Results 31 to 40 of about 51,377 (282)

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

Nature Communications, 2023
Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of the mitochondrial Krebs cycle in immunity remains largely unknown, in particular at the organism level.
Eunah Kim, Andrea Annibal, Yujin Lee, Hae-Eun H. Park, Seokjin Ham, Dae-Eun Jeong, Younghun Kim, Sangsoon Park, Sujeong Kwon, Yoonji Jung, JiSoo Park, Sieun S. Kim, Adam Antebi, Seung-Jae V. Lee   +13 more
doaj   +1 more source

Enzyme expression in indica and japonica rice cultivars under saline stress - doi: 10.4025/actascibiolsci.v34i4.8535

Acta Scientiarum: Biological Sciences, 2012
The southern State of Rio Grande do Sul (RS) is the main rice producer in Brazil with a 60% participation of the national production and 86% participation of the region. Rice culture irrigation system is done by flooding, which leads to soil salinization,
Maria da Graça de Souza Lima, Nei Fernandes Lopes, Paulo Dejalma Zimmer, Geri Eduardo Meneghello, Cristina Rodrigues Mendes, Luciano do Amarante   +5 more
doaj   +1 more source

Queueing theory model of Krebs cycle

Bioinformatics, 2021
AbstractMotivationQueueing theory can be effective in simulating biochemical reactions taking place in living cells, and the article paves a step toward development of a comprehensive model of cell metabolism. Such a model could help to accelerate and reduce costs for developing and testing investigational drugs reducing number of laboratory animals ...
Sylwester Kloska, Krzysztof Palczynski, Tomasz Marciniak, Tomasz Talaska, Marissa Nitz, Beata J. Wysocki, Paul H. Davis, Tadeusz A. Wysocki   +7 more
openaire   +2 more sources

The metabolism of aged seeds. The involvement of the pentose phosphate pathway in respiration in germinating rye grains of various ages

Acta Societatis Botanicorum Poloniae, 2014
Winter rye grains from different harvest years (having distinctly different viabilities) were studied in terms of germination, total dehydrogenase activity and growth analysis.
Kazimierz Zalewski
doaj   +1 more source

Inhibition of Malate Dehydrogenase-2 Protects Renal Tubular Epithelial Cells from Anoxia-Reoxygenation-Induced Death or Senescence

Biomolecules, 2022
Ischemia-reperfusion injury is the leading cause of acute kidney injury. Reactive oxygen species (ROS) production causes cell death or senescence. In cultures of primary human renal tubular epithelial cells (RPTECs) subjected to anoxia-reoxygenation ...
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis   +5 more
doaj   +1 more source

A Broken Krebs Cycle in Macrophages [PDF]

Immunity, 2015
Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a systems approach for unbiased analysis of cellular metabolism that reveals key metabolites and metabolic pathways required for distinct macrophage polarization states.
openaire   +2 more sources

Development of the therapeutic regimen based on the synergistic activity of cyclophosphamide and double-stranded DNA preparation which results in complete cure of mice engrafted with Krebs-2 ascites

Вавиловский журнал генетики и селекции, 2016
Cumulative evidence obtained in this series of studies has guided the logic behind the development of a novel composite dsDNA-based preparation whose therapeutic application according to the specific regimen completely cures the mice engrafted with ...
E. A. Potter, E. V. Dolgova, A. S. Proskurina, Ya. R. Efremov, O. S. Taranov, V. P. Nikolin, N. A. Popova, T. D. Dubatolova, D. D. Petrova, E. I. Vereschagin, A. M. Minkevich, O. M. Andrushkevich, S. I. Baiborodin, V. A. Rogachev, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev   +17 more
doaj   +1 more source

Metabolic reprogramming of Salmonella infected macrophages and its modulation by iron availability and the mTOR pathway

Microbial Cell, 2019
Iron is an essential nutrient for immune cells and microbes, therefore the control of its homeostasis plays a decisive role for infections. Moreover, iron affects metabolic pathways by modulating the translational expression of the key tricarboxylic acid
Julia Telser, Chiara Volani, Richard Hilbe, Markus Seifert, Natascha Brigo, Giuseppe Paglia, Günter Weiss   +6 more
doaj   +1 more source

Tissue Expressions of Regulatory Enzymes of the Krebs Cycle in Low- and High-grade Gliomas

, 2023
AIM: To compare tissue levels of the regulatory enzymes related to the Krebs cycle between low, and high-grade supratentorial gliomas. MATERIAL and METHODS: Forty patients who underwent surgery for supratentorial gliomas (19 with low-grade and 21 with ...
INCE, Merve, ORHAN, Bagnu, INAL, Berrin Bercik, KEMERDERE, RAHŞAN, KACIRA, Tibet, TANRIVERDİ, TANER, SERIN, Huriye, TAHMAZOGLU, Burak, Akyol, Mehmet Edip   +8 more
core   +1 more source

Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy. [PDF]

Am J Hum Genet, 2017
MDH2 encodes mitochondrial malate dehydrogenase (MDH), which is essential for the conversion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle.
Ait-El-Mkadem S, Dayem-Quere M, Gusic M, Chaussenot A, Bannwarth S, François B, Genin EC, Fragaki K, Volker-Touw CLM, Vasnier C, Serre V, van Gassen KLI, Lespinasse F, Richter S, Eisenhofer G, Rouzier C, Mochel F, De Saint-Martin A, Abi Warde MT, de Sain-van der Velde MGM, Jans JJM, Amiel J, Avsec Z, Mertes C, Haack TB, Strom T, Meitinger T, Bonnen PE, Taylor RW, Gagneur J, van Hasselt PM, Rötig A, Delahodde A, Prokisch H, Fuchs SA, Paquis-Flucklinger V.   +35 more
europepmc   +3 more sources