Results 21 to 30 of about 6,203 (152)

Control of immune cell signaling by the immuno-metabolite itaconate [PDF]

Frontiers in Immunology
Immune cell activation triggers signaling cascades leading to transcriptional reprogramming, but also strongly impacts on the cell’s metabolic activity to provide energy and biomolecules for inflammatory and proliferative responses. Macrophages activated
Roland Lang, Roland Lang, Md Nur A Alam Siddique   +2 more
doaj   +2 more sources

4-Octyl Itaconate Attenuates Age-Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway. [PDF]

FASEB J
4‐Octyl itaconate (4‐OI) attenuates age‐induced parotid gland dysfunction through the suppression of fibrosis and lipid deposition by AMPKα/PPARα and the inhibition of oxidative stress via the AMPKα/Nrf2 signaling pathway. 4‐OI activates AMPKα, which in turn stimulates both the PPARα and Nrf2 pathways. Activation of PPARα enhances FAO and reduces lipid
Chen Y, Gong T, Shan Z, Lai J, Xu Y, Zhao H, Zhu L.   +6 more
europepmc   +2 more sources

Itaconate and Its Derivatives Repress Early Myogenesis In Vitro and In Vivo

Frontiers in Immunology, 2022
A Krebs cycle intermediate metabolite, itaconate, has gained attention as a potential antimicrobial and autoimmune disease treatment due to its anti-inflammatory effects.
Tae Seok Oh, Damian C. Hutchins, Rabina Mainali, Kevin H. Goslen, Matthew A. Quinn, Matthew A. Quinn   +5 more
doaj   +1 more source

Discovery of Itaconate-Mediated Lysine Acylation

, 2023
Itaconate is an important antimicrobial and immunoregulatory metabolite involved in host–pathogen interactions. A key mechanistic action of itaconate is through the covalent modification of cysteine residues via Michael addition, resulting in ...
Suwei Dong, Dongyang Liu (2891114), Shouli Yuan (11562532), Weidi Xiao, Chengxi Li, Haoting Li, Weidi Xiao (1403551), Yanling Zhang (6561), Chu Wang (62506), Chengxi Li (2966559), Suwei Dong (2017039), Dongyang Liu, Yanling Zhang, Chu Wang, Shouli Yuan, Haoting Li (11668435)   +15 more
core   +3 more sources

Itaconate: an antimicrobial metabolite of macrophages [PDF]

, 2021
Itaconate is a conjugated 1,4-dicarboxylate produced by macrophages. This small molecule has recently received increasing attention due to its role in modulating the immune response of macrophages upon exposure to pathogens.
Duncan, Dustin, Auclair, Karine
core   +1 more source

Itaconate attenuates autoimmune hepatitis via PI3K/AKT/mTOR pathway-mediated inhibition of dendritic cell maturation and autophagy

Heliyon, 2023
Autoimmune hepatitis (AIH) results from an autoimmune-mediated chronic inflammatory response against liver cells. Defective self-tolerance and dysfunctional dendritic cells (DCs) play a regulatory role in AIH.
Qiyu Zhang, Yang Luo, Qiuxia Zheng, Haixia Zhao, Xiaofeng Wei, Xun Li   +5 more
doaj   +1 more source

IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury

Frontiers in Immunology, 2022
Inflammation plays an important role in the occurrence and development of neuropathic pain. Immune-responsive gene 1 (IRG1) decarboxylates cis-aconitate to produce itaconate in the mitochondria.
Qingyu Sun, Qingyu Sun, Tingting Hu, Yurui Zhang, Xiaotong Wang, Jing Liu, Wen Chen, Chao Wei, Dianxin Liu, Weihua Wu, Ting Lan, Yumeng Ding, Zhaoli Luo, Meng Liu, Danmin Shen, Zhongnan Xiao, Liye Hu, Miaoyi Pang, Yiran Ma, Lei Shi, Peipei Wang, Jiannan Zhang, Qian Li, Qian Li, Qian Li, Fei Yang, Fei Yang   +26 more
doaj   +1 more source

Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate

Metabolites, 2021
Itaconate is derived from the tricarboxylic acid (TCA) cycle intermediate cis-aconitate and links innate immunity and metabolism. Its synthesis is altered in inflammation-related disorders and it therefore has potential as clinical biomarker.
Moritz Winterhoff, Fangfang Chen, Nishika Sahini, Thomas Ebensen, Maike Kuhn, Volkhard Kaever, Heike Bähre, Frank Pessler   +7 more
doaj   +1 more source

Itaconate controls the severity of pulmonary fibrosis [PDF]

, 2020
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease in which airway macrophages (AMs) play a key role. Itaconate has emerged as a mediator of macrophage function, but its role during fibrosis is unknown.
Gray, Robert, Maher, Toby M, Lloyd, Clare M, Ghai, Poonam, Byrne, Adam J, Hewitt, Richard J, Halket, John M, Molyneaux, Philip L, Calamita, Emily, Chambers, Daniel C, Albers, Gesa J, O'Sullivan, Brendan J, McErlean, Peter, Saunders, Peter, Kingston, Shaun, Ogger, Patricia P, Powell, Joseph E, Walker, Simone A   +17 more
core   +1 more source

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

Cell Reports Medicine, 2021
Summary: The eye is highly susceptible to inflammation-mediated tissue damage evoked during bacterial infection. However, mechanisms regulating inflammation to protect the eye remain elusive.
Sukhvinder Singh, Pawan Kumar Singh, Alokkumar Jha, Poonam Naik, Joveeta Joseph, Shailendra Giri, Ashok Kumar   +6 more
doaj   +1 more source