Results 61 to 70 of about 1,632 (144)
Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures
Frontiers in ImmunologyBackgroundEnvironmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations ...
Aaron D. Schwab +16 more
doaj +1 more source
Physiological Reports, Volume 14, Issue 19, October 2026.ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura +3 more
wiley +1 more source
, 2021 Wild-type and Acod1-/- C57BL/6 mice were intraperitoneally infected with 107 CFU of wild-type B. abortus 2308, as indicated. At 2-, 5- and 9-days post-infection, spleen were harvested and CFU were counted. Each point represents one mouse, n = 8. Grey bar
Mégane Van Gysel (11436992) +16 more
core +1 more source
Die Rolle von ACOD1 in der Pathogenese der Glomerulonephritis [PDF]
Die Regulation metabolischer Prozesse ist ein wesentlicher Bestandteil der Aktivierung von Immunzellen. Die Erforschung der Rolle des Metabolismus für die Entstehung von entzündlichen Erkrankungen erhält zunehmende Aufmerksamkeit in der Immunologie.
Trinsch, Bastian
core +1 more source
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang +4 more
wiley +1 more source
Effects of itaconates on phosphorylation of STAT1 and AKT, ACOD1 mRNA expression, and ROS levels.
, 2022 Treatments (itaconate, 20 mM; DI 0.5 mM; 4OI 125 μM) were applied as indicated to dTHP1 cells infected with IAV (PR8M, MOI = 1), and analyses performed 12 h p.i. A.
Mahmoud Shehata (9574695) +20 more
core +1 more source
Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang +10 more
wiley +1 more source
Effect of overexpression of ACOD1 and exogenous treatment with DI on IAV-infected A549 cells.
, 2022 A. A549 cells were transfected with pCMV6-Hu-ACOD1, pCMV6 empty vector, or mock transfected for 48 h and then infected with IAV (PR8M, MOI = 1) for 48 h (n = 3). Expression of the indicated mRNAs was measured by RT-qPCR, itaconate concentrations by LC-MS/
Mahmoud Shehata (9574695) +20 more
core +1 more source
MedComm – Oncology, Volume 5, Issue 3, September 2026.Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K +5 more
wiley +1 more source