Results 31 to 40 of about 6,203 (152)

Itaconate-Based Clickable Surface-Anchored Cross-Linked Polymeric Coatings

, 2023
Reactive coatings are those that permit installation of desired segments in a postcoating step; several approaches have been developed to design polymers that can covalently anchor to the substrate while at the same time providing a handle for further ...
Vidyalakshmi Damodara (17029633), Vidyalakshmi Damodara, S. Ramakrishnan, S. Ramakrishnan (1588267)   +3 more
core   +1 more source

Itaconate Isomers in Bread

, 2022
The naturally occurring isomers itaconate, mesaconate and citraconate possess immunomodulatory, antioxidative and antimicrobial properties. However, it is not known whether they occur in commonly consumed human foods. Considering that they can arise as a
Pessler, Frank, Mona Gruenwald, Chen, Fangfang, Fangfang Chen, Gruenwald, Mona, Heike Bähre, Frank Pessler, Bähre, Heike   +7 more
core   +1 more source

Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages. [PDF]

, 2022
peer reviewedSince its discovery in inflammatory macrophages, itaconate has attracted much attention due to its antimicrobial and immunomodulatory activity1-3.
BRENNER, Dirk, Medina, Eva, Garritsen, Hendrikus, Holm, Christian K., Geffers, Robert, Dostert, Catherine, Nikolka, Fabian, Metallo, Christian M., Abdullah, Zeinab, Goldmann, Oliver, He, Wei, Metallo, Christian M, Heinz, Alexander, Grusdat, Melanie, Blay-Cadanet, Julia, Verschueren, Charlène, Henne, Antonia, Kneiling, Manfred, Cordes, Thekla, Holm, Christian K, Geißmar, Eike, Ewen, Anouk, Hiller, Karsten, Härm, Janika, Lauterbach, Mario, Kho, Celia, Latz, Eicke   +26 more
core   +4 more sources

Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8+ T-cell exhaustion

Nature Communications, 2023
Itaconate is a well-known immunomodulatory metabolite; however, its role in hepatocellular carcinoma (HCC) remains unclear. Here, we find that macrophage-derived itaconate promotes HCC by epigenetic induction of Eomesodermin (EOMES)-mediated CD8+ T-cell ...
Xuemei Gu, Haoran Wei, Caixia Suo, Shengqi Shen, Chuxu Zhu, Liang Chen, Kai Yan, Zhikun Li, Zhenhua Bian, Pinggen Zhang, Mengqiu Yuan, Yingxuan Yu, Jinzhi Du, Huafeng Zhang, Linchong Sun, Ping Gao   +15 more
doaj   +1 more source

Inhibition of the Mitochondrial Carnitine/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications

Biomolecules, 2023
Background: The carnitine/acylcarnitine carrier (CAC) represents the route of delivering acyl moieties to the mitochondrial matrix for accomplishing the fatty acid β-oxidation. The CAC has a couple of Cys residues (C136 and C155) most reactive toward ROS
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mariafrancesca Scalise, Cesare Indiveri   +4 more
doaj   +1 more source

Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis

, 2020
Background: Inflammatory stimuli induce immunoresponsive gene 1 (IRG1) expression that in turn catalyzes the production of itaconate from the tricarboxylic acid cycle.
Brown, Dennis A., Ping-Chang Kuo, Yen, Jui-Hung, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, Wang, Pei-Yu, Jui-Hung Yen, Paraiso, Hallel C., Yu, I-Chen, Kuo, Ping-Chang, Scofield, Barbara A., Dennis A. Brown, I-Chen Yu, Pei-Yu Wang, Weng, Wen-Tsan   +15 more
core   +1 more source

Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase

Metabolites, 2021
Itaconate is a small molecule metabolite that is endogenously produced by cis-aconitate decarboxylase-1 (ACOD1) in mammalian cells and influences numerous cellular processes.
Thekla Cordes, Christian M. Metallo
doaj   +1 more source

Depolymerization kinetics of di(4-tert-butyl cyclohexyl) itaconate and Mark-Houwink-Kuhn-Sakurada parameters of di(4-tert- butyl cyclohexyl) itaconate and di-n-butyl itaconate

, 2007
Multipulse pulsed laser polymerization coupled with size exclusion chromatography (MP-PLP-SEC) has been employed to study the depropagation kinetics of the sterically demanding 1,1-disubstituted monomer di(4-tert-butylcyclohexyl) itaconate (DBCHI).
Adler, M., Davis, T. P., Ming Huaming,, Christopher Barner‐Kowollik, Szablan, Z., Huaming, M., Martina H. Stenzel, Stenzel, Martina H., Barner-Kowollik, C., Szablan, Zachary, Davis, Thomas P., Ming Huaming, Adler, Martina, Martina Adler, Stenzel, M. H., Zachary Szablan, Barner-Kowollik, Christopher, Thomas P. Davis   +17 more
core   +1 more source

Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

Nature Communications
Itaconate accumulates in macrophages upon bacterial infection, and manifests antibacterial activity. Convincing evidence substantiates that itaconate is transported across the plasma membrane and vacuolar membrane, but the molecular bases underlying ...
Qingcai Meng, Chengxi Li, Yuping Cai, Ying Chen, Xiaoqing Chen, Xin Wang, Biling Zhang, Yue Zhang, Feng Liu, Meixin Chen   +9 more
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source