Results 41 to 50 of about 1,632 (144)
Frontiers in Immunology, 2022 BackgroundNeurodegenerative diseases including AD is currently one of intractable problems globally due to the insufficiency of intervention strategies. Long-term infection of Toxoplasma gondii (T.
Yan He +24 more
doaj +1 more source
Acod1 is important in the regulation of Lyme carditis in vivo.
, 2023 A) Two weeks post infection hearts from NJ WT and Acod1-/- mice were sectioned and stained with H&E and scored blindly by a pathology for inflammation using a scale of 0–10. Nine mice from two independent experiments were analyzed with Mann-Whitney Test.
Linden T. Hu (13989808) +5 more
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Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1 [PDF]
, 2023 Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance immunotherapy, yet it remains a challenge to identify therapeutic ...
Xiaoyang Su +59 more
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Shiyan dongwu yu bijiao yixue, 2023 ObjectiveUsing transcriptome sequencing to screen the differentially expressed genes between the synovial tissue of rats with knee osteoarthritis (KOA) induced by monosodium iodoacetate (MIA) and that of normal rats, and then screen the target of ...
YANG Ling, ZHUANG Di, JIN Lilun
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Advanced Science, EarlyView.This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang +5 more
wiley +1 more source
Acod1 gene expression is correlated to Brucella control in the lungs.
, 2021 (A) Wild-type and Acod1-/- C57BL/6 mice were intranasally infected with 107 CFU of wild-type B. melitensis 16M or B. abortus 2308, as indicated. At 2-, 5-, 9- and 28-days post-infection, lungs and spleen were harvested and CFU were counted.
Mégane Van Gysel (11436992) +16 more
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Arthritis &Rheumatology, EarlyView.Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt +18 more
wiley +1 more source
Modulation of the Acod1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes. [PDF]
peer reviewedItaconate is a macrophage-derived metabolite central to immunometabolism (1, 2). Its role, including 4-octyl-itaconate (4-OI), has sparked interest in atherosclerosis because of its known inflammatory characteristics. Song et al.
Arefeh Khakdan +35 more
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Acod1 is dispensable for Bone marrow derived macrophages control of Brucella infection.
, 2021 Bone marrow derived macrophages from wild type and Acod1-/- C57BL/6 mice were infected with B. melitensis or B. abortus at an MOI of 50:1, as indicated in Materials and Methods.
Mégane Van Gysel (11436992) +16 more
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Differences among human myeloid cells in ACOD1 mRNA induction during IAV infection.
, 2022 Cells were infected with the indicated IAV strains (MOI = 1) and gene expression determined at the time points post infection (p.i.) indicated on the x-axes. A.
Mahmoud Shehata (9574695) +20 more
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