Results 61 to 70 of about 51,377 (282)
Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma. [PDF]
PLoS ONE, 2013 Fumarate hydratase (FH)-deficient kidney cancer undergoes metabolic remodeling, with changes in mitochondrial respiration, glucose, and glutamine metabolism.
Youfeng Yang +11 more
doaj +1 more source
Network with two metabolic subsystems: pyruvate dehydrogenase and Krebs cycle.
, 2013 DMN formed by two subsystems arranged in series, which represent in a very simplified way the main interconnections between the pyruvate dehydrogenase complex (PDH) and Krebs cycle.
Antonio Vera-López (252354) +5 more
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Arterial Perivascular Space‐Mediated Solute Transport in the Mouse Brain
Exploration, EarlyView.The mechanisms underlying solute clearance from the brain parenchyma remain debated, with competing hypotheses involving bulk cerebrospinal fluid flow versus perivascular transport. Using multimodal in vivo imaging and computational modeling in mice, this study demonstrates that arterial pulsation drives bidirectional solute movement within the ...
Shiyong Li +9 more
wiley +1 more source
Nature Communications, 2019 The mechanisms associated with fatty acid synthase (FASN) upregulation during transformation are unclear. Here, the authors report that FASN promotes anaplerotic shift of the Krebs cycle in cancer cells expressing various oncogenes, and that its ...
Maria J. Bueno +12 more
doaj +1 more source
Gut Medicine, EarlyView.ABSTRACT Background Dopamine (DA) exerts complex concentration‐dependent effects on gastrointestinal motility. Although its inhibitory action through D2‐like receptors is well‐established, the mechanisms underlying its excitatory effects remain elusive.
Xiao‐Li Zhang +5 more
wiley +1 more source
Metabolomic Profiling Reveals PGPR-Driven Drought Tolerance in Contrasting Brassica juncea Genotypes
MetabolitesBackground: Drought stress is a major abiotic factor limiting Brassica juncea productivity, resulting in significant yield reductions. Plant Growth-Promoting Rhizobacteria (PGPR) have shown potential in enhancing drought tolerance; however, the ...
Asha Rani Sheoran +7 more
doaj +1 more source
Journal of Pharmacy Practice and Research, EarlyView.Abstract Background An increase in the ageing population across long‐term care facilities (LTCFs) has led to an increased risk of polypharmacy. Pharmacist‐led deprescribing (PLD) can reduce these risks but there are limitations to its widespread uptake.
Sefunmi Odetola +3 more
wiley +1 more source
Nature Communications, 2017 Divalent anion/Na+ symporter (DASS) transporters move intermediates of the Krebs cycle across the cell membrane. Here the authors present the substrate-bound structures of VcINDY, a DASS from Vibrio cholerae, which provide insights into the underlying ...
Rongxin Nie +4 more
doaj +1 more source
, 2023 Today, graph theory represents one of the most important modeling techniques in biology. One of the most important applications is in the study of metabolic networks. During metabolism, a set of sequential biochemical reactions takes place, which convert
Morenas Mateos, Carlos de Las +1 more
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