Results 31 to 40 of about 4,169 (171)

Chemoproteomic profiling of itaconations in Salmonella

Chemical Science, 2021
Bioorthogonal probes have been developed to enable quantitative and site-specific profiling of itaconate modifications in Salmonella.
Yanling Zhang, Wei Qin, Dongyang Liu, Yuan Liu, Chu Wang   +4 more
openaire   +3 more sources

Itaconate as an immune modulator

Aging, 2019
Contains fulltext : 206784.pdf (Publisher’s version ) (Open Access)
Ferreira, A.V., Netea, M.G., Netea, M.G., Dominguez Andres, J.   +3 more
openaire   +4 more sources

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury

Molecular Metabolism, 2020
Objectives: Cerebral ischemia/reperfusion (IR) drives oxidative stress and injurious metabolic processes that lead to redox imbalance, inflammation, and tissue damage.
Thekla Cordes, Alfredo Lucas, Ajit S. Divakaruni, Anne N. Murphy, Pedro Cabrales, Christian M. Metallo   +5 more
doaj   +1 more source

Metabolite itaconate in host immunoregulation and defense

Cellular & Molecular Biology Letters, 2023
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune cells can effectively modulate the host immune response.
Wenchang Yang, Yaxin Wang, Kaixiong Tao, Ruidong Li   +3 more
doaj   +1 more source

Itaconate biosynthesis in Aspergillus terreus [PDF]

Journal of Bacteriology, 1995
Itaconate biosynthesis was studied in intact cells of high-yield (RC4') and low-yield (CM85J) strains of the fungus Aspergillus terreus by methods (tracers, nuclear magnetic resonance spectroscopy, and mass spectroscopy) that did not interfere with metabolism. Itaconate formation in RC4' required de novo protein biosynthesis.
P, Bonnarme, B, Gillet, A M, Sepulchre, C, Role, J C, Beloeil, C, Ducrocq   +5 more
openaire   +2 more sources

Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus [PDF]

Applied Microbiology and Biotechnology, 2016
Itaconic acid, one of the most promising and flexible bio-based chemicals, is mainly produced by Aspergillus terreus. Previous studies to improve itaconic acid production in A. terreus through metabolic engineering were mainly focused on its biosynthesis pathway, while the itaconic acid-degrading pathway has largely been ignored. In this study, we used
Mei, Chen, Xuenian, Huang, Chengwei, Zhong, Jianjun, Li, Xuefeng, Lu   +4 more
openaire   +2 more sources

From Olefin Coordination to Rh─N Bond Formation and Oxidative Addition: pH Effects in Rhodium α‐Methyl‐β‐Amidoitaconate Complexes

European Journal of Inorganic Chemistry, EarlyView.
The coordination of α‐methyl‐β‐amidoitaconate at Rh(I) diphosphine complexes is studied using a combination of high‐field and low‐field flow NMR spectroscopy and X‐ray analysis. In the presence of basic or acidic additives, the formation of neutral Rh(I) or Rh(III) complexes occurs.
Neeraja M. Kaimal, Thomas Osterland, Hans‐Joachim Drexler, Torsten Beweries   +3 more
wiley   +1 more source

A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages

Nature Communications, 2022
Itaconate has been identified as an immunomodulatory metabolite produced by activated macrophages, but methods for detecting itaconate in live cells are lacking.
Pengkai Sun, Zhenxing Zhang, Bin Wang, Caiyun Liu, Chao Chen, Ping Liu, Xinjian Li   +6 more
doaj   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2

EBioMedicine, 2020
Absract: Background: Identifying effective drugs to suppress vascular inflammation is a promising strategy to delay the progression of abdominal aortic aneurysm (AAA).
Haoyu Song, Tong Xu, Xiaofei Feng, Yanxian Lai, Yang Yang, Hao Zheng, Xiang He, Guoquan Wei, Wangjun Liao, Yulin Liao, Lintao Zhong, Jianping Bin   +11 more
doaj   +1 more source