Results 81 to 90 of about 1,970,147 (226)

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Altered regulation of metabolic pathways in human lung cancer discerned by ¹³C stable isotope-resolved metabolomics (SIRM)

Molecular Cancer, 2009
Background Metabolic perturbations arising from malignant transformation have not been systematically characterized in human lung cancers in situ. Stable isotope resolved metabolomic analysis (SIRM) enables functional analysis of gene dysregulations in ...
Higashi Richard M, Lane Andrew N, Fan Teresa WM, Farag Mohamed A, Gao Hong, Bousamra Michael, Miller Donald M   +6 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Katherine Krebs Scrapbook, LU-387 [PDF]

, 1918
Katherine Hamilton Krebs was born in 1899 in Rockbridge, Virginia to Alexander McNutt and Eva Hamilton Krebs. In 1918, she enrolled in the State Normal School for Women in Farmville, Virginia, earning her diploma in 1920.
Krebs, Katherine, Longwood University
core   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Interview with Fred Krebs

, 2017
Fred Krebs discusses his life in education and the creation and history of JohnsonCounty Community ...

core  

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Fred Krebs as Benjamin Franklin

, 2017
Fred Krebs delivers a speech as Benjamin ...
Johnson County Community College Video Production
core  

Diabetes‐Induced Dysregulation of Purinergic Signaling in the Bladder Mucosa: Accelerated ATP Hydrolysis and Impaired Adenosine Uptake Promote Underactive Bladder Phenotype

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To explore molecular mechanisms underlying excessive extracellular adenosine (ADO) accumulation in the bladder lamina propria (LP) of mice with type 2 diabetes (T2D) induced by a high‐fat, high‐sucrose diet (HFHSD), conceivably leading to bladder underactivity.
Mahsa Borhani Peikani, Brian A. Perrino, Violeta N. Mutafova‐Yambolieva   +2 more
wiley   +1 more source

Hunting Strategies and Game Exploitation Organization in the Magdalenian: An Integrated Approach Based on Mortality Profiles and Stable Isotopes at Chaves Cave (Huesca, Spain)

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Understanding hunting strategies in Upper Paleolithic contexts remains challenging due to the complex relationships between prey behavior, environmental conditions, and human decision‐making. Addressing these dynamics requires integrating archeozoological, geospatial, and geochemical proxies capable of capturing demographic patterns, landscape
Alejandro Sierra, Marie Balasse, Luis Jiménez, Rafael Domingo, Lourdes Montes, Denis Fiorillo, Pilar Utrilla   +6 more
wiley   +1 more source