Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM) [PDF]
Molecular Cancer, 2009 Background Metabolic perturbations arising from malignant transformation have not been systematically characterized in human lung cancers in situ. Stable isotope resolved metabolomic analysis (SIRM) enables functional analysis of gene dysregulations in ...
Higashi Richard M +6 more
doaj +3 more sources
Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents
Journal of Pharmacy and Bioallied Sciences, 2018 Objective: Aim of the present work was to study the antioxidant properties of lithium salts of Krebs cycle substrates and their influence on immune cells. Lithium is a well-known and widely used mood stabilizer.
Evgenii Plotnikov +2 more
doaj +2 more sources
Cell MetabolismThe reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect of the immune response. Metabolic intermediates accumulate as a result of metabolic adaptations and mediate functions outside of metabolism in the ...
E. Palsson-McDermott, L. O'Neill
exaly +2 more sources
Ketamine exerts a protective role in a cell-based model of major depressive disorder via the inhibition of apoptosis and inflammation and activation of the Krebs cycle [PDF]
Biomolecules & Biomedicine, 2020 Major depressive disorder (MDD) is one of the most common psychiatric disorders characterized by major depressive episodes. Although great efforts have been made to develop antidepressant drugs that target the monoaminergic system, these drugs are ...
Wenfei Zhang +3 more
doaj +2 more sources
Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer. [PDF]
Prostate, 2019 Alternol is a natural compound isolated from fermentation products of a mutant fungus. Our previous studies demonstrated that Alternol specifically kills cancer cells but spares benign cells.
Li C +12 more
europepmc +2 more sources
The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. [PDF]
Cell Rep, 2017 Neurotransmission is a tightly regulated Ca2+-dependent process. Upon Ca2+ influx, Synaptotagmin1 (Syt1) promotes fusion of synaptic vesicles (SVs) with the plasma membrane.
Ugur B +9 more
europepmc +2 more sources
Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice. [PDF]
Pediatr Res, 2018 BackgroundReverse electron transport (RET) driven by the oxidation of succinate has been proposed as the mechanism of accelerated production of reactive oxygen species (ROS) in post-ischemic mitochondria.
Sahni PV +7 more
europepmc +2 more sources
Krebs Cycle Moonlights in Caspase Regulation. [PDF]
Dev Cell, 2016 In this issue of Developmental Cell, Aram et al. (2016) identify a mechanism that uses a Krebs cycle protein to control local activation of a ubiquitin ligase complex at the mitochondrial outer membrane for temporally and spatially restricted caspase activation during Drosophila sperm differentiation.
Minis A, Steller H.
europepmc +4 more sources
Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia. [PDF]
PLoS One, 2018 The liver is a highly vascularized organ receiving a dual input of oxygenated blood from the hepatic artery and portal vein. The impact of decreased blood flow on glucose metabolism and how hepatocytes could adapt to this restrictive environment are ...
Chan TS +9 more
europepmc +2 more sources
Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy. [PDF]
Am J Hum Genet, 2017 MDH2 encodes mitochondrial malate dehydrogenase (MDH), which is essential for the conversion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle.
Ait-El-Mkadem S +35 more
europepmc +2 more sources