Dystrophinopathy-associated dysfunction of Krebs cycle metabolism. [PDF]
Hum Mol Genet, 2019 Duchenne muscular dystrophy is a deadly muscle-wasting disorder caused by loss of dystrophin protein. Studies suggest that metabolic alterations are important to disease pathogenesis. Because muscle accounts for ~40% of body mass, we hypothesized that dystrophy-mediated metabolic changes would be measurable in biofluids and that a metabolomic analysis ...
Lindsay A +4 more
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Engineering of Escherichia coli for Krebs cycle-dependent production of malic acid [PDF]
Microbial Cell Factories, 2018 Background Malate is a C4-dicarboxylic acid widely used as an acidulant in the food and beverage industry. Rational engineering has been performed in the past for the development of microbial strains capable of efficient production of this metabolite ...
Debora Trichez +8 more
doaj +2 more sources
GPR91: expanding the frontiers of Krebs cycle intermediates. [PDF]
Cell Commun Signal, 2016 Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are also present in the blood stream. Currently, there are several reports that indicate functional roles for Krebs intermediates out of its cycle ...
de Castro Fonseca M +4 more
europepmc +5 more sources
Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis [PDF]
Angewandte Chemie - International Edition, 2022 Joseph Moran
exaly +2 more sources
Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase. [PDF]
PLoS ONE, 2016 Methyltriphenylphosphonium (TPMP) salts have been widely used to measure the mitochondrial membrane potential and the triphenylphosphonium (TPP+) moiety has been attached to many bioactive compounds including antioxidants to target them into mitochondria
Moustafa Elkalaf +4 more
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Plasma Krebs Cycle Intermediates in Nonalcoholic Fatty Liver Disease. [PDF]
J Clin Med, 2020 Nonalcoholic liver disease (NAFLD) is manifested with a wide spectrum of clinical symptoms and is closely associated with the metabolic syndrome, inflammation, and mitochondrial dysfunction. Although the mechanism of mitochondrial dysfunction in NAFLD is
Sandlers Y +5 more
europepmc +2 more sources
Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria. [PDF]
Proc Natl Acad Sci U S ATo investigate the structure of the mycobacterial oxidative phosphorylation machinery, we prepared inverted membrane vesicles from Mycobacterium smegmatis, enriched for vesicles containing complexes of interest, and imaged the vesicles with electron ...
Di Trani JM +10 more
europepmc +2 more sources
Metabolites, 2021 Very long-chain acyl-CoA dehydrogenase deficiency (VLCADD, OMIM 609575) is associated with energy deficiency and mitochondrial dysfunction and may lead to rhabdomyolysis and cardiomyopathy.
Igor Radzikh +5 more
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Succinate and succinate dehydrogenase as a «foothold» in the Krebs cycle in critical conditions
Антибиотики и Химиотерапия, 2023 Purpose. Search and presentation of data from experimental and clinical studies reflecting the central role of succinate and succinate dehydrogenase in the regulation of adaptation mechanisms in critical conditions. Material and methods.
Yu. P. Orlov +9 more
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Instability and invariant measure in the mathematical model for oxidative phosphorylation and ATP synthesis in the cell [PDF]
The Ukrainian Biochemical Journal, 2023 The aim of this work was to analyze the process of oxidative phosphorylation and ATP synthesis in a cell using a mathematical model. The scenario of occurrence of the autoperiodic and chaotic modes depending on the ATP dissipation values was determined ...
V. I. Grytsay
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