Results 61 to 70 of about 1,970,147 (226)
Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
Nature Communications, 2020 α-ketoglutarate is an intermediate of the Krebs Cycle that was recently reported to extend lifespan in C.Elegans. Here, the authors show that administration of α-ketoglutarate to mice reduces age-related bone loss, by ameliorating senescence of bone ...
Yuan Wang +15 more
doaj +1 more source
Anatomical Sciences Education, Volume 18, Issue 3, Page 289-300, March 2025.Abstract It is likely existing anatomical illustrations are often used as the basis for new illustrative works, given not all illustrators have access to human tissues, bodies, or prosections on which to base their illustrations. Potential issues arise with this practice in the realms of copyright infringement and plagiarism when authors are seeking to
Jon Cornwall +7 more
wiley +1 more source
Nature Communications, 2017 BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and ...
Adonia E. Papathanassiu +10 more
doaj +1 more source
Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma. [PDF]
PLoS ONE, 2013 Fumarate hydratase (FH)-deficient kidney cancer undergoes metabolic remodeling, with changes in mitochondrial respiration, glucose, and glutamine metabolism.
Youfeng Yang +11 more
doaj +1 more source
What drives animal responses to high severity fire? The role of functional traits
Biological Reviews, EarlyView.ABSTRACT Fire regimes are changing worldwide, with increases in the frequency, extent, and severity of fires posing growing risks to biodiversity. Fire severity – the degree of habitat alteration following fire – strongly influences both immediate survival and long‐term recovery of fauna.
Grace A. Vielleux +3 more
wiley +1 more source
Carrion ecology: concepts, interdisciplinary synthesis, and perspectives
Biological Reviews, EarlyView.ABSTRACT Carrion is a ubiquitous resource in both terrestrial and aquatic ecosystems, yet it has long been overlooked in ecological research. Over the past two decades, studies on carrion and the many organisms that exploit it have flourished, revealing not only wide‐ranging ecological functions but also significance far beyond ecology.
Marcos Moleón +38 more
wiley +1 more source
Nature Communications, 2019 The mechanisms associated with fatty acid synthase (FASN) upregulation during transformation are unclear. Here, the authors report that FASN promotes anaplerotic shift of the Krebs cycle in cancer cells expressing various oncogenes, and that its ...
Maria J. Bueno +12 more
doaj +1 more source
Gas chromatography-mass spectrometry based O-18 stable isotope labeling of Krebs cycle intermediates
, 2021 New technologies permit determining metabolomic profiles of human diseases by fingerprinting metabolites levels. However, to fully understand metabolomic phenotypes, metabolite levels and turnover rates are necessary to know. Krebs cycle is the major hub
Eylem, CEMİL CAN +9 more
core +1 more source
The Three Musketeers of Coevolutionary Circular Design
Business Strategy and the Environment, EarlyView.ABSTRACT The transition from a linear to a circular economy necessitates systemic changes in product design, data sharing, and material flows. Applying a coevolutionary framework, this study shows how these three dimensions interact dynamically in circular economy transitions.
Katia Picaud‐Bello, Hervé Legenvre
wiley +1 more source