Results 141 to 150 of about 51,377 (282)

Leaky Sewers Hydraulically Disconnect from Groundwater: A Proof‐of‐Concept

Groundwater, EarlyView.
In this study, we newly demonstrate that leaky pipes can become hydraulically disconnected from the underlying groundwater—a phenomenon analogous to river–groundwater interactions. Through numerical modeling, we show that, as the groundwater table declines, the leakage flux from the pipe (in absolute terms) initially increases until a critical depth ...
Aaron Peche, Fritz Kalwa, Syed Mohaiminul Islam, Georg Houben, Thomas Graf, Sven Altfelder   +5 more
wiley   +1 more source

Glutaminase inhibitor CB-839 causes metabolic adjustments in colorectal cancer cells

Scientific Reports
Colorectal cancer (CRC) cells are ‘addicted’ to glutamine to satisfy energy and biosynthetic needs. Inhibiting glutamine metabolism enzymes, like glutaminase, is a potential cancer therapy strategy. Although the GLS inhibitor CB-839 is being evaluated in
Martina Spada, Cristina Piras, Vera Piera Leoni, Mattia Casula, Gabriella Simbula, Antonio Noto, Katia Lilliu, Karolina Krystyna Kopeć, Gabriele Serreli, Federica Murgia, Federica Etzi, Tinuccia Dettori, Luigi Atzori, Paola Caria   +13 more
doaj   +1 more source

Exploring neuropsychiatric manifestations of vitamin B complex deficiencies

Frontiers in Psychiatry
B complex vitamins, a group of eight water-soluble vitamins, play interconnected roles in maintaining nervous system health. Thiamine (B1), riboflavin (B2), and niacin (B3) are essential as co-enzymes in numerous metabolic reactions related to energy ...
Anamaria Han, Leandro Almeida, Nikhilesh Anand, Ihsan M. Salloum, Ihsan M. Salloum, Salim Kanaan, Salim Kanaan, Bharathi S. Gadad, Bharathi S. Gadad, João Paulo Lima Daher, João Paulo Lima Daher   +10 more
doaj   +1 more source

HLLKO mice show suppression of ketogenesis, Krebs cycle flux and gluconeogenesis.

, 2013
(a) Ketogenesis from octanoate is undetectable in HLLKO hepatocytes but is abundant in control hepatocytes. Hepatocytes (106/mL) were suspended in Krebs buffer with the indicated concentration of octanoate, then incubated for 30 min at 37°C. The reaction
Lisa Kratz (431238), Grant A. Mitchell (431240), Jiang Wei Wu (431234), Fernando Alvarez (127077), Shu Pei Wang (431235), Nicolas Gauthier (431233), Orval A. Mamer (431237), Lawrence Sweetman (339004), Pierre Allard (431236), Ann B. Moser (149637), François Lépine (45392), Yves Robitaille (431239)   +11 more
core   +1 more source

Standing on a common ground: a comparison of static stability approaches for pallet loading

International Transactions in Operational Research, EarlyView.
Abstract At the practical level, the static stability constraint is one of the most important constraints in practical pallet loading problems, such as air cargo palletizing. Approaches to modeling static stability, which range from base support and mechanical equilibrium calculations to physical simulation, differ in workflow, focus, and assumptions ...
Philipp G. Mazur, Frederick C. Gamer, António G. Ramos, Detlef Schoder   +3 more
wiley   +1 more source

Large‐scale meta‐analysis of infection risk with JAK–STAT inhibitors in 29,000 patients

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In this large meta‐analysis of 74 randomized controlled trials involving more than 29,000 patients, JAK–STAT inhibitors were associated with an increased risk of influenza, bronchitis and herpes infections, particularly herpes zoster, while an increased risk of serious opportunistic or fungal infections was not observed.
Máté Krebs, Lili Gulyás, Karen Krisztina Fazekas, Benedek Nagy, Mária Veronika Kolonics, Fanni Adél Meznerics, Norbert Kiss, András Bánvölgyi, Péter Hegyi, Péter Holló, Lajos Vince Kemény   +10 more
wiley   +1 more source

The IKU2/RLK7–MAPK–MINI3 signaling module controls endosperm cellularization timing to determine seed size in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The phosphorylation status of the WRKY transcription factor WRKY10/MINI3, controls the timing of endosperm cellularization in Arabiopsis, thus regulating final seed size, offering a molecular understanding that could inform future agricultural breeding strategies. ABSTRACT Seed size is a critical factor in determining crop yield.
Min Ni, Yuchen Qian, Tinggang Nong, Wangshu Mou, Niu Liu, La Yang, Dongdong Li, Huixia Shou, Juan Xu   +8 more
wiley   +1 more source

Functional morphology and biomechanics of the locomotor apparatus in the large Late Triassic carnivore Postosuchus kirkpatricki (Archosauria: Rauisuchidae)

Journal of Anatomy, EarlyView.
A three‐dimensional model is used to analyze the locomotor biomechanics of the large Late Triassic archosaurian reptile Postosuchus kirkpatricki. The study finds that it is more uncertain than previously concluded whether it was quadrupedal or bipedal, and plantigrade or digitigrade, but it clearly had locomotor specializations including large hindlimb
John R. Hutchinson, Emily Faughey, Matthew Humpage, Tristan Dupuis, Oliver E. Demuth, Romain Pintore, Francois Clarac   +6 more
wiley   +1 more source

A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids. [PDF]

Nat Chem, 2020
Stubbs RT, Yadav M, Krishnamurthy R, Springsteen G.   +3 more
europepmc   +1 more source

Impact of monomer contamination of isopropanol during post‐rinsing on the accuracy of dental models fabricated by vat photopolymerization

Journal of Prosthodontics, EarlyView.
Abstract Purpose The aim of this study was to investigate the impact of an increasing level of monomer contamination of isopropanol (isopropyl alcohol [IPA]) during post‐rinsing on the dimensional stability of test samples produced by vat photopolymerization.
Florian Flierl, Benedikt C. Spies, Severin Rothlauf, Kirstin Vach, Ralf J. Kohal, Jörg Lüchtenborg   +5 more
wiley   +1 more source