Results 71 to 80 of about 51,377 (282)

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Sulfate radicals enable a non-enzymatic Krebs cycle precursor

, 2020
The evolutionary origins of the tricarboxylic acid cycle (TCA), or Krebs cycle, are so far unclear. Despite a few years ago, the existence of a simple non-enzymatic Krebs-cycle catalyst has been dismissed 'as an appeal to magic', citrate and other ...
Domen Kampjut (9261443), Markus A Keller (9083573), Stuart A Harrison (9261446), Markus Ralser (46782)   +3 more
core  

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.

, 2018
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals.

core   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation

, 2003
The importance of a functional Krebs cycle for energy generation in the procyclic stage of Trypanosoma brucei was investigated under physiological conditions during logarithmic phase growth of a pleomorphic parasite strain.
Meer, P., van der, van der Meer, P., van Hellemond, J.J., Vogt, A., Boshart, M., Weelden, S.W.H., van, Saas, J., van Weelden, S.W.H., Tielens, A.G.M., Hellemond, J.J., van, Fast, B.   +10 more
core   +1 more source

Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas [PDF]

, 2017
Purpose: Mutations in Krebs cycle genes are frequently found in patients with pheochromocytomas/paragangliomas. Disruption of SDH, FH or MDH2 enzymatic activities lead to accumulation of specific metabolites, which give rise to epigenetic changes in the ...
Eisenhofer, Graeme, Richter, Susan, Pita, Guillermo, Lorena Maestre, Torres-Perez, Rafael, Emiliano Honrado, Robledo, Mercedes, Manel Esteller, Esteller, Manel, Remacha, Laura, Contreras Balsa, Laura, Iñaki Comino-Méndez, Satrustegui Gil Delgado, Jorgina, Mercedes Robledo, Maestre, Lorena, Alberto Cascón, Scherezade Jiménez, Honrado, Emiliano, Guillermo Pita, Jorgina Satrústegui, Galarreta, Antonio, Cascon, Alberto, Curras-Freixes, María, Rocío Letón, Graeme Eisenhofer, Comino-Mendez, Iñaki, Rafael Torres-Pérez, Leton, Rocío, Moran, Sebastian, Laura Remacha, Laura Contreras, Antonio Galarreta, Susan Richter, Sebastian Moran, Jimenez, Scherezade, María Currás-Freixes   +35 more
core   +1 more source

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source

Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion

Environmental Toxicology, EarlyView.
ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó, Luís P. Brás, Catarina M. D. Serra, Lara R. S. Fonseca, Sara Correia, Bruno J. Pereira, Ana P. Duarte, Henrique J. Cardoso, Cátia V. Vaz, Sílvia Socorro   +9 more
wiley   +1 more source

Altered regulation of metabolic pathways in human lung cancer discerned by ¹³C stable isotope-resolved metabolomics (SIRM)

Molecular Cancer, 2009
Background Metabolic perturbations arising from malignant transformation have not been systematically characterized in human lung cancers in situ. Stable isotope resolved metabolomic analysis (SIRM) enables functional analysis of gene dysregulations in ...
Higashi Richard M, Lane Andrew N, Fan Teresa WM, Farag Mohamed A, Gao Hong, Bousamra Michael, Miller Donald M   +6 more
doaj   +1 more source

The Krebs cycle

, 1988
The chemical process known as the Krebs cycle is examined in detail. Illustrates the cyclical metabolism of pyruvate and the subsequent generation of NADH inside the cell mitochondrion.Narrator, James Moriarty ; consultant, Bob ...

core