Results 11 to 20 of about 6,203 (152)
Itaconate family-based host-directed therapeutics for infections [PDF]
Frontiers in Immunology, 2023 Itaconate is a crucial anti-infective and anti-inflammatory immunometabolite that accumulates upon disruption of the Krebs cycle in effector macrophages undergoing inflammatory stress.
Jae-Min Yuk +10 more
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Itaconate-mediated inhibition of succinate dehydrogenase regulates cytokine production in LPS-induced inflammation [PDF]
Медицинская иммунология, 2023 Itaconate is an immunoregulatory metabolite produced by myeloid cells and plays a key role in the regulation of the immune response. Itaconate, on the one hand, is able to suppress the activity of succinate dehydrogenase (SDH), thereby making a ...
D. E. Anisov +3 more
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Fungal Biology and Biotechnology, 2018 Background Itaconate is getting growing biotechnological significance, due to its use as a platform compound for the production of bio-based polymers, chemicals, and novel fuels. Currently, Aspergillus terreus is used for its industrial production.
Elena Geiser +4 more
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Antioxidants, 2023 Itaconate has emerged as a novel anti-inflammatory and antioxidative endogenous metabolite, yet its role in allergic airway inflammation (AAI) and the underlying mechanism remains elusive.
Qiu-Meng Xie +9 more
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Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response [PDF]
eLife, 2020 Particulate matter (PM) air pollution causes cardiopulmonary mortality via macrophage-driven lung inflammation; however, the mechanisms are incompletely understood.
Kaitlyn A Sun +7 more
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Divergent effects of itaconate isomers on Coxiella burnetii growth in macrophages and in axenic culture [PDF]
Frontiers in ImmunologyAconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects.
Md Nur A Alam Siddique +8 more
doaj +3 more sources
Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury [PDF]
Molecular Metabolism, 2020 Objectives: Cerebral ischemia/reperfusion (IR) drives oxidative stress and injurious metabolic processes that lead to redox imbalance, inflammation, and tissue damage.
Thekla Cordes +5 more
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Bone ResearchItaconate, a macrophage-specific anti-inflammatory metabolite, has recently emerged as a critical regulator in rheumatoid arthritis pathogenesis. We found that itaconate is a TNF-α responsive metabolite significantly elevated in the serum and synovial ...
Kewei Rong +15 more
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Itaconate-producing neutrophils regulate local and systemic inflammation following trauma [PDF]
JCI Insight, 2023 Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injuries that undergo ...
Janna L. Crossley +12 more
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Itaconate alleviates diet-induced obesity via activation of brown adipocyte thermogenesis
Cell ReportsSummary: Despite medical advances, there remains an unmet need for better treatment of obesity. Itaconate, a product of the decarboxylation of the tricarboxylic acid cycle intermediate cis-aconitate, plays a regulatory role in both metabolism and ...
Zihan Yu +12 more
doaj +2 more sources