Results 101 to 110 of about 51,377 (282)

Excretion of Krebs cycle acids in relation to the cycle's function in avian kidney

, 1964
In the chicken, unilateral renal portal perfusion with certain intermediates of the Krebs cycle (notably sodium α-ketoglutarate, succinate, and fumarate) increased excretion of other cycle acids, particularly citrate and α-ketoglutarate.
Seraphim Woronkow, William D. Lotspeich
core   +1 more source

Network Structure and the Efficiency Gains from Mergers: Evidence from U.S. Freight Railroads

The RAND Journal of Economics, EarlyView.
ABSTRACT The trade‐off between market power and efficiency gains is central to antitrust analyses of mergers, but empirical evidence quantifying efficiencies remains limited. Using transaction‐level data from U.S. freight railroads (1985–2005), this article quantifies merger‐induced cost efficiencies, driven mainly by eliminating inter‐railroad ...
Yanyou Chen
wiley   +1 more source

Conversion of glutamate carbon to fatty acid carbon via citrate in rat epididymal fat pads

Journal of Lipid Research, 1964
The incorporation of the C14 of glutamate-2-C14 and glutamate-5-C14 into fatty acids by epididymal fat pads and liver slices suggests the operation of the following metabolic pathway: α-ketoglutarate → isocitrate → cis-aconitate → citrate → acetyl CoA ...
J. Madsen, S. Abraham, I.L. Chaikoff
doaj   +1 more source

Improvement of Mouse Spermatozoa Freezing at ‐80°C With Ascorbic Acid 2‐Glucoside at Thawing Phase

Andrology, EarlyView.
ABSTRACT Background Sperm cryopreservation is the most common method to maintain a great number of mutant mouse lines. However, the use of liquid nitrogen (LN2) for freezing presents considerable problems in terms of cost, safety, and accessibility. For this reason, the storage of semen samples at ‐80° in ultra‐freezers has been increasingly used in ...
Alessia Paradiso, Renata Paoletti, Simone Cassetti, Nicola Bernabò, Barbara Barboni, Marcello Raspa, Ferdinando Scavizzi   +6 more
wiley   +1 more source

The Succinated Proteome of FH-Mutant Tumours

Metabolites, 2014
Inherited mutations in the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity in HLRCC tumours causes accumulation of the Krebs cycle intermediate fumarate to high levels,
Ming Yang, Nicola Ternette, Huizhong Su, Raliat Dabiri, Benedikt M. Kessler, Julie Adam, Bin Tean Teh, Patrick J. Pollard   +7 more
doaj   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

The Evolution Of The Krebs Cycle: A Promising Subject For Meaningful Learning Of Biochemistry

, 2017
Evolution has been recognized as a key concept for biologists. To enhance comprehension and motivate biology undergraduates for the contents of central energetic metabolism, we addressed the Krebs cycle structure and functions in an evolutionary view. To
da Costa, Caetano; Galembeck, Eduardo
core   +2 more sources

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Changes in energetic metabolism of Biomphalaria glabrata (Mollusca, Planorbidae) in response to exogenous calcium

Brazilian Journal of Biology
Calcium is considered an essential element for the metabolism of aquatic snail Biomphalaria glabrata (Say, 1818), intermediate host of Schistosoma mansoni Sambon, 1907 in Brazil, and represents a limiting factor to its distribution and adaptation to the ...
L. D. Silva, V. C. S. Amaral, M. C. Vinaud, A. M. Castro, H. H. A. Rezende, D. B. Santos, C. C. Mello-Silva, J. C. B. Bezerra   +7 more
doaj   +1 more source

THE KREBS CYCLE IN GLOMERULI OF NORMAL RAT KIDNEY AND IN COMPENSATORY HYPERTROPHY

, 1967
The Krebs cycle in glomeruli of rat kidney was studied under normal conditions and in compensatory hypertrophy after unilateral nephrectomy. By using substrates of the cycle and measuring with the Cartesian diver technique the increase in oxygen uptake,
WIKTOR W. NOWINSKI, ANDRZEJ PIGOŃ
core   +1 more source