Results 51 to 60 of about 1,970,147 (226)
Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function
Disease Models & Mechanisms, 2018 Isocitrate dehydrogenase (IDH) is an enzyme required for the production of α-ketoglutarate from isocitrate. IDH3 generates the NADH used in the mitochondria for ATP production, and is a tetramer made up of two α, one β and one γ subunit. Loss-of-function
Amy S. Findlay +12 more
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Advanced Science, EarlyView.A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury +18 more
wiley +1 more source
Metabolism of Plasmodium berghei. I. Krebs cycle
, 1968 The free parasites of Plasmodium berghei, obtained from infected cells of rats using an antiserum method, were investigated to study the operation of Krebs cycle. P.
Nagarajan, K
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Advanced Science, EarlyView.As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens +11 more
wiley +1 more source
Discovery of a second citric acid cycle complex
Heliyon, 2023 Together, Nobel Prize honoured work, mathematics, physics and the laws of nature have drawn a concept of clockwise cycling carboxylic acids in Krebs’ Citric Acid Cycle. A Citric Acid Cycle complex is defined by specific substrate, product and regulation.
Dirk Roosterman, Graeme Stuart Cottrell
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A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior
Advanced Science, EarlyView.Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li +12 more
wiley +1 more source
Citric Acid Production of Yeasts: An Overview
The EuroBiotech Journal, 2021 Citric acid, an intermediate product of the Krebs cycle, has a wide usage area in the food industry since it has some functions such as acidulant, flavouring agent, preservative and antioxidant. Although molds are the most commonly used microorganisms in
Börekçi Bilge Sayın +2 more
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“Reversed” Krebs Cycle Can Feed Tumors
, 2012 Certain cancer cells that have mutations preventing them from using the normal oxidative pathway of the Krebs cycle can ramp up the withdrawal of various intermediates from the Krebs cycle to churn out macromolecular precursors essential for rapid cell ...
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Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie
Angewandte Chemie, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis
Arthritis &Rheumatology, EarlyView.Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo +7 more
wiley +1 more source