Results 11 to 20 of about 4,169 (171)

Itaconate modifications: Mechanisms and applications [PDF]

Journal of Intensive Medicine
Itaconate is a mitochondrial metabolite generated from the tricarboxylic acid cycle intermediate cis-aconitate by the enzyme aconitate decarboxylase 1 (ACOD1).
Yingyi Yang, Rui Kang, Huiting Zhou, Daolin Tang   +3 more
doaj   +2 more sources

Protective role of IRG1/itaconate in acute myocardial injury: association with NLRP3 inflammasome and oxidative stress [PDF]

Scientific Reports
Increasing evidence indicates the critical role of Immune response gene 1 (IRG1)-derived itaconate in metabolic regulation and signal transduction, with therapeutic implications for inflammatory diseases.
Hui Chen, Kerui Fan, Shu Xiang, Nian Zeng, Hui Wen, Jun Cai, Kun Chen, Xiaojiao He   +7 more
doaj   +2 more sources

Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense [PDF]

JCI Insight
Mycobacterium tuberculosis (Mtb) survives within multiple macrophage populations during infection, including alveolar macrophages (AMs) and recruited inflammatory macrophages.
Adam S. Krebs, Tomi Lazarov, Anthony T. Reynolds, Kimberly A. Dill-McFarland, Abigail Xie, James M. Bean, Muxue Du, Olivier Levy, John A. Buglino, Aaron Zhong, Anna-Lena Neehus, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova, Elouise E. Kroon, Marlo Möller, Thomas R. Hawn, Ting Zhou, Lydia W.S. Finley, Marc Antoine Jean Juste, Dan W. Fitzgerald, Frederic Geissmann, Michael S. Glickman   +21 more
doaj   +2 more sources

Stromal cell-derived itaconate promotes endometriosis via macrophage NRF2 and lysosomal pH modulation [PDF]

Redox Biology
Endometriosis (EM) is driven by immune dysregulation and macrophage dysfunction, yet the underlying mechanisms remain unclear. Here, metabolomic profiling revealed excessive itaconate accumulation in EM lesions, primarily due to elevated cis-aconitate ...
Zhaoyang Zhong, Shuang Wang, Qianhui Ren, Xue Jiao, Le Xu, Xiaoyu Dong, Na Li, Hongwei Guan, Ran Chu, Ming Yuan, Jincheng Liu, Yanbo Du, Keke Wei, Lei Yan, Guoyun Wang   +14 more
doaj   +2 more sources

Dimethyl itaconate suppresses dendritic cell and CD8+ T cell responses to halt vitiligo [PDF]

BMC Medicine
Background Although dendritic cell (DC)- and CD8+ T cell-mediated autoimmunity is critical for destroying melanocytes in vitiligo, treatment options remain limited by the absence of therapies that cotarget both cell types.
Yinghan Wang, Yuhan Chen, Jingjing Ma, Linxuan Wu, Pan Kang, Jianru Chen, Pengran Du, Wei Wu, Xinju Wang, Kaiqiao He, Yuqi Yang, Sen Guo, Weinan Guo, Ling Liu, Zhe Jian, Tianwen Gao, Shuli Li, Chunying Li   +17 more
doaj   +2 more sources

Itaconate family-based host-directed therapeutics for infections

Frontiers in Immunology, 2023
Itaconate is a crucial anti-infective and anti-inflammatory immunometabolite that accumulates upon disruption of the Krebs cycle in effector macrophages undergoing inflammatory stress.
Jae-Min Yuk, Jae-Min Yuk, Jae-Min Yuk, Eun-Jin Park, Eun-Jin Park, In Soo Kim, In Soo Kim, In Soo Kim, Eun-Kyeong Jo, Eun-Kyeong Jo, Eun-Kyeong Jo   +10 more
doaj   +1 more source

Itaconate and Its Derivatives Repress Early Myogenesis In Vitro and In Vivo

Frontiers in Immunology, 2022
A Krebs cycle intermediate metabolite, itaconate, has gained attention as a potential antimicrobial and autoimmune disease treatment due to its anti-inflammatory effects.
Tae Seok Oh, Damian C. Hutchins, Rabina Mainali, Kevin H. Goslen, Matthew A. Quinn, Matthew A. Quinn   +5 more
doaj   +1 more source

Itaconate-mediated inhibition of succinate dehydrogenase regulates cytokine production in LPS-induced inflammation

Медицинская иммунология, 2023
Itaconate is an immunoregulatory metabolite produced by myeloid cells and plays a key role in the regulation of the immune response. Itaconate, on the one hand, is able to suppress the activity of succinate dehydrogenase (SDH), thereby making a ...
D. E. Anisov, M. S. Drutskaya, M. A. Nosenko, S. A. Nedospasov   +3 more
doaj   +1 more source

IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury

Frontiers in Immunology, 2022
Inflammation plays an important role in the occurrence and development of neuropathic pain. Immune-responsive gene 1 (IRG1) decarboxylates cis-aconitate to produce itaconate in the mitochondria.
Qingyu Sun, Qingyu Sun, Tingting Hu, Yurui Zhang, Xiaotong Wang, Jing Liu, Wen Chen, Chao Wei, Dianxin Liu, Weihua Wu, Ting Lan, Yumeng Ding, Zhaoli Luo, Meng Liu, Danmin Shen, Zhongnan Xiao, Liye Hu, Miaoyi Pang, Yiran Ma, Lei Shi, Peipei Wang, Jiannan Zhang, Qian Li, Qian Li, Qian Li, Fei Yang, Fei Yang   +26 more
doaj   +1 more source

Itaconate attenuates autoimmune hepatitis via PI3K/AKT/mTOR pathway-mediated inhibition of dendritic cell maturation and autophagy

Heliyon, 2023
Autoimmune hepatitis (AIH) results from an autoimmune-mediated chronic inflammatory response against liver cells. Defective self-tolerance and dysfunctional dendritic cells (DCs) play a regulatory role in AIH.
Qiyu Zhang, Yang Luo, Qiuxia Zheng, Haixia Zhao, Xiaofeng Wei, Xun Li   +5 more
doaj   +1 more source