 Alternative splicing is a pervasive mechanism that molds the transcriptome to meet cell and organism needs. However, how this layer of gene expression regulation is coordinated with other aspects of the cell metabolism is still largely undefined. Glucose
Giuseppe Biamonti +2 more
doaj +3 more sources
Engineering of Escherichia coli for Krebs cycle-dependent production of malic acid [PDF]
Microbial Cell Factories, 2018 Background Malate is a C4-dicarboxylic acid widely used as an acidulant in the food and beverage industry. Rational engineering has been performed in the past for the development of microbial strains capable of efficient production of this metabolite ...
Debora Trichez +8 more
doaj +3 more sources
Dystrophinopathy-associated dysfunction of Krebs cycle metabolism. [PDF]
Hum Mol Genet, 2019 Duchenne muscular dystrophy is a deadly muscle-wasting disorder caused by loss of dystrophin protein. Studies suggest that metabolic alterations are important to disease pathogenesis. Because muscle accounts for ~40% of body mass, we hypothesized that dystrophy-mediated metabolic changes would be measurable in biofluids and that a metabolomic analysis ...
Lindsay A +4 more
europepmc +5 more sources
GPR91: expanding the frontiers of Krebs cycle intermediates. [PDF]
Cell Commun Signal, 2016 Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are also present in the blood stream. Currently, there are several reports that indicate functional roles for Krebs intermediates out of its cycle ...
de Castro Fonseca M +4 more
europepmc +6 more sources
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis. [PDF]
Cell Metab, 2021 Mitochondria have an independent genome (mtDNA) and protein synthesis machinery that coordinately activate for mitochondrial generation. Here, we report that the Krebs cycle intermediate fumarate links metabolism to mitobiogenesis through binding to ...
Wang YP +8 more
europepmc +2 more sources