Results 121 to 130 of about 3,604,308 (302)

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Exploring the Impact of Polystyrene Microplastic Beads on Male Gonads of the Marine Mussel, Mytilus galloprovincialis

Environmental Toxicology, EarlyView.
ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese, Mariachiara Galati, Tiziana Cappello, Maria Maisano, Gennaro Lettieri, Carmela Marinaro, Marina Piscopo, Gianluca Fasciolo, Carlos Gravato, Gaetana Napolitano, Giulia Paolella, Annamaria Locascio, Rosaria Scudiero, Luigi Rosati   +13 more
wiley   +1 more source

Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion

Environmental Toxicology, EarlyView.
ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó, Luís P. Brás, Catarina M. D. Serra, Lara R. S. Fonseca, Sara Correia, Bruno J. Pereira, Ana P. Duarte, Henrique J. Cardoso, Cátia V. Vaz, Sílvia Socorro   +9 more
wiley   +1 more source

Conversion of glutamate carbon to fatty acid carbon via citrate in rat epididymal fat pads

Journal of Lipid Research, 1964
The incorporation of the C14 of glutamate-2-C14 and glutamate-5-C14 into fatty acids by epididymal fat pads and liver slices suggests the operation of the following metabolic pathway: α-ketoglutarate → isocitrate → cis-aconitate → citrate → acetyl CoA ...
J. Madsen, S. Abraham, I.L. Chaikoff
doaj   +1 more source

Comparative evaluation of noninvasive DNA sampling and line transect surveys for spring density estimation of black grouse and capercaillie

Wildlife Biology, EarlyView.
Reliable abundance estimates provide essential information in ecology, conservation and management of many wild grouse populations. In this 3‐year study, we comparatively evaluate the suitability of traditional line transect distance sampling of flushed birds versus a spatial capture–recapture survey with noninvasive DNA samples for individual ...
Henrik Brøseth, Oddmund Kleven, Kjetil Bevanger   +2 more
wiley   +1 more source

Illuminating mitochondrial metabolism with genetically encoded fluorescent indicators

Biosensors and Bioelectronics: X
Mitochondria are recognized as dynamic metabolic hubs that integrate bioenergetic, biosynthetic and signaling functions well beyond ATP production. Their matrix hosts the Krebs cycle, fatty acid β-oxidation, and key branches of amino-acid metabolism ...
C. Aburto, A. Pinilla, F. Carrera-Arenas, A. San Martín   +3 more
doaj   +1 more source

The Succinated Proteome of FH-Mutant Tumours

Metabolites, 2014
Inherited mutations in the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity in HLRCC tumours causes accumulation of the Krebs cycle intermediate fumarate to high levels,
Ming Yang, Nicola Ternette, Huizhong Su, Raliat Dabiri, Benedikt M. Kessler, Julie Adam, Bin Tean Teh, Patrick J. Pollard   +7 more
doaj   +1 more source

Nephropathia epidemica and Puumala virus occurrence in relation to bank vole (Clethrionomys glareolus) dynamics and environmental factors in northern Sweden [PDF]

, 2003
The objectives of the thesis were to investigate the spatio-temporal patterns of nephropathia epidemica (NE) in humans and Puumala virus (PUU) occurrence in relation to bank vole (Clethrionomys glareolus) dynamics and environmental factors in a region of
Olsson, Gert E.
core  

Phenological responses to climate change: advancing mating and calving in wild and semi‐captive Caspian red deer

Wildlife Biology, EarlyView.
Species respond to climate change through phenological and spatial shifts. Herbivorous mammals, in particular, are vulnerable due to their direct dependence on seasonal vegetation and the potential misalignment between their reproductive cycles and shifting food availability.
Farid Salmanpour, Zahra Shakoori, Frank van Langevelde, Bahram H. Kiabi, Roumina Sayahnia, Faraham Ahmadzadeh   +5 more
wiley   +1 more source

Micro‐habitat selection by boreal woodland caribou improves access to food

Wildlife Biology, EarlyView.
Bio‐logging sensors attached to radiotelemetry receivers have great potential to transform our understanding of the ecological, physiological, and energetic constraints that shape patterns of wildlife movement under field conditions. We used video camera collars to assess microhabitat selectivity by woodland caribou Rangifer tarandus in boreal forests ...
Ian D. Thompson, Philip A. Wiebe, Arthur R. Rodgers, Douglas Reid, James A. Baker, Brent R. Patterson, Eric McNeill, Romain Dejeante, John M. Fryxell   +8 more
wiley   +1 more source