Results 151 to 160 of about 51,377 (282)

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Do fawn‐footed mosaic‐tailed rats experience age‐related cognitive decline in novel object recognition?

Journal of Zoology, EarlyView.
We explored age‐related cognitive decline in captive fawn‐footed mosaic‐tailed rats (Melomys cervinipes) using a novel object recognition task. Contrary to expectations, recognition memory did not decline with age, but recognition memory was lower in intermediate‐aged rats compared to both older and younger individuals.
K. DiBenedetto, M. K. Rowell, T. L. Rymer   +2 more
wiley   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

Gene Editing of Nicotiana benthamiana Architecture for Space‐Efficient Production of Recombinant Proteins in Closed Environments

Plant Biotechnology Journal, EarlyView.
ABSTRACT Indoor vertical farming (VF) offers practical advantages for the cultivation of plant protein bio‐factories including plant uniformity, product consistency, water/nutrient recycling and production cycles on a year‐round basis. Much progress has been achieved toward the development of innovative systems for artificial lighting, automated ...
Béatrice Giroux, Kristina LeBreux, Louis Feyzeau, Marie‐Claire Goulet, Charles Goulet, Dominique Michaud   +5 more
wiley   +1 more source

A TAF10‐ERF109 Transcriptional Module Directs Flavonoid‐Based Stress Resilience and Yield Enhancement in Foxtail Millet and Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT To ensure sustainable agricultural production under escalating environmental constraints such as drought and salinity, innovative strategies are urgently needed. Here, we reveal in foxtail millet (Setaria italica) that transcription factors TAF10 and ERF109 form a functional complex which co‐activates the expression of key flavonoid ...
Meng Zhang, Kangwei Wang, Jiayin Fan, Yue Zheng, Qi Zhang, Haoyang Du, Shenghui Xiao, Jinguang Huang, Kang Yan, Shizhong Zhang, Qiang He, Guanqing Jia, Chengchao Zheng, Xianmin Diao, Guodong Yang, Changai Wu   +15 more
wiley   +1 more source

Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy [PDF]

MDH2 encodes mitochondrial malate dehydrogenase (MDH), which is essential for the conversion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle.
Richter S, Amiel J, Avsec Z, Gagneur J, Haack TB, Delahodde A, Fuchs SA, Rotig A, Prokisch H, De Saint-Martin A, van Hasselt PM, Serre V, Mochel F, Bonnen PE, Eisenhofer G, Francois B, Rouzier C, de Sain-van der Velde MGM, Meitinger T, Fragaki K, Mertes C, Jans JJM, Gusic M, Bannwarth S, van Gassen KLI, Genin EC, Strom T, Dayem-Quere M, Taylor RW, Paquis-Flucklinger V, Chaussenot A, Lespinasse F, Ait-El-Mkadem S, Vasnier C, Volker-Touw CLM, Warde MTA   +35 more
core  

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, EarlyView.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Unraveling Complex Impacts Pathways of the Ecodesign for Sustainable Products Regulation and Corporate Sustainability Due Diligence Directive in Global Textile Value Chains: A European Perspective

Regulation &Governance, EarlyView.
ABSTRACT Through the Ecodesign for Sustainable Products Regulation and the Corporate Sustainability Due Diligence Directive, the European Commission targets sustainable products and value chains to curb environmental and social problems. Based on a combination of a complex systems lens and the global value chain and global governance approaches, the ...
Emilia Stadler, Michelle Bonatti, Dagmar Mithöfer   +2 more
wiley   +1 more source

Influence of Rare Earth Elements on Prebiotic Reaction Networks Resembling the Biologically Relevant Krebs Cycle. [PDF]

Angew Chem Int Ed Engl
Gutenthaler-Tietze J, Heßler CG, Daumann LJ.   +2 more
europepmc   +1 more source