Results 1 to 10 of about 4,514 (109)

Dimethyl itaconate induces long-term innate immune responses and confers protection against infection

Cell Reports, 2023
Summary: Itaconate is an immunomodulatory metabolite produced by immune cells under microbial stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti-inflammatory responses.
Theologia Gkavogianni
exaly   +3 more sources

4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

Cell Reports, 2023
Summary: The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins.
Jiaqi Kang
exaly   +3 more sources

The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases

Redox Biology, 2022
Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key molecule that accumulates in cells when the Krebs cycle is disrupted.
Juan Wei, Fu Li, Xin Lv
exaly   +3 more sources

Unravelling the metabolism of itaconate and related branched C5-dicarboxylates for CO2-based production in Cupriavidus necator H16 [PDF]

Journal of Biological Engineering
Branched C5-dicarboxylates (C5-DCAs), such as itaconate, are high-value platform chemicals with diverse applications in the synthesis of bio-based polymers.
Erik K. R. Hanko, Naglis Malys
doaj   +2 more sources

Itaconate confers tolerance to late NLRP3 inflammasome activation

Cell Reports, 2021
Summary: Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated
Martina Kerndl, Denis A Mogilenko, Gaya K. Amarasinghe   +2 more
exaly   +3 more sources

Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2

EBioMedicine, 2020
Absract: Background: Identifying effective drugs to suppress vascular inflammation is a promising strategy to delay the progression of abdominal aortic aneurysm (AAA).
Yulin Liao, Wangjun Liao, Tong Xu
exaly   +3 more sources

Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages

Cell Reports
Summary: A wide variety of electrophilic derivatives of itaconate, the Kreb’s cycle-derived metabolite, are immunomodulatory, yet these derivatives have overlapping and sometimes contradictory activities.
Kenneth Roth, Frank Dorsey, Jesus A Gutierrez   +2 more
exaly   +3 more sources

The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI [PDF]

Frontiers in Immunology
BackgroundItaconate has received attention as a key immunometabolic mediator produced by activated macrophages, linking cellular metabolism to inflammatory responses.
Amanda Cuevas-Sierra, Andrea Higuera-Gómez, Andrea Higuera-Gómez, Begoña de Cuevillas, Gabriela Paula-Buestan, María Martínez-Urbistondo, Raquel Castejón, J. Antonio Vargas, José Moisés Laparra, José Moisés Laparra, J. Alfredo Martínez, J. Alfredo Martínez, J. Alfredo Martínez   +12 more
doaj   +2 more sources

Offense and defense: itaconate mediates bidirectional immune regulation of host-bacteria interaction [PDF]

Journal of Biomedical Science
Itaconate has garnered significant attention in recent years due to its immunomodulatory and antimicrobial functions. During inflammation and pathogenic infections, itaconate is formed through the decarboxylation of cis-aconitate in the mitochondrial ...
Zhaoyue Men, Zishen Lin, Zhe Wang, Peng Tan, Shuyang Yu, Xi Ma   +5 more
doaj   +2 more sources

Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense [PDF]

JCI Insight
Mycobacterium tuberculosis (Mtb) survives within multiple macrophage populations during infection, including alveolar macrophages (AMs) and recruited inflammatory macrophages.
Adam S. Krebs, Tomi Lazarov, Anthony T. Reynolds, Kimberly A. Dill-McFarland, Abigail Xie, James M. Bean, Muxue Du, Olivier Levy, John A. Buglino, Aaron Zhong, Anna-Lena Neehus, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova, Elouise E. Kroon, Marlo Möller, Thomas R. Hawn, Ting Zhou, Lydia W.S. Finley, Marc Antoine Jean Juste, Dan W. Fitzgerald, Frederic Geissmann, Michael S. Glickman   +21 more
doaj   +2 more sources