Results 21 to 30 of about 4,169 (171)

Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate

Metabolites, 2021
Itaconate is derived from the tricarboxylic acid (TCA) cycle intermediate cis-aconitate and links innate immunity and metabolism. Its synthesis is altered in inflammation-related disorders and it therefore has potential as clinical biomarker.
Moritz Winterhoff, Fangfang Chen, Nishika Sahini, Thomas Ebensen, Maike Kuhn, Volkhard Kaever, Heike Bähre, Frank Pessler   +7 more
doaj   +1 more source

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

Cell Reports Medicine, 2021
Summary: The eye is highly susceptible to inflammation-mediated tissue damage evoked during bacterial infection. However, mechanisms regulating inflammation to protect the eye remain elusive.
Sukhvinder Singh, Pawan Kumar Singh, Alokkumar Jha, Poonam Naik, Joveeta Joseph, Shailendra Giri, Ashok Kumar   +6 more
doaj   +1 more source

Itaconate Isomers in Bread

Antioxidants, 2022
The naturally occurring isomers itaconate, mesaconate and citraconate possess immunomodulatory, antioxidative and antimicrobial properties. However, it is not known whether they occur in commonly consumed human foods. Considering that they can arise as a result of heat conversion, we tested whether they occur in bread, representing a commonly consumed ...
Mona Gruenwald, Fangfang Chen, Heike Bähre, Frank Pessler   +3 more
openaire   +3 more sources

Itaconate Suppresses the Activation of Mitochondrial NLRP3 Inflammasome and Oxidative Stress in Allergic Airway Inflammation

Antioxidants, 2023
Itaconate has emerged as a novel anti-inflammatory and antioxidative endogenous metabolite, yet its role in allergic airway inflammation (AAI) and the underlying mechanism remains elusive.
Qiu-Meng Xie, Ning Chen, Si-Ming Song, Cui-Cui Zhao, Ya Ruan, Jia-Feng Sha, Qian Liu, Xu-Qin Jiang, Guang-He Fei, Hui-Mei Wu   +9 more
doaj   +1 more source

Evolutionary freedom in the regulation of the conserved itaconate cluster by Ria1 in related Ustilaginaceae

Fungal Biology and Biotechnology, 2018
Background Itaconate is getting growing biotechnological significance, due to its use as a platform compound for the production of bio-based polymers, chemicals, and novel fuels. Currently, Aspergillus terreus is used for its industrial production.
Elena Geiser, Hamed Hosseinpour Tehrani, Svenja Meyer, Lars M. Blank, Nick Wierckx   +4 more
doaj   +1 more source

Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

eLife, 2020
Particulate matter (PM) air pollution causes cardiopulmonary mortality via macrophage-driven lung inflammation; however, the mechanisms are incompletely understood.
Kaitlyn A Sun, Yan Li, Angelo Y Meliton, Parker S Woods, Lucas M Kimmig, Rengül Cetin-Atalay, Robert B Hamanaka, Gökhan M Mutlu   +7 more
doaj   +1 more source

Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8+ T-cell exhaustion

Nature Communications, 2023
Itaconate is a well-known immunomodulatory metabolite; however, its role in hepatocellular carcinoma (HCC) remains unclear. Here, we find that macrophage-derived itaconate promotes HCC by epigenetic induction of Eomesodermin (EOMES)-mediated CD8+ T-cell ...
Xuemei Gu, Haoran Wei, Caixia Suo, Shengqi Shen, Chuxu Zhu, Liang Chen, Kai Yan, Zhikun Li, Zhenhua Bian, Pinggen Zhang, Mengqiu Yuan, Yingxuan Yu, Jinzhi Du, Huafeng Zhang, Linchong Sun, Ping Gao   +15 more
doaj   +1 more source

Inhibition of the Mitochondrial Carnitine/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications

Biomolecules, 2023
Background: The carnitine/acylcarnitine carrier (CAC) represents the route of delivering acyl moieties to the mitochondrial matrix for accomplishing the fatty acid β-oxidation. The CAC has a couple of Cys residues (C136 and C155) most reactive toward ROS
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mariafrancesca Scalise, Cesare Indiveri   +4 more
doaj   +1 more source

Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase

Metabolites, 2021
Itaconate is a small molecule metabolite that is endogenously produced by cis-aconitate decarboxylase-1 (ACOD1) in mammalian cells and influences numerous cellular processes.
Thekla Cordes, Christian M. Metallo
doaj   +1 more source

Itaconate: A Potent Macrophage Immunomodulator

Inflammation, 2023
With advances in immunometabolic studies, more and more evidence has shown that metabolic changes profoundly affect the immune function of macrophages. The tricarboxylic acid cycle is a central metabolic pathway of cells. Itaconate, a byproduct of the tricarboxylic acid cycle, is an emerging metabolic small molecule that regulates macrophage ...
Li, Zeyu, Zheng, Wenbin, Kong, Wen, Zeng, Tianshu   +3 more
openaire   +2 more sources