ACOD1 regulates microglial arginine metabolism and inflammatory responses [PDF]
Frontiers in ImmunologyItaconate is produced by inflammatory macrophages and promotes negative feedback on inflammation. It is synthesized by aconitate decarboxylase 1 (ACOD1) from cis-aconitate, a metabolite of the tricarboxylic acid cycle.
Eleftheria Karadima +12 more
doaj +2 more sources
Scientific Reports, 2023 cis-Aconitate decarboxylase (ACOD1, IRG1) converts cis-aconitate to the immunomodulatory and antibacterial metabolite itaconate. Although the active site residues of human and mouse ACOD1 are identical, the mouse enzyme is about fivefold more active ...
Fangfang Chen +2 more
exaly +2 more sources
The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
IScience, 2022 Summary: ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in ...
Daolin Tang, Runliu Wu, Rui Kang
exaly +3 more sources
scH16S-Seq Maps Klebsiella pneumoniae-Associated Myeloid States and Reveals a CD38-NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis. [PDF]
Adv Sci (Weinh)Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Li Y +15 more
europepmc +2 more sources
ACOD1 deficiency promotes DDX1 methylation–mediated mitochondrial dysfunction and dermal papilla cell senescence in androgenetic alopecia [PDF]
BMC MedicineBackground Androgenetic alopecia (AGA), the most prevalent form of hair loss, is driven by the dysfunction of dermal papilla cells (DPCs). Emerging evidence implicates DPC senescence in the pathogenesis of AGA; however, the underlying molecular ...
Min Zhao +10 more
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ACOD1 expression in patients with sepsis: an exploratory study of associations with disease severity and immune signatures [PDF]
BMC Infectious DiseasesSepsis is a life-threatening condition caused by a dysregulated host response to infection, and its pathogenesis is closely linked to immune dysregulation and inflammation. Aconitate decarboxylase 1 (ACOD1) and its metabolite itaconate are key regulators
Huiwen Xiong +5 more
doaj +2 more sources
Nature Communications, 2023 The pro-inflammatory state of macrophages, underpinned by their metabolic condition, is essentially affecting their capacity of combating tumor cells.
Hua Yu, Xiaolong Cheng
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Itaconate negatively regulates innate immunity during fungal pneumonia [PDF]
mBioThe innate immune response to pathogens often involves metabolic reprogramming, such as disruption of the Krebs cycle, leading to the accumulation of various metabolites that can further influence innate cell responses during infection.
Thomas Draper +5 more
doaj +2 more sources
ACOD1-itaconate in macrophage attenuates oxidative stress and inflammation in benign airway stenosis by upregulating and transferring FTH1 [PDF]
Redox BiologyThe oxidative stress of macrophage plays pivotal roles of acute and chronic inflammation and chronic fibrotic phases, in which the metabolic mechanism needs to be further explored.
YiLin Chen +15 more
doaj +2 more sources
Acod1/itaconate axis controls anxiety-like behaviors induced by chronic infection of Toxoplasma gondii in mice. [PDF]
PLoS Neglected Tropical DiseasesBackgroundChronic infection of Toxoplasma gondii (T. gondii) induces the anxiety-like behavior in hosts, which is closely linked to neuroinflammatory processes. Cis-aconite decarboxylase 1 (Acod1) is an enzyme that is responsible for itaconate production
Ziyi Yan +12 more
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