Robustness of the Krebs Cycle under Physiological Conditions and in Cancer: New Clues for Evaluating Metabolism-Modifying Drug Therapies [PDF]
Biomedicines, 2022 The Krebs cycle in cells that contain mitochondria is necessary for both energy production and anabolic processes. In given cell/condition, the Krebs cycle is dynamic but remains at a steady state.
Rafael Franco, Joan Serrano-Marín
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A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids. [PDF]
Nat Chem, 2020 Efforts to decipher the prebiotic roots of metabolic pathways have focused on recapitulating modern biological transformations, with metals typically serving in place of cofactors and enzymes.
Stubbs RT +3 more
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Plasma Krebs Cycle Intermediates in Nonalcoholic Fatty Liver Disease. [PDF]
J Clin Med, 2020 Nonalcoholic liver disease (NAFLD) is manifested with a wide spectrum of clinical symptoms and is closely associated with the metabolic syndrome, inflammation, and mitochondrial dysfunction. Although the mechanism of mitochondrial dysfunction in NAFLD is
Sandlers Y +5 more
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The Impact of Krebs Cycle Intermediates on the Endocrine System and Immune System: A Comparison
Endocrines, 2023 Introduction: The Krebs cycle is an important set of reactions that synthesize different molecules and substances that affect various organs. The objective of this paper was to compare the effects of Krebs cycle intermediates on the endocrine system and ...
Borros M. Arneth
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A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation. [PDF]
Front Immunol, 2018 Metabolism in immune cells is no longer thought of as merely a process for adenosine triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of metabolic pathways upon activation is also for the production of metabolites that can ...
Williams NC, O'Neill LAJ.
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Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice. [PDF]
Sci Rep, 2019 Exposure to ambient air particulate matter (PM2.5) is well established as a risk factor for cardiovascular and pulmonary disease. Both epidemiologic and controlled exposure studies in humans and animals have demonstrated an association between air ...
Reyes-Caballero H +11 more
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Metals promote sequences of the reverse Krebs cycle. [PDF]
Nat Ecol Evol, 2017 The reverse tricarboxylic acid (rTCA) cycle (also known as the reverse Krebs cycle) is a central anabolic biochemical pathway whose origins are proposed to trace back to geochemistry, long before the advent of enzymes, RNA or cells, and whose imprint ...
Muchowska KB +5 more
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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair. [PDF]
Nat Genet, 2018 The hereditary cancer syndromes hereditary leiomyomatosis and renal cell cancer (HLRCC) and succinate dehydrogenase–related hereditary paraganglioma and pheochromocytoma (SDH PGL/PCC) are linked to germline loss-of-function mutations in genes encoding ...
Sulkowski PL +14 more
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Queueing theory model of Krebs cycle
Bioinformatics, 2021 AbstractMotivationQueueing theory can be effective in simulating biochemical reactions taking place in living cells, and the article paves a step toward development of a comprehensive model of cell metabolism. Such a model could help to accelerate and reduce costs for developing and testing investigational drugs reducing number of laboratory animals ...
Sylwester Kloska +7 more
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Sulfate radicals enable a non-enzymatic Krebs cycle precursor. [PDF]
Nat Ecol Evol, 2017 The evolutionary origins of the Krebs cycle (tricarboxylic acid cycle) are not currently clear. Despite the existence of a simple non-enzymatic Krebs cycle catalyst being dismissed only a few years ago as ‘an appeal to magic’, citrate and other ...
Keller MA +3 more
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