Results 161 to 170 of about 3,604,308 (302)
Glutaminase inhibitor CB-839 causes metabolic adjustments in colorectal cancer cells
Scientific ReportsColorectal cancer (CRC) cells are ‘addicted’ to glutamine to satisfy energy and biosynthetic needs. Inhibiting glutamine metabolism enzymes, like glutaminase, is a potential cancer therapy strategy. Although the GLS inhibitor CB-839 is being evaluated in
Martina Spada +13 more
doaj +1 more source
Exploring neuropsychiatric manifestations of vitamin B complex deficiencies
Frontiers in PsychiatryB complex vitamins, a group of eight water-soluble vitamins, play interconnected roles in maintaining nervous system health. Thiamine (B1), riboflavin (B2), and niacin (B3) are essential as co-enzymes in numerous metabolic reactions related to energy ...
Anamaria Han +10 more
doaj +1 more source
Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia
European Journal of Haematology, EarlyView.ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco +2 more
wiley +1 more source
Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle
Nature, 2019 K. Verschueren +10 more
semanticscholar +1 more source
Metabolic thermodynamics: pertinent reference state and energy potentials
The FEBS Journal, EarlyView.A recommendation and method to view the energy potentials of metabolites with reference to (green arrow) a biochemical precursor state (in green: water, Mg2+, phosphate, bicarbonate, ammonium, and sulfate, at pH = 7) rather than (the red arrow) the physical–chemical reference state (in grayish red) that is alien to biology, that is, O2, H2, N2 at 1 ...
Hans V. Westerhoff +21 more
wiley +1 more source
The Welfare Gains from Stabilization in a Stochastically Growing Economy with Idiosyncratic Shocks and Flexible Labor Supply [PDF]
Stochastic models with economy-wide shocks imply that the welfare costs of aggregate volatility are negligible. In reality idiosyncratic shocks are important, and empirical evidence suggests that their volatility is several times that of aggregate shocks.
Marcelo Bianconi
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The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
Fast & fuelious: the malate–aspartate shuttle in brown adipocyte lipid metabolism
The FEBS Journal, EarlyView.Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate–aspartate shuttle (MAS) supports norepinephrine‐
Lukas Blaas, Alexander Bartelt
wiley +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Trade Policy, Income Risk, and Welfare [PDF]
This paper studies empirically the relationship between trade policy and individual income risk faced by workers, and uses the estimates of this empirical analysis to evaluate the welfare effect of trade reform.
Pravin Krishna +2 more
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