Results 61 to 70 of about 3,604,308 (302)
Microbial Cell, 2019 Iron is an essential nutrient for immune cells and microbes, therefore the control of its homeostasis plays a decisive role for infections. Moreover, iron affects metabolic pathways by modulating the translational expression of the key tricarboxylic acid
Julia Telser +6 more
doaj +1 more source
Plants, 2023 Protein phosphatase 2A (PP2A) is a heterotrimeric conserved serine/threonine phosphatase complex that includes catalytic, scaffolding, and regulatory subunits.
Ahmed Elshobaky +3 more
doaj +1 more source
Nuclear spin physics in quantum dots: an optical investigation [PDF]
, 2012 The mesoscopic spin system formed by the 10E4-10E6 nuclear spins in a semiconductor quantum dot offers a unique setting for the study of many-body spin physics in the condensed matter.
Amand, Thierry +7 more
core +3 more sources
Mechanistic Information and Causal Continuity [PDF]
, 2010 Some biological processes (our examples are DNA expression and a reflex response in the leech) move from step to step in a way that cannot be completely understood solely in terms of causes and correlations.
Bogen, Jim, Machamer, Peter
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Вавиловский журнал генетики и селекции, 2016 Previously, we reported on the development of a therapeutic regimen allowing eradication of primary murine Krebs-2 ascites transplants. This protocol involved multiple injections of dsDNA preparations administered during the NER and HR phases of repair ...
E. A. Potter +14 more
doaj +1 more source
Transformations énergétiques en biochimie [PDF]
, 1961 I - Energie interne II - Entropie III - Energie libre IV - Energie libre et concentration V - Réactions exergoniques et réactions endergoniques VI L'adénosine triphosphate: ATP VII - La formation des liaisons phosphates à haute énergie de l'ATP a ...
Bové, Joseph M.
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function
Disease Models & Mechanisms, 2018 Isocitrate dehydrogenase (IDH) is an enzyme required for the production of α-ketoglutarate from isocitrate. IDH3 generates the NADH used in the mitochondria for ATP production, and is a tetramer made up of two α, one β and one γ subunit. Loss-of-function
Amy S. Findlay +12 more
doaj +1 more source
A novel alveolar Krebs cycle-triggered CO2 sensing mechanism regulates regional pulmonary ventilation. [PDF]
, 2011 Pulmonary perfusion disorders provoke atelectasis in order to minimize ventilation/perfusion mismatch. However, the underlying mechanisms remain unknown.
Alwin Goetz +7 more
core +1 more source