Network Structure and the Efficiency Gains from Mergers: Evidence from U.S. Freight Railroads
The RAND Journal of Economics, EarlyView.ABSTRACT The trade‐off between market power and efficiency gains is central to antitrust analyses of mergers, but empirical evidence quantifying efficiencies remains limited. Using transaction‐level data from U.S. freight railroads (1985–2005), this article quantifies merger‐induced cost efficiencies, driven mainly by eliminating inter‐railroad ...
Yanyou Chen
wiley +1 more source
Improvement of Mouse Spermatozoa Freezing at ‐80°C With Ascorbic Acid 2‐Glucoside at Thawing Phase
Andrology, EarlyView.ABSTRACT Background Sperm cryopreservation is the most common method to maintain a great number of mutant mouse lines. However, the use of liquid nitrogen (LN2) for freezing presents considerable problems in terms of cost, safety, and accessibility. For this reason, the storage of semen samples at ‐80° in ultra‐freezers has been increasingly used in ...
Alessia Paradiso +6 more
wiley +1 more source
Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy. [PDF]
Oncotarget, 2022 Ueno D +17 more
europepmc +1 more source
Artificial Organs, EarlyView.The graphical abstract illustrates our rapid PI‐based spheroid viability assay: hepatocyte spheroids are formed and stained with AO/PI, imaged after a 15‐min incubation, and analyzed for PI brightness normalized to area. This metric correlates strongly with functional urea/DNA output, validating PI intensity as a fast, reliable indicator of spheroid ...
Michael G. Megaly +11 more
wiley +1 more source
Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset. [PDF]
PLoS Genet, 2021 Jeong J, Lee J, Kim JH, Lim C.
europepmc +1 more source
, 2000 This is the edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine,in London, on 9 February 1999. First published by the Wellcome Trust, 2000.
Christie, DA, Tansey, EM
core
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation. [PDF]
Sci Rep, 2022 Cheng G, Hardy M, You M, Kalyanaraman B.
europepmc +1 more source
The (un)importance of unemployment fluctuations for welfare [PDF]
This paper develops a real business cycle model with labor market search and matching frictions, which endogenously links both the cyclical fluctuations and the mean level of unemployment to the aggregate business cycle risk.
Keith Kuester, Philip Jung
core
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source